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Murcko scaffold

Ring system with 4 rings and 20 atoms

32 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 20
Chemicals: 32
With full pages: 11

Scaffold SMILES

O=c1c(-c2nc3ccccc3[nH]2)coc2ccccc12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=c1c(-c2nc3ccccc3[nH]2)coc2ccccc12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 32 of 32 chemicals

3-(1H-Benzo[d]imidazol-2-yl)-6-chloro-4H-chromen-4-one chemical structure, C16H9ClN2O2, CAS 293740-39-3

3-(1H-Benzo[d]imidazol-2-yl)-6-chloro-4H-chromen-4-one

CAS 293740-39-3C₁₆H₉ClN₂O₂

4H-1-Benzopyran-4-one, 2-amino-3-(1H-benzimidazol-2-yl)- chemical structure, C16H11N3O2, CAS 89260-80-0

4H-1-Benzopyran-4-one, 2-amino-3-(1H-benzimidazol-2-yl)-

CAS 89260-80-0C₁₆H₁₁N₃O₂

6-Ethyl-3-(1-methyl-1H-benzimidazol-2-yl)-4-oxo-4H-chromen-7-yl acetate chemical structure, C21H18N2O4, CAS 210639-96-6

6-Ethyl-3-(1-methyl-1H-benzimidazol-2-yl)-4-oxo-4H-chromen-7-yl acetate

CAS 210639-96-6C₂₁H₁₈N₂O₄

3-(1H-Benzo[d]imidazol-2-yl)-8-((dimethylamino)methyl)-6-ethyl-7-hydroxy-4H-chromen-4-one chemical structure, C21H21N3O3, CAS 210640-04-3

3-(1H-Benzo[d]imidazol-2-yl)-8-((dimethylamino)methyl)-6-ethyl-7-hydroxy-4H-chromen-4-one

CAS 210640-04-3C₂₁H₂₁N₃O₃

3-(1H-Benzo[d]imidazol-2-yl)-8-((diethylamino)methyl)-6-ethyl-7-hydroxy-4H-chromen-4-one chemical structure, C23H25N3O3, CAS 222716-53-2

3-(1H-Benzo[d]imidazol-2-yl)-8-((diethylamino)methyl)-6-ethyl-7-hydroxy-4H-chromen-4-one

CAS 222716-53-2C₂₃H₂₅N₃O₃

8-((Diethylamino)methyl)-6-ethyl-7-hydroxy-3-(1-methyl-1H-benzo[d]imidazol-2-yl)-4H-chromen-4-one chemical structure, C24H27N3O3, CAS 222716-46-3

8-((Diethylamino)methyl)-6-ethyl-7-hydroxy-3-(1-methyl-1H-benzo[d]imidazol-2-yl)-4H-chromen-4-one

CAS 222716-46-3C₂₄H₂₇N₃O₃

8-((Dimethylamino)methyl)-6-ethyl-7-hydroxy-2-methyl-3-(1-methyl-1H-benzo[d]imidazol-2-yl)-4H-chromen-4-one chemical structure, C23H25N3O3, CAS 210640-05-4

8-((Dimethylamino)methyl)-6-ethyl-7-hydroxy-2-methyl-3-(1-methyl-1H-benzo[d]imidazol-2-yl)-4H-chromen-4-one

CAS 210640-05-4C₂₃H₂₅N₃O₃

3-(1H-Benzimidazol-2-yl)-6-ethyl-2-methyl-4-oxo-4H-chromen-7-yl acetate chemical structure, C21H18N2O4, CAS 301159-84-2

3-(1H-Benzimidazol-2-yl)-6-ethyl-2-methyl-4-oxo-4H-chromen-7-yl acetate

CAS 301159-84-2C₂₁H₁₈N₂O₄

2-Methyl-3-(1-methyl-1H-benzo[d]imidazol-2-yl)-4-oxo-4H-chromen-7-yl pivalate chemical structure, C23H22N2O4, CAS 314243-85-1

2-Methyl-3-(1-methyl-1H-benzo[d]imidazol-2-yl)-4-oxo-4H-chromen-7-yl pivalate

CAS 314243-85-1C₂₃H₂₂N₂O₄

8-((Diethylamino)methyl)-6-ethyl-7-hydroxy-2-methyl-3-(1-methyl-1H-benzo[d]imidazol-2-yl)-4H-chromen-4-one chemical structure, C25H29N3O3, CAS 222716-49-6

8-((Diethylamino)methyl)-6-ethyl-7-hydroxy-2-methyl-3-(1-methyl-1H-benzo[d]imidazol-2-yl)-4H-chromen-4-one

CAS 222716-49-6C₂₅H₂₉N₃O₃

8-[[Bis(2-methylpropyl)azaniumyl]methyl]-6-ethyl-3-(1-methylbenzimidazol-2-yl)-4-oxochromen-7-olate chemical structure, C28H35N3O3, CAS 384364-30-1

8-[[Bis(2-methylpropyl)azaniumyl]methyl]-6-ethyl-3-(1-methylbenzimidazol-2-yl)-4-oxochromen-7-olate

CAS 384364-30-1C₂₈H₃₅N₃O₃

{[7-[(2,2-Dimethylpropanoyl)oxy]-6-ethyl-3-(1-methyl-1H-benzimidazol-2-yl)-4-oxo-4H-chromen-2-yl]methoxy}acetic acid chemical structure, C27H28N2O7, CAS 864839-78-1

