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Murcko scaffold

Ring system with 3 rings and 15 atoms

22 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
15
Chemicals
22
With full pages
3
Scaffold SMILES

O=C(Nc1cc2c(s1)CCCC2)C1CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1cc2c(s1)CCCC2)C1CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 22 of 22 chemicals

2-((Cyclopropylcarbonyl)amino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C13H16N2O2S, CAS 329221-38-7
2-((Cyclopropylcarbonyl)amino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 329221-38-7C13H16N2O2S
Methyl 2-[(cyclopropylcarbonyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate chemical structure, C14H17NO3S, CAS 433688-89-2
Methyl 2-[(cyclopropylcarbonyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
CAS 433688-89-2C14H17NO3S
N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)cyclopropanecarboxamide chemical structure, C13H14N2OS, CAS 355000-40-7
N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)cyclopropanecarboxamide
CAS 355000-40-7C13H14N2OS
Ethyl 2-[(cyclopropylcarbonyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate chemical structure, C15H19NO3S, CAS 312528-58-8
Ethyl 2-[(cyclopropylcarbonyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
CAS 312528-58-8C15H19NO3S
Isopropyl 2-{[(2,2,3,3-tetramethylcyclopropyl)carbonyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate chemical structure, C20H29NO3S, CAS 352702-22-8
Isopropyl 2-{[(2,2,3,3-tetramethylcyclopropyl)carbonyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
CAS 352702-22-8C20H29NO3S
AG-690/36932156 chemical structure, C17H23NO3S, CAS 5564-17-0
AG-690/36932156
CAS 5564-17-0C17H23NO3S
Methyl 2-[[3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarbonyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate chemical structure, C18H21Cl2NO3S, CAS 297146-50-0
Methyl 2-[[3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarbonyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
CAS 297146-50-0C18H21Cl2NO3S
2-(Cyclopropanecarboxamido)-6-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide chemical structure, C14H18N2O2S, CAS 354544-70-0
2-(Cyclopropanecarboxamido)-6-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide
CAS 354544-70-0C14H18N2O2S
Methyl 2-{[(2,2-dichloro-1-methylcyclopropyl)carbonyl]amino}-6-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate chemical structure, C16H19Cl2NO3S, CAS 444905-39-9
Methyl 2-{[(2,2-dichloro-1-methylcyclopropyl)carbonyl]amino}-6-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
CAS 444905-39-9C16H19Cl2NO3S
2-({[3-(2,2-Dichloroethenyl)-2,2-dimethylcyclopropyl]carbonyl}amino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C17H20Cl2N2O2S, CAS 297146-34-0
2-({[3-(2,2-Dichloroethenyl)-2,2-dimethylcyclopropyl]carbonyl}amino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 297146-34-0C17H20Cl2N2O2S
Propan-2-yl 2-[[3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarbonyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate chemical structure, C20H25Cl2NO3S, CAS 309276-89-9
Propan-2-yl 2-[[3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarbonyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
CAS 309276-89-9C20H25Cl2NO3S
N-[3-Cyano-6-(2-methylbutan-2-yl)-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-2,2,3,3-tetramethylcyclopropane-1-carboxamide chemical structure, C22H32N2OS, CAS 445025-70-7
N-[3-Cyano-6-(2-methylbutan-2-yl)-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-2,2,3,3-tetramethylcyclopropane-1-carboxamide
CAS 445025-70-7C22H32N2OS
Isopropyl 2-{[(2,2-dichloro-1-methylcyclopropyl)carbonyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate chemical structure, C17H21Cl2NO3S, CAS 445017-62-9
Isopropyl 2-{[(2,2-dichloro-1-methylcyclopropyl)carbonyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
CAS 445017-62-9C17H21Cl2NO3S
Methyl 2-[(2,2-dibromo-1-methylcyclopropanecarbonyl)amino]-6-(2-methylbutan-2-yl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate chemical structure, C20H27Br2NO3S, CAS 444932-15-4
Methyl 2-[(2,2-dibromo-1-methylcyclopropanecarbonyl)amino]-6-(2-methylbutan-2-yl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
CAS 444932-15-4C20H27Br2NO3S
2,2-Dibromo-N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-1-methylcyclopropanecarboxamide chemical structure, C14H14Br2N2OS, CAS 445020-63-3
2,2-Dibromo-N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-1-methylcyclopropanecarboxamide
CAS 445020-63-3C14H14Br2N2OS
2-[(2,2-Dichloro-1-methylcyclopropanecarbonyl)amino]-6-propyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C17H22Cl2N2O2S, CAS 445016-85-3
2-[(2,2-Dichloro-1-methylcyclopropanecarbonyl)amino]-6-propyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 445016-85-3C17H22Cl2N2O2S
N-(3-Cyano-5-methyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)cyclopropanecarboxamide chemical structure, C14H16N2OS, CAS 476278-39-4
N-(3-Cyano-5-methyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)cyclopropanecarboxamide
CAS 476278-39-4C14H16N2OS
Methyl 2-{[(2,2-dichloro-1-methylcyclopropyl)carbonyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate chemical structure, C15H17Cl2NO3S, CAS 445016-78-4
Methyl 2-{[(2,2-dichloro-1-methylcyclopropyl)carbonyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
CAS 445016-78-4C15H17Cl2NO3S
Methyl 6-methyl-2-{[(2,2,3,3-tetramethylcyclopropyl)carbonyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate chemical structure, C19H27NO3S, CAS 353789-87-4
Methyl 6-methyl-2-{[(2,2,3,3-tetramethylcyclopropyl)carbonyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
CAS 353789-87-4C19H27NO3S
2-(Cyclopropanecarboxamido)-N-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide chemical structure, C14H18N2O2S, CAS 848330-89-2
2-(Cyclopropanecarboxamido)-N-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide
CAS 848330-89-2C14H18N2O2S
2-(Cyclopropanecarboxamido)-N,6-dimethyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide chemical structure, C15H20N2O2S, CAS 892980-50-6
2-(Cyclopropanecarboxamido)-N,6-dimethyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide
CAS 892980-50-6C15H20N2O2S
Ethyl 2-cyclopropaneamido-4,5,6,7-tetrahydro-1-benzothiophene-5-carboxylate chemical structure, C15H19NO3S, CAS 2407479-98-3
Ethyl 2-cyclopropaneamido-4,5,6,7-tetrahydro-1-benzothiophene-5-carboxylate
CAS 2407479-98-3C15H19NO3S