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Murcko scaffold

Ring system with 4 rings and 28 atoms

16 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 28
Chemicals: 16
With full pages: 10

Scaffold SMILES

S=c1[nH]nc(-c2ccccc2)n1N=Cc1ccc(OCc2ccccc2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold S=c1[nH]nc(-c2ccccc2)n1N=Cc1ccc(OCc2ccccc2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 16 of 16 chemicals

3-(4-Methoxyphenyl)-4-[(E)-(3-methoxy-4-phenylmethoxyphenyl)methylideneamino]-1H-1,2,4-triazole-5-thione chemical structure, C24H22N4O3S, CAS 420842-30-4

3-(4-Methoxyphenyl)-4-[(E)-(3-methoxy-4-phenylmethoxyphenyl)methylideneamino]-1H-1,2,4-triazole-5-thione

CAS 420842-30-4C₂₄H₂₂N₄O₃S

4-[(E)-(3-Methoxy-4-phenylmethoxyphenyl)methylideneamino]-3-(4-methylphenyl)-1H-1,2,4-triazole-5-thione chemical structure, C24H22N4O2S, CAS 420814-18-2

4-[(E)-(3-Methoxy-4-phenylmethoxyphenyl)methylideneamino]-3-(4-methylphenyl)-1H-1,2,4-triazole-5-thione

CAS 420814-18-2C₂₄H₂₂N₄O₂S

4-({(E)-[4-(Benzyloxy)phenyl]methylidene}amino)-5-(4-methylphenyl)-4H-1,2,4-triazole-3-thiol chemical structure, C23H20N4OS, CAS 430450-37-6

4-({(E)-[4-(Benzyloxy)phenyl]methylidene}amino)-5-(4-methylphenyl)-4H-1,2,4-triazole-3-thiol

CAS 430450-37-6C₂₃H₂₀N₄OS

3-(3,4-Dimethoxyphenyl)-4-[(E)-(3-methoxy-4-phenylmethoxyphenyl)methylideneamino]-1H-1,2,4-triazole-5-thione chemical structure, C25H24N4O4S, CAS 489463-72-1

3-(3,4-Dimethoxyphenyl)-4-[(E)-(3-methoxy-4-phenylmethoxyphenyl)methylideneamino]-1H-1,2,4-triazole-5-thione

CAS 489463-72-1C₂₅H₂₄N₄O₄S

3-(3,4-Dimethoxyphenyl)-4-[(E)-(4-phenylmethoxyphenyl)methylideneamino]-1H-1,2,4-triazole-5-thione chemical structure, C24H22N4O3S, CAS 497229-95-5

3-(3,4-Dimethoxyphenyl)-4-[(E)-(4-phenylmethoxyphenyl)methylideneamino]-1H-1,2,4-triazole-5-thione

CAS 497229-95-5C₂₄H₂₂N₄O₃S

3-(4-Methoxyphenyl)-4-[(E)-(4-phenylmethoxyphenyl)methylideneamino]-1H-1,2,4-triazole-5-thione chemical structure, C23H20N4O2S, CAS 420844-16-2

3-(4-Methoxyphenyl)-4-[(E)-(4-phenylmethoxyphenyl)methylideneamino]-1H-1,2,4-triazole-5-thione

CAS 420844-16-2C₂₃H₂₀N₄O₂S

4-((4-(Benzyloxy)-3-meo-benzylidene)amino)-5-(3-ME-PH)-4H-1,2,4-triazole-3-thiol chemical structure, C24H22N4O2S, CAS 478255-63-9

4-((4-(Benzyloxy)-3-meo-benzylidene)amino)-5-(3-ME-PH)-4H-1,2,4-triazole-3-thiol

CAS 478255-63-9C₂₄H₂₂N₄O₂S

4-(((E)-(4-(Benzyloxy)phenyl)methylidene)amino)-5-(3-methoxyphenyl)-4H-1,2,4-triazole-3-thiol chemical structure, C23H20N4O2S, CAS 478257-58-8