{[7-[(2,2-Dimethylpropanoyl)oxy]-6-ethyl-3-(1-methyl-1H-benzimidazol-2-yl)-4-oxo-4H-chromen-2-yl]methoxy}acetic acid

CAS 864839-78-1C₂₇H₂₈N₂O₇

3570-0208 [Pmid:19807662] chemical structure, C22H20N2O4, CAS 210639-90-0

3570-0208 [Pmid:19807662]

CAS 210639-90-0C₂₂H₂₀N₂O₄

6-Ethyl-3-(1-methyl-1H-benzo[d]imidazol-2-yl)-4-oxo-4H-chromen-7-yl methanesulfonate chemical structure, C20H18N2O5S, CAS 210639-97-7

6-Ethyl-3-(1-methyl-1H-benzo[d]imidazol-2-yl)-4-oxo-4H-chromen-7-yl methanesulfonate

CAS 210639-97-7C₂₀H₁₈N₂O₅S

2-((6-Ethyl-7-hydroxy-3-(1-methyl-1H-benzo[d]imidazol-2-yl)-4-oxo-4H-chromen-2-yl)methoxy)acetic acid chemical structure, C22H20N2O6, CAS 842976-34-5

2-((6-Ethyl-7-hydroxy-3-(1-methyl-1H-benzo[d]imidazol-2-yl)-4-oxo-4H-chromen-2-yl)methoxy)acetic acid

CAS 842976-34-5C₂₂H₂₀N₂O₆

6-Ethyl-7-hydroxy-3-(1-methyl-1H-benzimidazol-2-yl)-2-(trifluoromethyl)-4H-chromen-4-one chemical structure, C20H15F3N2O3, CAS 210639-84-2

6-Ethyl-7-hydroxy-3-(1-methyl-1H-benzimidazol-2-yl)-2-(trifluoromethyl)-4H-chromen-4-one

CAS 210639-84-2C₂₀H₁₅F₃N₂O₃

6-Ethyl-7-hydroxy-2-isopropyl-3-(1-methyl-1H-benzo[d]imidazol-2-yl)-4H-chromen-4-one chemical structure, C22H22N2O3, CAS 314745-53-4

6-Ethyl-7-hydroxy-2-isopropyl-3-(1-methyl-1H-benzo[d]imidazol-2-yl)-4H-chromen-4-one

CAS 314745-53-4C₂₂H₂₂N₂O₃

3-(3-(1H-Benzo[d]imidazol-2-yl)-7-hydroxy-4-oxo-4H-chromen-2-yl)propanoic acid chemical structure, C19H14N2O5, CAS 300674-43-5

3-(3-(1H-Benzo[d]imidazol-2-yl)-7-hydroxy-4-oxo-4H-chromen-2-yl)propanoic acid

CAS 300674-43-5C₁₉H₁₄N₂O₅

7-Hydroxy-2-methyl-3-(1-methyl-1H-benzo[d]imidazol-2-yl)-4H-chromen-4-one chemical structure, C18H14N2O3, CAS 307526-35-8

7-Hydroxy-2-methyl-3-(1-methyl-1H-benzo[d]imidazol-2-yl)-4H-chromen-4-one

CAS 307526-35-8C₁₈H₁₄N₂O₃

2-Ethyl-7-hydroxy-3-(1-methylbenzimidazol-2-yl)chromen-4-one chemical structure, C19H16N2O3, CAS 314745-55-6

2-Ethyl-7-hydroxy-3-(1-methylbenzimidazol-2-yl)chromen-4-one

CAS 314745-55-6C₁₉H₁₆N₂O₃

7-Hydroxy-2-isopropyl-3-(1-methyl-1H-benzo[d]imidazol-2-yl)-4H-chromen-4-one chemical structure, C20H18N2O3, CAS 505070-74-6

7-Hydroxy-2-isopropyl-3-(1-methyl-1H-benzo[d]imidazol-2-yl)-4H-chromen-4-one

CAS 505070-74-6C₂₀H₁₈N₂O₃

6-Ethyl-7-hydroxy-2-methyl-3-(1-methyl-1H-1,3-benzodiazol-2-yl)-4H-chromen-4-one chemical structure, C20H18N2O3, CAS 210639-92-2

6-Ethyl-7-hydroxy-2-methyl-3-(1-methyl-1H-1,3-benzodiazol-2-yl)-4H-chromen-4-one

CAS 210639-92-2C₂₀H₁₈N₂O₃

3-(1H-Benzimidazol-2-yl)-6-ethyl-7-hydroxy-4H-chromen-4-one chemical structure, C18H14N2O3, CAS 210639-80-8

3-(1H-Benzimidazol-2-yl)-6-ethyl-7-hydroxy-4H-chromen-4-one

CAS 210639-80-8C₁₈H₁₄N₂O₃

3-(1H-Benzimidazol-2-yl)-7-hydroxychromen-4-one chemical structure, C16H10N2O3, CAS 307526-34-7

3-(1H-Benzimidazol-2-yl)-7-hydroxychromen-4-one

CAS 307526-34-7C₁₆H₁₀N₂O₃