Murcko scaffold
Ring system with 3 rings and 25 atoms
56 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 25
- Chemicals
- 56
- With full pages
- 11
Scaffold SMILES
O=C(CN(c1ccccc1)S(=O)(=O)c1ccsc1)Nc1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 56 chemicals
![Methyl 3-[(4-chlorophenyl)({[(2-methylphenyl)carbamoyl]methyl})sulfamoyl]thiophene-2-carboxylate chemical structure, C21H19ClN2O5S2, CAS 941979-23-3](/s/PIGJQUUFNNHSJF-UHFFFAOYSA-N.svg)
Methyl 3-[(4-chlorophenyl)({[(2-methylphenyl)carbamoyl]methyl})sulfamoyl]thiophene-2-carboxylate
CAS 941979-23-3C21H19ClN2O5S2
![Methyl 3-[(4-chlorophenyl)({[(4-ethylphenyl)carbamoyl]methyl})sulfamoyl]thiophene-2-carboxylate chemical structure, C22H21ClN2O5S2, CAS 946235-24-1](/s/JDIUXXCKPHQQKZ-UHFFFAOYSA-N.svg)
Methyl 3-[(4-chlorophenyl)({[(4-ethylphenyl)carbamoyl]methyl})sulfamoyl]thiophene-2-carboxylate
CAS 946235-24-1C22H21ClN2O5S2
![Methyl 3-[(4-chlorophenyl)({[(3,5-dimethylphenyl)carbamoyl]methyl})sulfamoyl]thiophene-2-carboxylate chemical structure, C22H21ClN2O5S2, CAS 941979-26-6](/s/XYWBPYAPNUMZFY-UHFFFAOYSA-N.svg)
Methyl 3-[(4-chlorophenyl)({[(3,5-dimethylphenyl)carbamoyl]methyl})sulfamoyl]thiophene-2-carboxylate
CAS 941979-26-6C22H21ClN2O5S2
![Methyl 3-[(3,4-dimethylphenyl)({[(3-ethylphenyl)carbamoyl]methyl})sulfamoyl]thiophene-2-carboxylate chemical structure, C24H26N2O5S2, CAS 941918-91-8](/s/IGSUUHIXLNBAMH-UHFFFAOYSA-N.svg)
Methyl 3-[(3,4-dimethylphenyl)({[(3-ethylphenyl)carbamoyl]methyl})sulfamoyl]thiophene-2-carboxylate
CAS 941918-91-8C24H26N2O5S2
![Methyl 3-[(3,4-dimethylphenyl)({[(2,3-dimethylphenyl)carbamoyl]methyl})sulfamoyl]thiophene-2-carboxylate chemical structure, C24H26N2O5S2, CAS 941892-85-9](/s/RVDJKFFFPCOLOP-UHFFFAOYSA-N.svg)
Methyl 3-[(3,4-dimethylphenyl)({[(2,3-dimethylphenyl)carbamoyl]methyl})sulfamoyl]thiophene-2-carboxylate
CAS 941892-85-9C24H26N2O5S2
![Methyl 3-[(3,4-dimethylphenyl)({[(2,5-dimethylphenyl)carbamoyl]methyl})sulfamoyl]thiophene-2-carboxylate chemical structure, C24H26N2O5S2, CAS 941962-11-4](/s/UIVJYBFEJSHLDD-UHFFFAOYSA-N.svg)
Methyl 3-[(3,4-dimethylphenyl)({[(2,5-dimethylphenyl)carbamoyl]methyl})sulfamoyl]thiophene-2-carboxylate
CAS 941962-11-4C24H26N2O5S2
![Methyl 3-[(3,4-dimethylphenyl)({[(2,6-dimethylphenyl)carbamoyl]methyl})sulfamoyl]thiophene-2-carboxylate chemical structure, C24H26N2O5S2, CAS 941918-94-1](/s/GQLAMADQJJQMRO-UHFFFAOYSA-N.svg)
Methyl 3-[(3,4-dimethylphenyl)({[(2,6-dimethylphenyl)carbamoyl]methyl})sulfamoyl]thiophene-2-carboxylate
CAS 941918-94-1C24H26N2O5S2
![Methyl 3-({[(2,5-difluorophenyl)carbamoyl]methyl}(3,4-dimethylphenyl)sulfamoyl)thiophene-2-carboxylate chemical structure, C22H20F2N2O5S2, CAS 946235-28-5](/s/SAWWGXKVGWNTMI-UHFFFAOYSA-N.svg)
Methyl 3-({[(2,5-difluorophenyl)carbamoyl]methyl}(3,4-dimethylphenyl)sulfamoyl)thiophene-2-carboxylate
