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Murcko scaffold

Ring system with 2 rings and 13 atoms

27 chemicals on CompoundList share this ring system.

Rings: 2
Scaffold atoms: 13
Chemicals: 27
With full pages: 8

Scaffold SMILES

C=C1C=NN(c2ccccc2)C1=O

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold C=C1C=NN(c2ccccc2)C1=O

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 27 of 27 chemicals

4-[(Dimethylamino)methylene]-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one chemical structure, C13H15N3O

4-[(Dimethylamino)methylene]-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one

C₁₃H₁₅N₃O

Benzenesulfonic acid, 4-(4,5-dihydro-3-methyl-4-(1-methylethylidene)-5-oxo-1H-pyrazol-1-yl)-, compd. with piperidine (1:1) chemical structure, C18H25N3O4S, CAS 63123-38-6

Benzenesulfonic acid, 4-(4,5-dihydro-3-methyl-4-(1-methylethylidene)-5-oxo-1H-pyrazol-1-yl)-, compd. with piperidine (1:1)

CAS 63123-38-6C₁₈H₂₅N₃O₄S

4-[(Dimethylamino)methylene]-2-phenyl-5-(trifluoromethyl)-2,4-dihydro-3H-pyrazol-3-one chemical structure, C13H12F3N3O, CAS 69586-72-7

4-[(Dimethylamino)methylene]-2-phenyl-5-(trifluoromethyl)-2,4-dihydro-3H-pyrazol-3-one

CAS 69586-72-7C₁₃H₁₂F₃N₃O

(4E)-4-(Dimethylaminomethylidene)-2-[4-(trifluoromethoxy)phenyl]-5-(trifluoromethyl)pyrazol-3-one chemical structure, C14H11F6N3O2, CAS 338403-22-8

(4E)-4-(Dimethylaminomethylidene)-2-[4-(trifluoromethoxy)phenyl]-5-(trifluoromethyl)pyrazol-3-one

CAS 338403-22-8C₁₄H₁₁F₆N₃O₂

Methyl {(4E)-4-[(dimethylamino)methylene]-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-3-YL}acetate chemical structure, C15H17N3O3, CAS 669753-32-6

Methyl {(4E)-4-[(dimethylamino)methylene]-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-3-YL}acetate

CAS 669753-32-6C₁₅H₁₇N₃O₃

Methyl {(4Z)-4-[(dimethylamino)methylene]-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl}acetate chemical structure, C15H17N3O3, CAS 660441-18-9

Methyl {(4Z)-4-[(dimethylamino)methylene]-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl}acetate

CAS 660441-18-9C₁₅H₁₇N₃O₃

(4E)-4-(Dimethylaminomethylidene)-5-methyl-2-phenylpyrazol-3-one chemical structure, C13H15N3O, CAS 65644-13-5

(4E)-4-(Dimethylaminomethylidene)-5-methyl-2-phenylpyrazol-3-one

CAS 65644-13-5C₁₃H₁₅N₃O

4-[(Dimethylamino)methylene]-5-methyl-2-(4-nitrophenyl)-2,4-dihydro-3H-pyrazol-3-one chemical structure, C13H14N4O3, CAS 1164564-44-6

4-[(Dimethylamino)methylene]-5-methyl-2-(4-nitrophenyl)-2,4-dihydro-3H-pyrazol-3-one

CAS 1164564-44-6C₁₃H₁₄N₄O₃

2-Pyrazolin-5-one, 4-((dimethylamino)methylene)-3-methyl-1-phenyl- chemical structure, C13H15N3O, CAS 4942-70-5

2-Pyrazolin-5-one, 4-((dimethylamino)methylene)-3-methyl-1-phenyl-

CAS 4942-70-5C₁₃H₁₅N₃O

2-Pyrazolin-5-one, 4-dimethylaminomethylene-1-phenyl-3-propyl- chemical structure, C15H19N3O, CAS 15900-09-1

2-Pyrazolin-5-one, 4-dimethylaminomethylene-1-phenyl-3-propyl-

CAS 15900-09-1C₁₅H₁₉N₃O

4-[(Dimethylamino)methylidene]-3-methyl-1-(4-nitrophenyl)-4,5-dihydro-1H-pyrazol-5-one chemical structure, C13H14N4O3

4-[(Dimethylamino)methylidene]-3-methyl-1-(4-nitrophenyl)-4,5-dihydro-1H-pyrazol-5-one

C₁₃H₁₄N₄O₃

Methyl 2-[4-(dimethylaminomethylidene)-5-oxo-1-phenylpyrazol-3-yl]acetate chemical structure, C15H17N3O3

Methyl 2-[4-(dimethylaminomethylidene)-5-oxo-1-phenylpyrazol-3-yl]acetate

C₁₅H₁₇N₃O₃

4-Isopropylidene-5-methyl-2-phenyl-2,4-dihydro-pyrazol-3-one chemical structure, C13H14N2O, CAS 22123-17-7