4-(((E)-(4-(Benzyloxy)phenyl)methylidene)amino)-5-(3-methoxyphenyl)-4H-1,2,4-triazole-3-thiol

CAS 478257-58-8C₂₃H₂₀N₄O₂S

4-({(E)-[4-(Benzyloxy)-3-methoxyphenyl]methylidene}amino)-5-(2-methoxyphenyl)-4H-1,2,4-triazole-3-thiol chemical structure, C24H22N4O3S, CAS 478256-56-3

4-({(E)-[4-(Benzyloxy)-3-methoxyphenyl]methylidene}amino)-5-(2-methoxyphenyl)-4H-1,2,4-triazole-3-thiol

CAS 478256-56-3C₂₄H₂₂N₄O₃S

4-({(E)-[4-(Benzyloxy)-3-methoxyphenyl]methylidene}amino)-5-(3-chlorophenyl)-4H-1,2,4-triazole-3-thiol chemical structure, C23H19ClN4O2S, CAS 478254-72-7

4-({(E)-[4-(Benzyloxy)-3-methoxyphenyl]methylidene}amino)-5-(3-chlorophenyl)-4H-1,2,4-triazole-3-thiol

CAS 478254-72-7C₂₃H₁₉ClN₄O₂S

4-((4-(Benzyloxy)benzylidene)amino)5-(2-CL-PH)4H-1,2,4-triazol-3-yl hydrosulfide chemical structure, C22H17ClN4OS, CAS 478253-78-0

4-((4-(Benzyloxy)benzylidene)amino)5-(2-CL-PH)4H-1,2,4-triazol-3-yl hydrosulfide

CAS 478253-78-0C₂₂H₁₇ClN₄OS

4-({(E)-[4-(Benzyloxy)phenyl]methylidene}amino)-5-(3-chlorophenyl)-4H-1,2,4-triazole-3-thiol chemical structure, C22H17ClN4OS, CAS 478254-60-3

4-({(E)-[4-(Benzyloxy)phenyl]methylidene}amino)-5-(3-chlorophenyl)-4H-1,2,4-triazole-3-thiol

CAS 478254-60-3C₂₂H₁₇ClN₄OS

4-({(E)-[4-(Benzyloxy)phenyl]methylidene}amino)-5-(3-methylphenyl)-4H-1,2,4-triazole-3-thiol chemical structure, C23H20N4OS, CAS 478255-49-1

4-({(E)-[4-(Benzyloxy)phenyl]methylidene}amino)-5-(3-methylphenyl)-4H-1,2,4-triazole-3-thiol

CAS 478255-49-1C₂₃H₂₀N₄OS

4-((4-(Benzyloxy)-3-meo-benzylidene)amino)-5-(3-meo-PH)4H-1,2,4-triazole-3-thiol chemical structure, C24H22N4O3S, CAS 478257-94-2

4-((4-(Benzyloxy)-3-meo-benzylidene)amino)-5-(3-meo-PH)4H-1,2,4-triazole-3-thiol

CAS 478257-94-2C₂₄H₂₂N₄O₃S

4-((4-(Benzyloxy)-3-meo-benzylidene)amino)-5-(2-CL-PH)-4H-1,2,4-triazole-3-thiol chemical structure, C23H19ClN4O2S, CAS 478253-92-8

4-((4-(Benzyloxy)-3-meo-benzylidene)amino)-5-(2-CL-PH)-4H-1,2,4-triazole-3-thiol

CAS 478253-92-8C₂₃H₁₉ClN₄O₂S

4-((4-(Benzyloxy)-3-meo-benzylidene)amino)-5-(2-F-PH)-4H-1,2,4-triazole-3-thiol chemical structure, C23H19FN4O2S, CAS 677754-65-3

4-((4-(Benzyloxy)-3-meo-benzylidene)amino)-5-(2-F-PH)-4H-1,2,4-triazole-3-thiol

CAS 677754-65-3C₂₃H₁₉FN₄O₂S