CAS 946235-28-5C22H20F2N2O5S2
![Methyl 3-[(3,4-dimethylphenyl)({[(3-fluoro-4-methylphenyl)carbamoyl]methyl})sulfamoyl]thiophene-2-carboxylate chemical structure, C23H23FN2O5S2, CAS 946384-99-2](/s/BTJJMRLIADVKAZ-UHFFFAOYSA-N.svg)
Methyl 3-[(3,4-dimethylphenyl)({[(3-fluoro-4-methylphenyl)carbamoyl]methyl})sulfamoyl]thiophene-2-carboxylate
CAS 946384-99-2C23H23FN2O5S2
![Methyl 3-({[(4-methylphenyl)carbamoyl]methyl}(phenyl)sulfamoyl)thiophene-2-carboxylate chemical structure, C21H20N2O5S2, CAS 895264-00-3](/s/DALUWOTVASMNBL-UHFFFAOYSA-N.svg)
Methyl 3-({[(4-methylphenyl)carbamoyl]methyl}(phenyl)sulfamoyl)thiophene-2-carboxylate
CAS 895264-00-3C21H20N2O5S2
![Methyl 3-[{2-[(2-ethylphenyl)amino]-2-oxoethyl}(phenyl)sulfamoyl]thiophene-2-carboxylate chemical structure, C22H22N2O5S2, CAS 895264-42-3](/s/FBEQCKUMEDRLJK-UHFFFAOYSA-N.svg)
Methyl 3-[{2-[(2-ethylphenyl)amino]-2-oxoethyl}(phenyl)sulfamoyl]thiophene-2-carboxylate
CAS 895264-42-3C22H22N2O5S2
![Methyl 3-({[(2-fluorophenyl)carbamoyl]methyl}(phenyl)sulfamoyl)thiophene-2-carboxylate chemical structure, C20H17FN2O5S2, CAS 895264-77-4](/s/XFRWPZILBBFHJP-UHFFFAOYSA-N.svg)
Methyl 3-({[(2-fluorophenyl)carbamoyl]methyl}(phenyl)sulfamoyl)thiophene-2-carboxylate
CAS 895264-77-4C20H17FN2O5S2
![Methyl 3-{phenyl[(phenylcarbamoyl)methyl]sulfamoyl}thiophene-2-carboxylate chemical structure, C20H18N2O5S2, CAS 895263-93-1](/s/RQAIAHSOJVUFQA-UHFFFAOYSA-N.svg)
Methyl 3-{phenyl[(phenylcarbamoyl)methyl]sulfamoyl}thiophene-2-carboxylate
CAS 895263-93-1C20H18N2O5S2
![Methyl 3-({[(4-methoxyphenyl)carbamoyl]methyl}(phenyl)sulfamoyl)thiophene-2-carboxylate chemical structure, C21H20N2O6S2, CAS 895264-56-9](/s/UDYJANBFVRDZAN-UHFFFAOYSA-N.svg)
Methyl 3-({[(4-methoxyphenyl)carbamoyl]methyl}(phenyl)sulfamoyl)thiophene-2-carboxylate
CAS 895264-56-9C21H20N2O6S2
![Methyl 3-({[(2-methoxyphenyl)carbamoyl]methyl}(phenyl)sulfamoyl)thiophene-2-carboxylate chemical structure, C21H20N2O6S2, CAS 895264-63-8](/s/YWRDKLSPDFIWBC-UHFFFAOYSA-N.svg)
Methyl 3-({[(2-methoxyphenyl)carbamoyl]methyl}(phenyl)sulfamoyl)thiophene-2-carboxylate
CAS 895264-63-8C21H20N2O6S2
![Methyl 3-({[(4-methoxyphenyl)carbamoyl]methyl}(4-methylphenyl)sulfamoyl)thiophene-2-carboxylate chemical structure, C22H22N2O6S2, CAS 895265-82-4](/s/KAERFURCLLVTPQ-UHFFFAOYSA-N.svg)
Methyl 3-({[(4-methoxyphenyl)carbamoyl]methyl}(4-methylphenyl)sulfamoyl)thiophene-2-carboxylate
CAS 895265-82-4C22H22N2O6S2
![Methyl 3-[{2-[(2-methoxyphenyl)amino]-2-oxoethyl}(4-methylphenyl)sulfamoyl]thiophene-2-carboxylate chemical structure, C22H22N2O6S2, CAS 895265-96-0](/s/LLQJFGBIMAPDTJ-UHFFFAOYSA-N.svg)
Methyl 3-[{2-[(2-methoxyphenyl)amino]-2-oxoethyl}(4-methylphenyl)sulfamoyl]thiophene-2-carboxylate
CAS 895265-96-0C22H22N2O6S2
