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Murcko scaffold

4-(Piperazin-1-yl)pyrimidine scaffold

823 chemicals on CompoundList share this ring system.

Rings: 2
Scaffold atoms: 12
Chemicals: 823
With full pages: 17

Scaffold SMILES

c1cc(N2CCNCC2)ncn1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold Open the 4-(Piperazin-1-yl)pyrimidine page

Murcko scaffold c1cc(N2CCNCC2)ncn1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 823 chemicals

4-Chloro-N-methyl-6-(4-methyl-1-piperazinyl)-5-(methylthio)-2-pyrimidinamine chemical structure, C11H18ClN5S, CAS 50335-55-2

4-Chloro-N-methyl-6-(4-methyl-1-piperazinyl)-5-(methylthio)-2-pyrimidinamine

CAS 50335-55-2C₁₁H₁₈ClN₅S

Iprozilamine chemical structure, C13H22ClN5S, CAS 55477-19-5

CAS 55477-19-5C₁₃H₂₂ClN₅S

4-Chloro-6-(4-methyl-1-piperazinyl)-5-(methylthio)-2-pyrimidinamine chemical structure, C10H16ClN5S, CAS 55921-66-9

4-Chloro-6-(4-methyl-1-piperazinyl)-5-(methylthio)-2-pyrimidinamine

CAS 55921-66-9C₁₀H₁₆ClN₅S

Pyrimidine, 4-chloro-2-(2-hydroxyethylamino)-6-(4-methylpiperazino)-5-methylthio- chemical structure, C12H20ClN5OS, CAS 55921-70-5

Pyrimidine, 4-chloro-2-(2-hydroxyethylamino)-6-(4-methylpiperazino)-5-methylthio-

CAS 55921-70-5C₁₂H₂₀ClN₅OS

Pyrimidine, 4-chloro-2-methylamino-5-methylthio-6-piperazino- chemical structure, C10H16ClN5S, CAS 55921-71-6

Pyrimidine, 4-chloro-2-methylamino-5-methylthio-6-piperazino-

CAS 55921-71-6C₁₀H₁₆ClN₅S

N-Methyl-6-(4-methylpiperazin-1-yl)-5-(methylsulfanyl)-4-propoxypyrimidin-2(1H)-imine chemical structure, C14H25N5OS, CAS 55921-72-7

N-Methyl-6-(4-methylpiperazin-1-yl)-5-(methylsulfanyl)-4-propoxypyrimidin-2(1H)-imine

CAS 55921-72-7C₁₄H₂₅N₅OS

Pyrimidine, 4-chloro-2-ethylamino-6-(4-methylpiperazino)-5-methylthio- chemical structure, C12H20ClN5S, CAS 55477-17-3

Pyrimidine, 4-chloro-2-ethylamino-6-(4-methylpiperazino)-5-methylthio-

CAS 55477-17-3C₁₂H₂₀ClN₅S

Pyrimidine, 4-chloro-2-(tert-butylamino)-6-(4-methylpiperazino)-5-methylthio- chemical structure, C14H24ClN5S, CAS 55477-20-8

Pyrimidine, 4-chloro-2-(tert-butylamino)-6-(4-methylpiperazino)-5-methylthio-

CAS 55477-20-8C₁₄H₂₄ClN₅S

Pyrimidine, 4-chloro-6-(2-hydroxyethylpiperazino)-2-methylamino-5-methylthio chemical structure, C12H20ClN5OS, CAS 55477-27-5

Pyrimidine, 4-chloro-6-(2-hydroxyethylpiperazino)-2-methylamino-5-methylthio

CAS 55477-27-5C₁₂H₂₀ClN₅OS

Pyrimidine, 2-acetylamino-4-chloro-6-(4-methylpiperazino)-5-methyl- chemical structure, C12H18ClN5O, CAS 55477-34-4

Pyrimidine, 2-acetylamino-4-chloro-6-(4-methylpiperazino)-5-methyl-

CAS 55477-34-4C₁₂H₁₈ClN₅O

2-Hydroxymethyl-4-(4-(N,N-dimethylaminosulfonyl)-1-piperazino)pyrimidine chemical structure, C11H19N5O3S, CAS 140687-51-0

2-Hydroxymethyl-4-(4-(N,N-dimethylaminosulfonyl)-1-piperazino)pyrimidine

CAS 140687-51-0C₁₁H₁₉N₅O₃S

6-(4-Methylpiperazin-1-yl)pyrimidine-2,4-diamine chemical structure, C9H16N6, CAS 4940-96-9