4-Isopropylidene-5-methyl-2-phenyl-2,4-dihydro-pyrazol-3-one

CAS 22123-17-7C₁₃H₁₄N₂O

4-[(Dimethylamino)methylene]-5-ethoxy-2-phenyl-2,4-dihydro-3H-pyrazol-3-one chemical structure, C14H17N3O2, CAS 338750-89-3

4-[(Dimethylamino)methylene]-5-ethoxy-2-phenyl-2,4-dihydro-3H-pyrazol-3-one

CAS 338750-89-3C₁₄H₁₇N₃O₂

2-(4-Chlorophenyl)-4-[(dimethylamino)methylene]-5-ethoxy-2,4-dihydro-3H-pyrazol-3-one chemical structure, C14H16ClN3O2, CAS 338751-00-1

2-(4-Chlorophenyl)-4-[(dimethylamino)methylene]-5-ethoxy-2,4-dihydro-3H-pyrazol-3-one

CAS 338751-00-1C₁₄H₁₆ClN₃O₂

(Z)-4-((Dimethylamino)methylene)-3-methyl-1-(4-nitrophenyl)-1H-pyrazol-5(4H)-one chemical structure, C13H14N4O3

(Z)-4-((Dimethylamino)methylene)-3-methyl-1-(4-nitrophenyl)-1H-pyrazol-5(4H)-one

C₁₃H₁₄N₄O₃

2-Phenyl-4-(propan-2-ylidene)-2,4-dihydro-3H-pyrazol-3-one chemical structure, C12H12N2O, CAS 49597-19-5

2-Phenyl-4-(propan-2-ylidene)-2,4-dihydro-3H-pyrazol-3-one

CAS 49597-19-5C₁₂H₁₂N₂O

4-(Bis(methylthio)methylene)-2-(4-bromophenyl)-2,4-dihydro-5-methyl-3H-pyrazol-3-one chemical structure, C13H13BrN2OS2, CAS 141213-12-9

4-(Bis(methylthio)methylene)-2-(4-bromophenyl)-2,4-dihydro-5-methyl-3H-pyrazol-3-one

CAS 141213-12-9C₁₃H₁₃BrN₂OS₂

Methyl (2E)-3-(dimethylamino)-2-{(4Z)-4-[(dimethylamino)methylene]-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl}acrylate chemical structure, C18H22N4O3, CAS 1152430-03-9

Methyl (2E)-3-(dimethylamino)-2-{(4Z)-4-[(dimethylamino)methylene]-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl}acrylate

CAS 1152430-03-9C₁₈H₂₂N₄O₃

Methyl [(4Z)-4-[(dimethylamino)methylene]-1-(4-methoxyphenyl)-5-oxo-4,5-dihydro-1H-pyrazol-3-yl]acetate chemical structure, C16H19N3O4, CAS 1379821-56-3

Methyl [(4Z)-4-[(dimethylamino)methylene]-1-(4-methoxyphenyl)-5-oxo-4,5-dihydro-1H-pyrazol-3-yl]acetate

CAS 1379821-56-3C₁₆H₁₉N₃O₄

Methyl (2E)-3-(dimethylamino)-2-[(4Z)-4-[(dimethylamino)methylene]-1-(4-methoxyphenyl)-5-oxo-4,5-dihydro-1H-pyrazol-3-yl]acrylate chemical structure, C19H24N4O4, CAS 1379821-58-5

Methyl (2E)-3-(dimethylamino)-2-[(4Z)-4-[(dimethylamino)methylene]-1-(4-methoxyphenyl)-5-oxo-4,5-dihydro-1H-pyrazol-3-yl]acrylate

CAS 1379821-58-5C₁₉H₂₄N₄O₄

3-tert-Butyl-4-(chloromethylidene)-1-phenyl-4,5-dihydro-1H-pyrazol-5-one chemical structure, C14H15ClN2O, CAS 1423037-11-9

3-tert-Butyl-4-(chloromethylidene)-1-phenyl-4,5-dihydro-1H-pyrazol-5-one

CAS 1423037-11-9C₁₄H₁₅ClN₂O

(4Z)-5-tert-Butyl-4-(chloromethylidene)-2-phenylpyrazol-3-one chemical structure, C14H15ClN2O

(4Z)-5-tert-Butyl-4-(chloromethylidene)-2-phenylpyrazol-3-one

C₁₄H₁₅ClN₂O

5-tert-Butyl-4-(chloromethylidene)-2-phenylpyrazol-3-one chemical structure, C14H15ClN2O

5-tert-Butyl-4-(chloromethylidene)-2-phenylpyrazol-3-one

C₁₄H₁₅ClN₂O