![Methyl 3-[(3,4-dimethylphenyl)({[(4-methoxyphenyl)carbamoyl]methyl})sulfamoyl]thiophene-2-carboxylate chemical structure, C23H24N2O6S2, CAS 941918-97-4](/s/LYSMDOGJWJMBDX-UHFFFAOYSA-N.svg)
Methyl 3-[(3,4-dimethylphenyl)({[(4-methoxyphenyl)carbamoyl]methyl})sulfamoyl]thiophene-2-carboxylate
CAS 941918-97-4C23H24N2O6S2
![Methyl 3-[(4-chlorophenyl)({[(4-fluorophenyl)carbamoyl]methyl})sulfamoyl]thiophene-2-carboxylate chemical structure, C20H16ClFN2O5S2, CAS 941889-30-1](/s/BWTXTSKAKZRKNJ-UHFFFAOYSA-N.svg)
Methyl 3-[(4-chlorophenyl)({[(4-fluorophenyl)carbamoyl]methyl})sulfamoyl]thiophene-2-carboxylate
CAS 941889-30-1C20H16ClFN2O5S2
![Methyl 3-[(4-chlorophenyl)({[(3-fluoro-4-methylphenyl)carbamoyl]methyl})sulfamoyl]thiophene-2-carboxylate chemical structure, C21H18ClFN2O5S2, CAS 941979-32-4](/s/RPMLNQSUMOECAC-UHFFFAOYSA-N.svg)
Methyl 3-[(4-chlorophenyl)({[(3-fluoro-4-methylphenyl)carbamoyl]methyl})sulfamoyl]thiophene-2-carboxylate
CAS 941979-32-4C21H18ClFN2O5S2
![Methyl 3-[(4-chlorophenyl)({[(4-methylphenyl)carbamoyl]methyl})sulfamoyl]thiophene-2-carboxylate chemical structure, C21H19ClN2O5S2, CAS 941889-21-0](/s/KFXGIJAHZOBDNY-UHFFFAOYSA-N.svg)
Methyl 3-[(4-chlorophenyl)({[(4-methylphenyl)carbamoyl]methyl})sulfamoyl]thiophene-2-carboxylate
CAS 941889-21-0C21H19ClN2O5S2
![Methyl 3-[(4-chlorophenyl)({[(3-ethylphenyl)carbamoyl]methyl})sulfamoyl]thiophene-2-carboxylate chemical structure, C22H21ClN2O5S2, CAS 941936-34-1](/s/YMACUSAUAHRDKZ-UHFFFAOYSA-N.svg)
Methyl 3-[(4-chlorophenyl)({[(3-ethylphenyl)carbamoyl]methyl})sulfamoyl]thiophene-2-carboxylate
CAS 941936-34-1C22H21ClN2O5S2
![Methyl 3-[(4-chlorophenyl)({[(2,5-dimethylphenyl)carbamoyl]methyl})sulfamoyl]thiophene-2-carboxylate chemical structure, C22H21ClN2O5S2, CAS 941889-24-3](/s/YQTJVJZSXBVOLT-UHFFFAOYSA-N.svg)
Methyl 3-[(4-chlorophenyl)({[(2,5-dimethylphenyl)carbamoyl]methyl})sulfamoyl]thiophene-2-carboxylate
CAS 941889-24-3C22H21ClN2O5S2
![Methyl 3-[(4-chlorophenyl)({[(2-ethylphenyl)carbamoyl]methyl})sulfamoyl]thiophene-2-carboxylate chemical structure, C22H21ClN2O5S2, CAS 941936-37-4](/s/XHUXZFNJWNQUDM-UHFFFAOYSA-N.svg)
Methyl 3-[(4-chlorophenyl)({[(2-ethylphenyl)carbamoyl]methyl})sulfamoyl]thiophene-2-carboxylate
CAS 941936-37-4C22H21ClN2O5S2
- Methyl 3-(N-(4-chlorophenyl)-N-(2-((3,4-dimethylphenyl)amino)-2-oxoethyl)sulfamoyl)thiophene-2-carboxylate941889-27-6C22H21ClN2O5S2
- Methyl 3-[(4-chlorophenyl)({[(4-methoxyphenyl)carbamoyl]methyl})sulfamoyl]thiophene-2-carboxylate941979-29-9C21H19ClN2O6S2
- Methyl 3-[(4-chlorophenyl)({[(2-methoxyphenyl)carbamoyl]methyl})sulfamoyl]thiophene-2-carboxylate941936-40-9C21H19ClN2O6S2
- Methyl 3-[(3,4-dimethylphenyl)({[(2-methylphenyl)carbamoyl]methyl})sulfamoyl]thiophene-2-carboxylate941892-83-7C23H24N2O5S2
- Methyl 3-[(3,4-dimethylphenyl)({[(2-ethylphenyl)carbamoyl]methyl})sulfamoyl]thiophene-2-carboxylate941892-87-1C24H26N2O5S2
