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Murcko scaffold

Ring system with 5 rings and 28 atoms

8 chemicals on CompoundList share this ring system.

Rings
5
Scaffold atoms
28
Chemicals
8
With full pages
4
Scaffold SMILES

C(=Cc1cn(-c2ccccc2)nc1-c1ccccc1)c1nc2ccccc2[nH]1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold C(=Cc1cn(-c2ccccc2)nc1-c1ccccc1)c1nc2ccccc2[nH]1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 8 of 8 chemicals

(2Z)-2-(1H-Benzimidazol-2-yl)-3-(3-(3,4-dimethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)-2-propenenitrile chemical structure, C27H21N5O2, CAS 391659-83-9
(2Z)-2-(1H-Benzimidazol-2-yl)-3-(3-(3,4-dimethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)-2-propenenitrile
CAS 391659-83-9C27H21N5O2
3-{4-[(E)-2-(1H-Benzimidazol-2-yl)-2-cyanoethenyl]-1-phenyl-1H-pyrazol-3-yl}-N,N-diethylbenzenesulfonamide chemical structure, C29H26N6O2S, CAS 1008885-16-2
3-{4-[(E)-2-(1H-Benzimidazol-2-yl)-2-cyanoethenyl]-1-phenyl-1H-pyrazol-3-yl}-N,N-diethylbenzenesulfonamide
CAS 1008885-16-2C29H26N6O2S
(Z)-2-(1H-Benzo[d]imidazol-2-yl)-3-(3-(4-methoxy-2-methylphenyl)-1-phenyl-1H-pyrazol-4-yl)acrylonitrile chemical structure, C27H21N5O, CAS 957038-98-1
(Z)-2-(1H-Benzo[d]imidazol-2-yl)-3-(3-(4-methoxy-2-methylphenyl)-1-phenyl-1H-pyrazol-4-yl)acrylonitrile
CAS 957038-98-1C27H21N5O
(2Z)-3-(3-(3,4-Dimethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)-2-(1-methyl-1H-benzimidazol-2-yl)-2-propenenitrile chemical structure, C28H23N5O2, CAS 623935-69-3
(2Z)-3-(3-(3,4-Dimethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)-2-(1-methyl-1H-benzimidazol-2-yl)-2-propenenitrile
CAS 623935-69-3C28H23N5O2
(2Z)-2-(1H-Benzimidazol-2-yl)-3-{3-[4-(ethylsulfanyl)phenyl]-1-phenyl-1H-pyrazol-4-yl}prop-2-enenitrile chemical structure, C27H21N5S, CAS 1008877-58-4
(2Z)-2-(1H-Benzimidazol-2-yl)-3-{3-[4-(ethylsulfanyl)phenyl]-1-phenyl-1H-pyrazol-4-yl}prop-2-enenitrile
CAS 1008877-58-4C27H21N5S
(2Z)-3-{3-[4-(Butylsulfanyl)phenyl]-1-phenyl-1H-pyrazol-4-yl}-2-(1-methyl-1H-benzimidazol-2-yl)prop-2-enenitrile chemical structure, C30H27N5S, CAS 1008879-89-7
(2Z)-3-{3-[4-(Butylsulfanyl)phenyl]-1-phenyl-1H-pyrazol-4-yl}-2-(1-methyl-1H-benzimidazol-2-yl)prop-2-enenitrile
CAS 1008879-89-7C30H27N5S
(2Z)-3-[3-(3-Chloro-4-propoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]-2-(1-methyl-1H-benzimidazol-2-yl)prop-2-enenitrile chemical structure, C29H24ClN5O, CAS 1008880-94-1
(2Z)-3-[3-(3-Chloro-4-propoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]-2-(1-methyl-1H-benzimidazol-2-yl)prop-2-enenitrile
CAS 1008880-94-1C29H24ClN5O
2-(1H-Benzimidazol-2-yl)-3-(1,3-diphenyl-1H-pyrazol-4-yl)acrylonitrile chemical structure, C25H17N5, CAS 391659-80-6
2-(1H-Benzimidazol-2-yl)-3-(1,3-diphenyl-1H-pyrazol-4-yl)acrylonitrile
CAS 391659-80-6C25H17N5