Murcko scaffold
8-[3-(Benzenesulfonyl)quinolin-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane scaffold
29 chemicals on CompoundList share this ring system.
- Rings
- 5
- Scaffold atoms
- 29
- Chemicals
- 29
- With full pages
- 4
Scaffold SMILES
O=S(=O)(c1ccccc1)c1cnc2ccccc2c1N1CCC2(CC1)OCCO2
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 29 of 29 chemicals
![8-[3-(Benzenesulfonyl)-6,7-dimethoxyquinolin-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane chemical structure, C24H26N2O6S, CAS 866866-31-1](/s/LGXUIFOFQGWLOV-UHFFFAOYSA-N.svg)
8-[3-(Benzenesulfonyl)-6,7-dimethoxyquinolin-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane
CAS 866866-31-1C24H26N2O6S
![8-[3-(3,4-Dimethylphenyl)sulfonyl-6-methylquinolin-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane chemical structure, C25H28N2O4S, CAS 872209-48-8](/s/GJGIJFRZYCQHIZ-UHFFFAOYSA-N.svg)
8-[3-(3,4-Dimethylphenyl)sulfonyl-6-methylquinolin-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane
CAS 872209-48-8C25H28N2O4S
![8-[3-(Benzenesulfonyl)-6-ethylquinolin-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane chemical structure, C24H26N2O4S, CAS 866811-73-6](/s/NPFJGLSJSLSPIC-UHFFFAOYSA-N.svg)
8-[3-(Benzenesulfonyl)-6-ethylquinolin-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane
CAS 866811-73-6C24H26N2O4S
![8-[3-(Benzenesulfonyl)-6-methoxyquinolin-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane chemical structure, C23H24N2O5S, CAS 866811-80-5](/s/JVJOFVDHHSOLST-UHFFFAOYSA-N.svg)
8-[3-(Benzenesulfonyl)-6-methoxyquinolin-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane
CAS 866811-80-5C23H24N2O5S
![8-[3-(Benzenesulfonyl)-6-ethoxyquinolin-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane chemical structure, C24H26N2O5S, CAS 866811-87-2](/s/GVGAVWCJDRNBPC-UHFFFAOYSA-N.svg)
8-[3-(Benzenesulfonyl)-6-ethoxyquinolin-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane
CAS 866811-87-2C24H26N2O5S
![8-[3-(Benzenesulfonyl)-6-chloroquinolin-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane chemical structure, C22H21ClN2O4S, CAS 866811-99-6](/s/OSROBGCFVANLCD-UHFFFAOYSA-N.svg)
8-[3-(Benzenesulfonyl)-6-chloroquinolin-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane
CAS 866811-99-6C22H21ClN2O4S
![8-(6-Fluoro-3-tosylquinolin-4-yl)-1,4-dioxa-8-azaspiro[4.5]decane chemical structure, C23H23FN2O4S, CAS 866846-19-7](/s/DRJQILRRCPMNHX-UHFFFAOYSA-N.svg)
8-(6-Fluoro-3-tosylquinolin-4-yl)-1,4-dioxa-8-azaspiro[4.5]decane
CAS 866846-19-7C23H23FN2O4S
![8-(6-Chloro-3-tosylquinolin-4-yl)-1,4-dioxa-8-azaspiro[4.5]decane chemical structure, C23H23ClN2O4S, CAS 866846-22-2](/s/REXNNLPGKIOZEH-UHFFFAOYSA-N.svg)
8-(6-Chloro-3-tosylquinolin-4-yl)-1,4-dioxa-8-azaspiro[4.5]decane
CAS 866846-22-2C23H23ClN2O4S
![8-[3-(Benzenesulfonyl)-6-methylquinolin-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane chemical structure, C23H24N2O4S, CAS 872200-23-2](/s/XMUJCSFQHPYNFO-UHFFFAOYSA-N.svg)
8-[3-(Benzenesulfonyl)-6-methylquinolin-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane
CAS 872200-23-2C23H24N2O4S
![8-[3-(Benzenesulfonyl)quinolin-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane chemical structure, C22H22N2O4S, CAS 866843-10-9](/s/CDDJBTQEYIFONM-UHFFFAOYSA-N.svg)
8-[3-(Benzenesulfonyl)quinolin-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane
CAS 866843-10-9C22H22N2O4S
![8-[3-(Benzenesulfonyl)-6-fluoroquinolin-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane chemical structure, C22H21FN2O4S, CAS 866844-22-6](/s/ILIIXJYPOBIXIO-UHFFFAOYSA-N.svg)
8-[3-(Benzenesulfonyl)-6-fluoroquinolin-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane
CAS 866844-22-6C22H21FN2O4S
![8-[3-(4-Chlorobenzenesulfonyl)-6-methylquinolin-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane chemical structure, C23H23ClN2O4S, CAS 866845-12-7](/s/IKTCYASGCUJSEB-UHFFFAOYSA-N.svg)
8-[3-(4-Chlorobenzenesulfonyl)-6-methylquinolin-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane
CAS 866845-12-7C23H23ClN2O4S
![8-[3-(4-Methylphenyl)sulfonylquinolin-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane chemical structure, C23H24N2O4S, CAS 866847-32-7](/s/XIWROWGOGPCBKB-UHFFFAOYSA-N.svg)
