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Murcko scaffold

Ring system with 3 rings and 16 atoms

19 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 16
Chemicals: 19
With full pages: 3

Scaffold SMILES

O=C(Nc1cc2c(s1)CCC2)c1ccn[nH]1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(Nc1cc2c(s1)CCC2)c1ccn[nH]1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 19 of 19 chemicals

N-(3-Carbamoyl-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-4-chloro-2-methyl-3-pyrazolecarboxamide chemical structure, C13H13ClN4O2S, CAS 515829-40-0

N-(3-Carbamoyl-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-4-chloro-2-methyl-3-pyrazolecarboxamide

CAS 515829-40-0C₁₃H₁₃ClN₄O₂S

N-(3-Cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-1-methyl-4-nitropyrazole-3-carboxamide chemical structure, C13H11N5O3S, CAS 354577-14-3

N-(3-Cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-1-methyl-4-nitropyrazole-3-carboxamide

CAS 354577-14-3C₁₃H₁₁N₅O₃S

4-Bromo-N-(3-carbamoyl-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-1,5-dimethylpyrazole-3-carboxamide chemical structure, C14H15BrN4O2S, CAS 515831-62-6

4-Bromo-N-(3-carbamoyl-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-1,5-dimethylpyrazole-3-carboxamide

CAS 515831-62-6C₁₄H₁₅BrN₄O₂S

N-(3-Cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-4-iodo-2-methylpyrazole-3-carboxamide chemical structure, C13H11IN4OS, CAS 514219-90-0

N-(3-Cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-4-iodo-2-methylpyrazole-3-carboxamide

CAS 514219-90-0C₁₃H₁₁IN₄OS

Ethyl 2-(1-methyl-1H-pyrazole-5-carboxamido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C15H17N3O3S, CAS 496010-92-5

Ethyl 2-(1-methyl-1H-pyrazole-5-carboxamido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate

CAS 496010-92-5C₁₅H₁₇N₃O₃S

Ethyl 5-[(3-ethoxycarbonyl-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)carbamoyl]-1-methylpyrazole-3-carboxylate chemical structure, C18H21N3O5S, CAS 512808-48-9

Ethyl 5-[(3-ethoxycarbonyl-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)carbamoyl]-1-methylpyrazole-3-carboxylate

CAS 512808-48-9C₁₈H₂₁N₃O₅S

Ethyl 5-[(3-carbamoyl-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)carbamoyl]-1-methylpyrazole-3-carboxylate chemical structure, C16H18N4O4S, CAS 512808-68-3

Ethyl 5-[(3-carbamoyl-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)carbamoyl]-1-methylpyrazole-3-carboxylate

CAS 512808-68-3C₁₆H₁₈N₄O₄S

Methyl 2-{[(1-methyl-1H-pyrazol-3-yl)carbonyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C14H15N3O3S, CAS 514220-38-3

Methyl 2-{[(1-methyl-1H-pyrazol-3-yl)carbonyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate

CAS 514220-38-3C₁₄H₁₅N₃O₃S

N-(3-Carbamoyl-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-1-(difluoromethyl)pyrazole-3-carboxamide chemical structure, C13H12F2N4O2S, CAS 1005581-82-7

N-(3-Carbamoyl-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-1-(difluoromethyl)pyrazole-3-carboxamide

CAS 1005581-82-7C₁₃H₁₂F₂N₄O₂S

N-(3-Carbamoyl-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-1-methyl-1H-pyrazole-3-carboxamide chemical structure, C13H14N4O2S, CAS 1005583-76-5

N-(3-Carbamoyl-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-1-methyl-1H-pyrazole-3-carboxamide

CAS 1005583-76-5C₁₃H₁₄N₄O₂S

N-(3-Carbamoyl-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-1-methyl-5-(trifluoromethyl)pyrazole-3-carboxamide chemical structure, C14H13F3N4O2S, CAS 1005607-38-4

N-(3-Carbamoyl-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-1-methyl-5-(trifluoromethyl)pyrazole-3-carboxamide

CAS 1005607-38-4C₁₄H₁₃F₃N₄O₂S

Methyl 2-({[1-(difluoromethyl)-1H-pyrazol-3-yl]carbonyl}amino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C14H13F2N3O3S, CAS 1005639-94-0

Methyl 2-({[1-(difluoromethyl)-1H-pyrazol-3-yl]carbonyl}amino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate

CAS 1005639-94-0C₁₄H₁₃F₂N₃O₃S

N-(3-Carbamoyl-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-1-ethyl-4-nitropyrazole-3-carboxamide chemical structure, C14H15N5O4S, CAS 1005633-01-1

N-(3-Carbamoyl-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-1-ethyl-4-nitropyrazole-3-carboxamide

CAS 1005633-01-1C₁₄H₁₅N₅O₄S

Ethyl 2-(1,3-dimethyl-1H-pyrazole-5-carboxamido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C16H19N3O3S, CAS 1013795-84-0

Ethyl 2-(1,3-dimethyl-1H-pyrazole-5-carboxamido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate

CAS 1013795-84-0C₁₆H₁₉N₃O₃S

Ethyl 2-({[1-(difluoromethyl)-5-methyl-1H-pyrazol-3-yl]carbonyl}amino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C16H17F2N3O3S, CAS 1005701-01-8

Ethyl 2-({[1-(difluoromethyl)-5-methyl-1H-pyrazol-3-yl]carbonyl}amino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate

CAS 1005701-01-8C₁₆H₁₇F₂N₃O₃S

N-(3-Carbamoyl-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-1-methyl-1H-pyrazole-5-carboxamide chemical structure, C13H14N4O2S, CAS 1170961-39-3

N-(3-Carbamoyl-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-1-methyl-1H-pyrazole-5-carboxamide

CAS 1170961-39-3C₁₃H₁₄N₄O₂S

Methyl 2-(1-methyl-1H-pyrazole-5-carboxamido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C14H15N3O3S, CAS 1171806-16-8

Methyl 2-(1-methyl-1H-pyrazole-5-carboxamido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate

CAS 1171806-16-8C₁₄H₁₅N₃O₃S

N-(3-Cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-1,4-dimethyl-1H-pyrazole-3-carboxamide chemical structure, C14H14N4OS, CAS 1203370-02-8

N-(3-Cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-1,4-dimethyl-1H-pyrazole-3-carboxamide

CAS 1203370-02-8C₁₄H₁₄N₄OS

N-(3-Cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-1,4-dimethyl-1H-pyrazole-5-carboxamide chemical structure, C14H14N4OS, CAS 1251610-05-5

N-(3-Cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-1,4-dimethyl-1H-pyrazole-5-carboxamide

CAS 1251610-05-5C₁₄H₁₄N₄OS