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Impurities and reference standards

Digoxigenin

Also known as Lanadigenin, Digoxigenine, Card-20(22)-enolide, 3,12,14-trihydroxy-, (3beta,5beta,12beta)-

CAS 1672-46-4Formula C23H34O5Molar mass 390.52 g/molEC 216-806-2
GHS signal word: Danger. Pictograms: Acute toxicity (severe) 60 suppliers listed
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Digoxigenin chemical structure, C23H34O5, CAS 1672-46-4
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Prisms from ethyl acetate
Melting point
222 °C
Solubility
Very soluble in ethanol and methanol, slightly soluble in chloroform
HS code
293220
Category
Impurities and reference standards
Illustrative photo, closed white HDPE bottles and amber jars on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Digoxigenin?

Plain description, key identifiers and synonyms

Digoxigenin is a hydroxy steroid that consists of 5beta-cardanolide having a double bond at the 20(22)-position as well as hydroxy groups at the 3beta-, 12beta- and 14beta-positions. It has been isolated from the plant species of the genus Digitalis. It has a role as a hapten and a plant metabolite. It is a 3beta-sterol, a 3beta-hydroxy steroid, a 12beta-hydroxy steroid and a 14beta-hydroxy steroid. It is a conjugate acid of a digoxigenin(1-). It derives from a hydride of a 5beta-cardanolide.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
3-[(3S,5R,8R,9S,10S,12R,13S,14S,17R)-3,12,14-trihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2H-furan-5-one
CAS number
1672-46-4 CAS number cross-checked
EC number
216-806-2
Molecular formula
C23H34O5
UNII
NQ1SX9LNAU
InChIKey
SHIBSTMRCDJXLN-KCZCNTNESA-N
InChI
InChI=1S/C23H34O5/c1-21-7-5-15(24)10-14(21)3-4-17-18(21)11-19(25)22(2)16(6-8-23(17,22)27)13-9-20(26)28-12-13/h9,14-19,24-25,27H,3-8,10-12H2,1-2H3/t14-,15+,16-,17-,18+,19-,21+,22+,23+/m1/s1
Canonical SMILES
CC12CCC(O)CC1CCC1C2CC(O)C2(C)C(C3=CC(=O)OC3)CCC12O
Isomeric SMILES
C[C@]12CC[C@@H](C[C@H]1CC[C@@H]3[C@@H]2C[C@H]([C@]4([C@@]3(CC[C@@H]4C5=CC(=O)OC5)O)C)O)O

Synonyms

  • Lanadigenin
  • Digoxigenine
  • Card-20(22)-enolide, 3,12,14-trihydroxy-, (3beta,5beta,12beta)-
  • 3beta,12beta,14-trihydroxy-5beta-card-20(22)-enolide
  • delta-sup(20:22)-3-beta,12-beta,14,21-Tetrahydroxynorcholenic acid lactone
  • Lanadigigenin
  • 4-((3S,5R,8R,9S,10S,12R,13S,14S,17R)-3,12,14-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)furan-2(5H)-one
  • 3beta,12beta,14-Trihydroxy-5beta,20(22)-cardenolide
  • Card-20(22)-enolide, 3,12,14-trihydroxy-, (3ss,5ss,12ss)-
  • Digoxin EP Impurity C
  • Digoxigenin CRS
  • 1lke
  • ST 23:3, O5
  • 4-[(3S,5R,8R,9S,10S,12R,13S,14S,17R)-3,12,14-Trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl]furan-2(5H)-one
  • 3-beta,12-beta,14-Trihydroxy-card-20(22)-enolide
  • 3-beta,12,14-Trioxy-digen-(20:22)-olid
  • 3-beta,12,14-Trioxy-carden-(20:22)-olid
  • Cardogenen-(20:22)-triol-(3-beta,12,14)
  • 4j8t
  • 4j9a
  • (3beta,5beta,12beta)-3,12,14-Trihydroxycard-20(22)-enolide
  • 5-18-04-00380 (Beilstein Handbook Reference)
  • Digoxigenin, analytical standard
  • Digoxin EP Impurity C, Digoxigenin
  • 3beta,12beta,14beta,21-Tetrahydroxy-20(22)-norcholenic acid lactone
Show all 27 synonyms
  • 5-beta-CARD-20(22)-ENOLIDE, 3-beta,12-beta,14-TRIHYDROXY-
  • Card-20(22)-enolide, 3,12,14-trihydroxy-, (3|A,5|A,12|A)-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Prisms from ethyl acetateexp.
Melting point
222 °Cexp.
Solubility
Very soluble in ethanol and methanol, slightly soluble in chloroformexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
390.52 g/molcalc.
Exact mass
390.2406 Dacalc.
LogP (octanol/water)
2.58calc.
Topological polar surface area
86.99 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
1calc.
Heavy atoms
28calc.
Rings
5calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.87calc.
Formal charge
0calc.
Stereocentres
9calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1C=C(C2CCC3C2CCC2C4CCCCC4CCC23)CO1

O=C1C=C(C2CCC3C2CCC2C4CCCCC4CCC23)CO1

5 rings, 23 atoms.

126 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)

Hazard statements

  • H300Fatal if swallowed.
  • H310Fatal in contact with skin.
  • H330Fatal if inhaled.
Precautionary statements (18)
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P262Do not get in eyes, on skin, or on clothing.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P284In case of inadequate ventilation wear respiratory protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P316Get emergency medical help immediately.
  • P320Specific treatment is urgent (see supplemental first aid instructions on the label).
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P361 + P364Take off immediately all contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Digoxigenin suppliers

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Where suppliers are based

60 suppliers in 13 countries

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Digoxigenin price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Laboratory chemicals, manufacture of substances.

Roles

  • eukaryotic metabolite
  • hapten
  • metabolite
  • plant metabolite

How it is made

By hydrolysis of digoxin...

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Digoxigenin is traded under.

HS 2932.20Indicative HS code

Lactones

World exports in 2024
$1.97B
−4.7% vs 2023, imports $2.07B
2019 to 2024
Top exporters
  1. China56.3%
  2. India * partner reported7.4%
  3. Germany7.3%
Top importers
  1. United States14.2%
  2. India * partner reported13.5%
  3. Brazil8.5%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Digoxigenin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Digoxigenin, based on the data on this page

What is Digoxigenin?

Digoxigenin is a hydroxy steroid that consists of 5beta-cardanolide having a double bond at the 20(22)-position as well as hydroxy groups at the 3beta-, 12beta- and 14beta-positions. It has been isolated from the plant species of the genus Digitalis. It has a role as a hapten and a plant metabolite.

What is the CAS number of Digoxigenin?

The CAS registry number of Digoxigenin is 1672-46-4.

What is the molecular formula and weight of Digoxigenin?

The molecular formula of Digoxigenin is C23H34O5 and its molar mass is 390.52 g/mol.

What is Digoxigenin used for?

Laboratory chemicals, manufacture of substances.

Is Digoxigenin hazardous?

Digoxigenin carries the GHS signal word "Danger". Main hazards: fatal if swallowed, fatal in contact with skin, fatal if inhaled. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Digoxigenin?

Digoxigenin is usually classified under HS code 293220 (Lactones). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Digoxigenin?

CompoundList lists 60 suppliers of Digoxigenin in United States, China, Germany, Spain and 9 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Digoxigenin?

Suppliers quote Digoxigenin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Digoxigenin

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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