Murcko scaffold
2,5-Piperazinedione scaffold
354 chemicals on CompoundList share this ring system.
- Rings
- 1
- Scaffold atoms
- 8
- Chemicals
- 354
- With full pages
- 51
Scaffold SMILES
O=C1CNC(=O)CN1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 354 chemicals
Cyclo(leucylglycine)
CAS 5815-67-8C8H14N2O2
2,5-Piperazinedione
CAS 106-57-0C4H6N2O2
1,4-Dimethylpiperazine-2,5-dione
CAS 5076-82-4C6H10N2O2
2,5-Piperazinedione, 1,4-bis(hydroxymethyl)-
CAS 7383-56-4C6H10N2O4
3,6-Dimethylpiperazine-2,5-dione
CAS 5625-46-7C6H10N2O2
Cyclo(alanyl-glycyl)
CAS 6062-46-0C5H8N2O2
Cairomycin A
CAS 78859-46-8C9H14N2O4
2,5-Piperazinedione, 3,6-bis(2-methylpropyl)-
CAS 1436-27-7C12H22N2O2
3,6-Bis(hydroxymethyl)-2,5-piperazinedione
CAS 5625-41-2C6H10N2O4
3-(1-Methylethyl)-6-(2-methylpropyl)-2,5-piperazinedione
CAS 5625-50-3C11H20N2O2
3-Isopropyl-2,5-piperazine-dione
CAS 14771-77-8C7H12N2O2
Cyclo(alanylalanyl)
CAS 5845-61-4C6H10N2O2
3,6-Bis(2-(methylthio)ethyl)-2,5-piperazinedione
CAS 36963-02-7C10H18N2O2S2
2,5-Piperazinedione, 1,4-dichloro-3,3,6,6-tetramethyl-
CAS 57020-34-5C8H12Cl2N2O2
Cyclo(arginylglycyl)
CAS 74838-82-7C8H15N5O2
Cyclo(L-leucyl-L-leucyl)
CAS 952-45-4C12H22N2O2
Cyclo(di(threonine))
CAS 54617-73-1C8H14N2O4
Cyclo-methionylglycine
CAS 61243-37-6C7H12N2O2S
3,6-Bis(2-chloroethyl)piperazine-2,5-dione
CAS 5394-22-9C8H12Cl2N2O2
3,3,6,6-Tetramethylpiperazine-2,5-dione
CAS 4512-46-3C8H14N2O2
3,6-Bis(2-hydroxyethyl)piperazine-2,5-dione
CAS 50975-79-6C8H14N2O4
1-(Hydroxymethyl)-3,6-diisobutylpiperazine-2,5-dione
CAS 91973-10-3C13H24N2O3
Ethyl 3,6-dioxopiperazine-2-carboxylate
CAS 7149-63-5C7H10N2O4
1-Methylpiperazine-2,5-dione
CAS 5625-52-5C5H8N2O2
- 3,6-Dibutylpiperazine-2,5-dione10183-41-2C12H22N2O2
- 1,4-Dichloropiperazine-2,5-dione37636-52-5C4H4Cl2N2O2
- 1,4-Bis(chloromethyl)piperazine-2,5-dione64028-43-9C6H8Cl2N2O2
- 3,6-Bis(chloromethyl)piperazine-2,5-dione15948-95-5C6H8Cl2N2O2
- S-(5-Acetylsulfanyl-1,4-dimethyl-3,6-dioxopiperazin-2-yl) ethanethioate19552-97-7C10H14N2O4S2
- 3,6-Bis(ethylsulfanyl)-1,4-dimethylpiperazine-2,5-dione33022-56-9C10H18N2O2S2
- Dimethyl 2,5-dioxopiperazine-1,4-dicarbodithioate71408-31-6C8H10N2O2S4
- 3-Hydroxypiperazine-2,5-dione127605-71-4C4H6N2O3
- 3,6-Diethoxypiperazine-2,5-dione80478-54-2C8H14N2O4
- 3,6-Dioxopiperazine-2,5-diyl diacetate80478-60-0C8H10N2O6
- 3-(Hydroxymethyl)-3-methoxy-1,4-dimethylpiperazine-2,5-dione78877-87-9C8H14N2O4
- Ethyl 5-methyl-3,6-dioxopiperazine-2-carboxylate63891-87-2C8H12N2O4
- (5-Carboxymethyl-3,6-dioxo-piperazin-2-yl)-acetic acid6560-37-8C8H10N2O6
- Ethyl 2-(3,6-dioxopiperazin-2-yl)acetate150502-31-1C8H12N2O4
- Valylvaline anhydride5625-44-5C10H18N2O2
- 1,4-Diacetyl-2,5-piperazinedione3027-05-2C8H10N2O4
- 3-(Hydroxymethyl)piperazine-2,5-dione89181-64-6C5H8N2O3
- 3-Ethyl-6-(2-methylpropyl)piperazine-2,5-dione56771-93-8C10H18N2O2
- 2,5-Piperazinedione, 1,4-bis(trimethylsilyl)-3553-95-5C10H22N2O2Si2
- N,N'-[(3,6-Dioxopiperazine-2,5-diyl)di(propane-3,1-diyl)]diacetamide21028-09-1C14H24N4O4
- Alanine anhydride, trans-(A+-)-35590-65-9C6H10N2O2
- 1 suppliersD-Alanine anhydride23927-13-1C6H10N2O2
- Rhodotorulic acid18928-00-2C14H24N4O6
- 1,4-Dihydroxy-3,3,6,6-tetramethylpiperazine-2,5-dione88571-75-9C8H14N2O4
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold O=c1cccc[nH]1](/scaffold/UBQKCCHYAOITMY-UHFFFAOYSA-N/structure.svg)
