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Murcko scaffold

Ring system with 4 rings and 22 atoms

13 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
22
Chemicals
13
With full pages
2
Scaffold SMILES

O=C(Nc1cc2c(s1)CCCC2)c1cccc2ccccc12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1cc2c(s1)CCCC2)c1cccc2ccccc12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 13 of 13 chemicals

JNK inhibitor IX chemical structure, C20H16N2OS, CAS 312917-14-9
JNK inhibitor IX
CAS 312917-14-9C20H16N2OS
N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-2-ethoxynaphthalene-1-carboxamide chemical structure, C22H20N2O2S, CAS 664978-20-5
N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-2-ethoxynaphthalene-1-carboxamide
CAS 664978-20-5C22H20N2O2S
Ethyl 2-(naphthalene-1-amido)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate chemical structure, C22H21NO3S, CAS 308292-40-2
Ethyl 2-(naphthalene-1-amido)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
CAS 308292-40-2C22H21NO3S
2-[(1-Naphthylcarbonyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid chemical structure, C20H17NO3S, CAS 307512-41-0
2-[(1-Naphthylcarbonyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid
CAS 307512-41-0C20H17NO3S
2-[(5-Bromonaphthalene-1-carbonyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C20H17BrN2O2S, CAS 433971-92-7
2-[(5-Bromonaphthalene-1-carbonyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 433971-92-7C20H17BrN2O2S
2-(Naphthalene-1-carbonylamino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C20H18N2O2S, CAS 313662-66-7
2-(Naphthalene-1-carbonylamino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 313662-66-7C20H18N2O2S
5-Bromo-N-(3-cyano-6-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)naphthalene-1-carboxamide chemical structure, C21H17BrN2OS, CAS 642420-99-3
5-Bromo-N-(3-cyano-6-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)naphthalene-1-carboxamide
CAS 642420-99-3C21H17BrN2OS
Propyl 2-(1-naphthoylamino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate chemical structure, C23H23NO3S, CAS 352683-63-7
Propyl 2-(1-naphthoylamino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
CAS 352683-63-7C23H23NO3S
N-(3-Cyano-6-ethyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)naphthalene-1-carboxamide chemical structure, C22H20N2OS, CAS 557780-31-1
N-(3-Cyano-6-ethyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)naphthalene-1-carboxamide
CAS 557780-31-1C22H20N2OS
2-(1-Naphthamido)-5-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide chemical structure, C21H20N2O2S, CAS 313405-70-8
2-(1-Naphthamido)-5-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide
CAS 313405-70-8C21H20N2O2S
2-[(2-Ethoxynaphthalene-1-carbonyl)amino]-6-(2-methylbutan-2-yl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C27H32N2O3S, CAS 444909-30-2
2-[(2-Ethoxynaphthalene-1-carbonyl)amino]-6-(2-methylbutan-2-yl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 444909-30-2C27H32N2O3S
N-(3-Cyano-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)naphthalene-1-carboxamide chemical structure, C21H18N2OS, CAS 328539-92-0
N-(3-Cyano-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)naphthalene-1-carboxamide
CAS 328539-92-0C21H18N2OS
Ethyl 6-tert-butyl-2-(1-naphthoylamino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate chemical structure, C26H29NO3S, CAS 403661-87-0
Ethyl 6-tert-butyl-2-(1-naphthoylamino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
CAS 403661-87-0C26H29NO3S