8-[3-(4-Methylphenyl)sulfonylquinolin-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane
CAS 866847-32-7C23H24N2O4S
![8-(6-Methoxy-3-tosylquinolin-4-yl)-1,4-dioxa-8-azaspiro[4.5]decane chemical structure, C24H26N2O5S, CAS 866847-35-0](/s/HEHFNSSFAVSBLE-UHFFFAOYSA-N.svg)
8-(6-Methoxy-3-tosylquinolin-4-yl)-1,4-dioxa-8-azaspiro[4.5]decane
CAS 866847-35-0C24H26N2O5S
![8-(6-Ethyl-3-tosylquinolin-4-yl)-1,4-dioxa-8-azaspiro[4.5]decane chemical structure, C25H28N2O4S, CAS 866848-29-5](/s/HBTOGPGZPGSHGE-UHFFFAOYSA-N.svg)
8-(6-Ethyl-3-tosylquinolin-4-yl)-1,4-dioxa-8-azaspiro[4.5]decane
CAS 866848-29-5C25H28N2O4S
![8-[6-Ethoxy-3-(4-methylphenyl)sulfonylquinolin-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane chemical structure, C25H28N2O5S, CAS 866848-34-2](/s/QDCSZEPGRRVZLO-UHFFFAOYSA-N.svg)
8-[6-Ethoxy-3-(4-methylphenyl)sulfonylquinolin-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane
CAS 866848-34-2C25H28N2O5S
![8-[3-(4-Chlorophenyl)sulfonyl-6-fluoroquinolin-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane chemical structure, C22H20ClFN2O4S, CAS 866871-48-9](/s/VESQNQFXXQDPFR-UHFFFAOYSA-N.svg)
8-[3-(4-Chlorophenyl)sulfonyl-6-fluoroquinolin-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane
CAS 866871-48-9C22H20ClFN2O4S
![8-[3-(4-Chlorobenzenesulfonyl)-6-methoxyquinolin-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane chemical structure, C23H23ClN2O5S, CAS 866895-19-4](/s/BWZIWSKGOTULJL-UHFFFAOYSA-N.svg)
8-[3-(4-Chlorobenzenesulfonyl)-6-methoxyquinolin-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane
CAS 866895-19-4C23H23ClN2O5S
![8-[3-(3,4-Dimethylphenyl)sulfonylquinolin-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane chemical structure, C24H26N2O4S, CAS 872208-45-2](/s/ONWGSTSBTVOIPK-UHFFFAOYSA-N.svg)
8-[3-(3,4-Dimethylphenyl)sulfonylquinolin-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane
CAS 872208-45-2C24H26N2O4S
![8-[3-(3,4-Dimethylbenzenesulfonyl)-6-methoxyquinolin-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane chemical structure, C25H28N2O5S, CAS 867040-22-0](/s/DTJKEJZUXMZZMJ-UHFFFAOYSA-N.svg)
8-[3-(3,4-Dimethylbenzenesulfonyl)-6-methoxyquinolin-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane
CAS 867040-22-0C25H28N2O5S
![8-[6-Methoxy-3-(4-methoxybenzenesulfonyl)quinolin-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane chemical structure, C24H26N2O6S, CAS 866897-25-8](/s/SVSDOXXJTMWZIZ-UHFFFAOYSA-N.svg)
8-[6-Methoxy-3-(4-methoxybenzenesulfonyl)quinolin-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane
CAS 866897-25-8C24H26N2O6S
![8-[6-Chloro-3-(4-methoxybenzenesulfonyl)quinolin-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane chemical structure, C23H23ClN2O5S, CAS 867040-36-6](/s/CXUHBWVYLAUTMQ-UHFFFAOYSA-N.svg)
8-[6-Chloro-3-(4-methoxybenzenesulfonyl)quinolin-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane
CAS 867040-36-6C23H23ClN2O5S
![8-[6-Ethyl-3-(4-methoxybenzenesulfonyl)quinolin-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane chemical structure, C25H28N2O5S, CAS 866897-21-4](/s/CNYGYHNPZJUWJZ-UHFFFAOYSA-N.svg)
8-[6-Ethyl-3-(4-methoxybenzenesulfonyl)quinolin-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane
CAS 866897-21-4C25H28N2O5S
![8-(3-((3,4-Dimethylphenyl)sulfonyl)-6-fluoroquinolin-4-yl)-1,4-dioxa-8-azaspiro[4.5]decane chemical structure, C24H25FN2O4S, CAS 887223-21-4](/s/SBBDDONFHVWRAH-UHFFFAOYSA-N.svg)
8-(3-((3,4-Dimethylphenyl)sulfonyl)-6-fluoroquinolin-4-yl)-1,4-dioxa-8-azaspiro[4.5]decane
CAS 887223-21-4C24H25FN2O4S
- 8-[3-(4-Ethylbenzenesulfonyl)-6-methoxyquinolin-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane887223-22-5C25H28N2O5S
- 8-(3-((3,4-Dimethylphenyl)sulfonyl)-6-ethoxyquinolin-4-yl)-1,4-dioxa-8-azaspiro[4.5]decane897758-81-5C26H30N2O5S
- 8-(6-Methyl-3-tosylquinolin-4-yl)-1,4-dioxa-8-azaspiro[4.5]decane895641-50-6C24H26N2O4S
- 8-[3-(4-Ethylbenzenesulfonyl)quinolin-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane887863-87-8C24H26N2O4S
- 8-[3-(4-Ethylbenzenesulfonyl)-6-methylquinolin-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane899356-12-8C25H28N2O4S