6-(4-Methylpiperazin-1-yl)pyrimidine-2,4-diamine

CAS 4940-96-9C₉H₁₆N₆

4-Methyl-6-(4-methylpiperazin-1-yl)pyrimidine chemical structure, C10H16N4, CAS 326007-28-7

4-Methyl-6-(4-methylpiperazin-1-yl)pyrimidine

CAS 326007-28-7C₁₀H₁₆N₄

4-Chloro-6-(4-methylpiperazin-1-yl)pyrimidin-5-amine chemical structure, C9H14ClN5, CAS 84762-68-5

4-Chloro-6-(4-methylpiperazin-1-yl)pyrimidin-5-amine

CAS 84762-68-5C₉H₁₄ClN₅

Ethyl 4-(2-amino-6-chloropyrimidin-4-yl)piperazine-1-carboxylate chemical structure, C11H16ClN5O2, CAS 860650-69-7

Ethyl 4-(2-amino-6-chloropyrimidin-4-yl)piperazine-1-carboxylate

CAS 860650-69-7C₁₁H₁₆ClN₅O₂

4-Chloro-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine chemical structure, C9H14ClN5, CAS 322691-38-3

4-Chloro-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine

CAS 322691-38-3C₉H₁₄ClN₅

Ethyl 4-(6-chloro-2-(methylsulfanyl)-4-pyrimidinyl)tetrahydro-1(2H)-pyrazinecarboxylate chemical structure, C12H17ClN4O2S, CAS 339017-78-6

Ethyl 4-(6-chloro-2-(methylsulfanyl)-4-pyrimidinyl)tetrahydro-1(2H)-pyrazinecarboxylate

CAS 339017-78-6C₁₂H₁₇ClN₄O₂S

2-Chloro-4-(4-methylpiperazin-1-yl)pyrimidine chemical structure, C9H13ClN4, CAS 749898-92-8

2-Chloro-4-(4-methylpiperazin-1-yl)pyrimidine

CAS 749898-92-8C₉H₁₃ClN₄

2-Chloro-5-fluoro-4-(4-methylpiperazin-1-yl)pyrimidine chemical structure, C9H12ClFN4, CAS 385390-91-0

2-Chloro-5-fluoro-4-(4-methylpiperazin-1-yl)pyrimidine

CAS 385390-91-0C₉H₁₂ClFN₄

6-(4-Ethylpiperazin-1-yl)-5-nitropyrimidin-4-amine chemical structure, C10H16N6O2, CAS 681271-49-8

6-(4-Ethylpiperazin-1-yl)-5-nitropyrimidin-4-amine

CAS 681271-49-8C₁₀H₁₆N₆O₂

6-(4-Methylpiperazin-1-yl)-5-nitropyrimidin-4-amine chemical structure, C9H14N6O2, CAS 406476-24-2

6-(4-Methylpiperazin-1-yl)-5-nitropyrimidin-4-amine

CAS 406476-24-2C₉H₁₄N₆O₂

2-Pyrimidinamine, 4-chloro-6-(4-methyl-1-piperazinyl)-5-(methylthio)-N-2-propenyl- chemical structure, C13H20ClN5S, CAS 59717-59-8

2-Pyrimidinamine, 4-chloro-6-(4-methyl-1-piperazinyl)-5-(methylthio)-N-2-propenyl-

CAS 59717-59-8C₁₃H₂₀ClN₅S

2-Pyrimidinamine, 4-chloro-6-(4-methyl-1-piperzinyl)-5-(methylthio)-N-pentyl- chemical structure, C15H26ClN5S, CAS 59717-61-2

2-Pyrimidinamine, 4-chloro-6-(4-methyl-1-piperzinyl)-5-(methylthio)-N-pentyl-

CAS 59717-61-2C₁₅H₂₆ClN₅S

2-Pyrimidinamine, 4-chloro-N-hexyl-6-(4-methyl-1-piperazinyl)-5-(methylthio)- chemical structure, C16H28ClN5S, CAS 59717-62-3

2-Pyrimidinamine, 4-chloro-N-hexyl-6-(4-methyl-1-piperazinyl)-5-(methylthio)-

CAS 59717-62-3C₁₆H₂₈ClN₅S