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Murcko scaffold

Ring system with 3 rings and 16 atoms

17 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 16
Chemicals: 17
With full pages: 2

Scaffold SMILES

O=C(Nc1cc2c(s1)CCC2)c1cccs1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(Nc1cc2c(s1)CCC2)c1cccs1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 17 of 17 chemicals

Ethyl 2-[(2-thienylcarbonyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C15H15NO3S2, CAS 189067-62-7

Ethyl 2-[(2-thienylcarbonyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate

CAS 189067-62-7C₁₅H₁₅NO₃S₂

2-[(Thien-2-ylcarbonyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylic acid chemical structure, C13H11NO3S2, CAS 315694-28-1

2-[(Thien-2-ylcarbonyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylic acid

CAS 315694-28-1C₁₃H₁₁NO₃S₂

N,N-Diethyl-2-(thiophene-2-carbonylamino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide chemical structure, C17H20N2O2S2, CAS 331718-90-2

N,N-Diethyl-2-(thiophene-2-carbonylamino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide

CAS 331718-90-2C₁₇H₂₀N₂O₂S₂

Methyl 2-(5-chlorothiophene-2-carboxamido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C14H12ClNO3S2, CAS 477570-32-4

Methyl 2-(5-chlorothiophene-2-carboxamido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate

CAS 477570-32-4C₁₄H₁₂ClNO₃S₂

2-(Thiophene-2-carbonylamino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide chemical structure, C13H12N2O2S2, CAS 312917-62-7

2-(Thiophene-2-carbonylamino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide

CAS 312917-62-7C₁₃H₁₂N₂O₂S₂

Methyl 2-(thiophene-2-carbonylamino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C14H13NO3S2, CAS 324546-11-4

Methyl 2-(thiophene-2-carbonylamino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate

CAS 324546-11-4C₁₄H₁₃NO₃S₂

N-(3-Cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-3-methylthiophene-2-carboxamide chemical structure, C14H12N2OS2, CAS 729575-54-6

N-(3-Cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-3-methylthiophene-2-carboxamide

CAS 729575-54-6C₁₄H₁₂N₂OS₂

Dimethyl 2-[(thiophen-2-ylcarbonyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3,4-dicarboxylate chemical structure, C16H15NO5S2, CAS 370853-99-9

Dimethyl 2-[(thiophen-2-ylcarbonyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3,4-dicarboxylate

CAS 370853-99-9C₁₆H₁₅NO₅S₂

Ethyl 2-(5-nitrothiophene-2-carboxamido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C15H14N2O5S2, CAS 391225-86-8

Ethyl 2-(5-nitrothiophene-2-carboxamido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate

CAS 391225-86-8C₁₅H₁₄N₂O₅S₂

5-Chloro-N-(3-cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)thiophene-2-carboxamide chemical structure, C13H9ClN2OS2, CAS 313704-09-5

5-Chloro-N-(3-cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)thiophene-2-carboxamide

CAS 313704-09-5C₁₃H₉ClN₂OS₂

Ethyl 2-(5-chlorothiophene-2-carboxamido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C15H14ClNO3S2, CAS 325987-37-9

Ethyl 2-(5-chlorothiophene-2-carboxamido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate

CAS 325987-37-9C₁₅H₁₄ClNO₃S₂

2-(5-Chlorothiophene-2-carboxamido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide chemical structure, C13H11ClN2O2S2, CAS 391225-66-4

2-(5-Chlorothiophene-2-carboxamido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide

CAS 391225-66-4C₁₃H₁₁ClN₂O₂S₂

Ethyl 2-(5-bromothiophene-2-carboxamido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C15H14BrNO3S2, CAS 391224-24-1

Ethyl 2-(5-bromothiophene-2-carboxamido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate

CAS 391224-24-1C₁₅H₁₄BrNO₃S₂

N-(3-Cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)thiophene-2-carboxamide chemical structure, C13H10N2OS2, CAS 315232-42-9

N-(3-Cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)thiophene-2-carboxamide

CAS 315232-42-9C₁₃H₁₀N₂OS₂

2-(5-Bromothiophene-2-carboxamido)-N-methyl-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide chemical structure, C14H13BrN2O2S2, CAS 893095-13-1

2-(5-Bromothiophene-2-carboxamido)-N-methyl-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide

CAS 893095-13-1C₁₄H₁₃BrN₂O₂S₂

2-(5-Chlorothiophene-2-carboxamido)-N-methyl-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide chemical structure, C14H13ClN2O2S2, CAS 893095-20-0

2-(5-Chlorothiophene-2-carboxamido)-N-methyl-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide

CAS 893095-20-0C₁₄H₁₃ClN₂O₂S₂

N-(3-Cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-5-fluorothiophene-2-carboxamide chemical structure, C13H9FN2OS2, CAS 1855890-89-9

N-(3-Cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-5-fluorothiophene-2-carboxamide

CAS 1855890-89-9C₁₃H₉FN₂OS₂