- Methyl 3-[(3,4-dimethylphenyl)({[(3,4-dimethylphenyl)carbamoyl]methyl})sulfamoyl]thiophene-2-carboxylate941962-13-6C24H26N2O5S2
- Methyl 3-[(3,4-dimethylphenyl)({[(4-fluorophenyl)carbamoyl]methyl})sulfamoyl]thiophene-2-carboxylate941962-15-8C22H21FN2O5S2
- Methyl 3-[(3,4-dimethylphenyl)({[(2-fluorophenyl)carbamoyl]methyl})sulfamoyl]thiophene-2-carboxylate941919-00-2C22H21FN2O5S2
- Methyl 3-({[(4-chlorophenyl)carbamoyl]methyl}(3,4-dimethylphenyl)sulfamoyl)thiophene-2-carboxylate941892-91-7C22H21ClN2O5S2
- Methyl 3-({[(3-chlorophenyl)carbamoyl]methyl}(3,4-dimethylphenyl)sulfamoyl)thiophene-2-carboxylate941962-17-0C22H21ClN2O5S2
- Methyl 3-({[(3,4-difluorophenyl)carbamoyl]methyl}(3,4-dimethylphenyl)sulfamoyl)thiophene-2-carboxylate941919-03-5C22H20F2N2O5S2
- Methyl 3-({[(3-chlorophenyl)carbamoyl]methyl}(4-methylphenyl)sulfamoyl)thiophene-2-carboxylate895266-17-8C21H19ClN2O5S2
- Methyl 3-({[(4-ethylphenyl)carbamoyl]methyl}(4-methylphenyl)sulfamoyl)thiophene-2-carboxylate895265-54-0C23H24N2O5S2
- Methyl 3-({[(2-methylphenyl)carbamoyl]methyl}(phenyl)sulfamoyl)thiophene-2-carboxylate895264-07-0C21H20N2O5S2
- Methyl 3-({[(2,3-dimethylphenyl)carbamoyl]methyl}(phenyl)sulfamoyl)thiophene-2-carboxylate895264-21-8C22H22N2O5S2
- Methyl 3-({[(2,5-dimethylphenyl)carbamoyl]methyl}(phenyl)sulfamoyl)thiophene-2-carboxylate895264-28-5C22H22N2O5S2
- Methyl 3-({[(3,5-dimethylphenyl)carbamoyl]methyl}(phenyl)sulfamoyl)thiophene-2-carboxylate895264-35-4C22H22N2O5S2
- Methyl 3-({[(3,4-dimethylphenyl)carbamoyl]methyl}(phenyl)sulfamoyl)thiophene-2-carboxylate895264-49-0C22H22N2O5S2
- Methyl 3-[{2-[(4-ethylphenyl)amino]-2-oxoethyl}(phenyl)sulfamoyl]thiophene-2-carboxylate895264-14-9C22H22N2O5S2
- Methyl 3-({[(4-fluorophenyl)carbamoyl]methyl}(phenyl)sulfamoyl)thiophene-2-carboxylate895264-70-7C20H17FN2O5S2
- Methyl 3-({[(2-chlorophenyl)carbamoyl]methyl}(phenyl)sulfamoyl)thiophene-2-carboxylate895264-91-2C20H17ClN2O5S2
- Methyl 3-({[(3-fluoro-4-methylphenyl)carbamoyl]methyl}(phenyl)sulfamoyl)thiophene-2-carboxylate895264-98-9C21H19FN2O5S2
- Methyl 3-{(4-methylphenyl)[2-oxo-2-(phenylamino)ethyl]sulfamoyl}thiophene-2-carboxylate895265-33-5C21H20N2O5S2
- Methyl 3-[(4-methylphenyl)({[(4-methylphenyl)carbamoyl]methyl})sulfamoyl]thiophene-2-carboxylate895265-40-4C22H22N2O5S2
Related scaffolds
Same ring framework with different atoms or bond orders
O=C(Cc1ccccc1)NC(CN1CCCC1)c1ccccc16 chemicals
O=C1CCCN1CN(C(=O)COc1ccccc1)c1ccccc12 chemicals
O=C(CN(c1ccccc1)S(=O)(=O)c1cccs1)Nc1ccccc12 chemicals
c1ccc(CON=C(Cn2ccnc2)c2ccccc2)cc12 chemicals
O=C(CN(c1ccccc1)S(=O)(=O)c1cccs1)NC1CCCCC12 chemicals
O=C(COc1ccccc1)N(Cc1ccco1)c1ccccc11 chemical
O=C(CN(c1ccccc1)S(=O)(=O)N1CCCC1)Nc1ccccc11 chemical
O=C(CN(c1ccccc1)S(=O)(=O)c1cnoc1)Nc1ccccc11 chemical