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Murcko scaffold

Ring system with 2 rings and 22 atoms

24 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
22
Chemicals
24
With full pages
10
Scaffold SMILES

O=C(CCC(=O)Nc1ccccc1)NN=Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CCC(=O)Nc1ccccc1)NN=Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 24 of 24 chemicals

4-[(4-Fluorophenyl)amino]-4-oxobutanoic acid 2-[(3-bromophenyl)methylene]hydrazide chemical structure, C17H15BrFN3O2, CAS 294653-02-4
4-[(4-Fluorophenyl)amino]-4-oxobutanoic acid 2-[(3-bromophenyl)methylene]hydrazide
CAS 294653-02-4C17H15BrFN3O2
4-{2-[(E)-1-(4-Aminophenyl)ethylidene]hydrazino}-N-(2-chlorophenyl)-4-oxobutanamide chemical structure, C18H19ClN4O2, CAS 356768-62-2
4-{2-[(E)-1-(4-Aminophenyl)ethylidene]hydrazino}-N-(2-chlorophenyl)-4-oxobutanamide
CAS 356768-62-2C18H19ClN4O2
Ethyl [2-bromo-4-({2-[4-(3-chloro-4-methylanilino)-4-oxobutanoyl]hydrazinylidene}methyl)phenoxy]acetate chemical structure, C22H23BrClN3O5, CAS 5424-69-1
Ethyl [2-bromo-4-({2-[4-(3-chloro-4-methylanilino)-4-oxobutanoyl]hydrazinylidene}methyl)phenoxy]acetate
CAS 5424-69-1C22H23BrClN3O5
N'-[(5-Bromo-2,4-dimethoxyphenyl)methylideneamino]-N-(3,4-dimethylphenyl)butanediamide chemical structure, C21H24BrN3O4, CAS 6967-20-0
N'-[(5-Bromo-2,4-dimethoxyphenyl)methylideneamino]-N-(3,4-dimethylphenyl)butanediamide
CAS 6967-20-0C21H24BrN3O4
N-(2-Chlorophenyl)-4-{[(2,6-dichlorophenyl)methylidene]hydrazinylidene}-4-hydroxybutanimidic acid chemical structure, C17H14Cl3N3O2, CAS 6966-85-4
N-(2-Chlorophenyl)-4-{[(2,6-dichlorophenyl)methylidene]hydrazinylidene}-4-hydroxybutanimidic acid
CAS 6966-85-4C17H14Cl3N3O2
N'-[(E)-Benzylideneamino]-N-(4-iodophenyl)butanediamide chemical structure, C17H16IN3O2, CAS 325999-94-8
N'-[(E)-Benzylideneamino]-N-(4-iodophenyl)butanediamide
CAS 325999-94-8C17H16IN3O2
N-(4-Bromophenyl)-4-(2-(3-nitrobenzylidene)hydrazino)-4-oxobutanamide chemical structure, C17H15BrN4O4, CAS 303084-71-1
N-(4-Bromophenyl)-4-(2-(3-nitrobenzylidene)hydrazino)-4-oxobutanamide
CAS 303084-71-1C17H15BrN4O4
N'-[(E)-(5-Bromo-2,4-dimethoxyphenyl)methylideneamino]-N-(3-chloro-2-methylphenyl)butanediamide chemical structure, C20H21BrClN3O4, CAS 328026-32-0
N'-[(E)-(5-Bromo-2,4-dimethoxyphenyl)methylideneamino]-N-(3-chloro-2-methylphenyl)butanediamide
CAS 328026-32-0C20H21BrClN3O4
N'-[(E)-(4-Cyanophenyl)methylideneamino]-N-phenylbutanediamide chemical structure, C18H16N4O2, CAS 328026-34-2
N'-[(E)-(4-Cyanophenyl)methylideneamino]-N-phenylbutanediamide
CAS 328026-34-2C18H16N4O2
N-(4-Chloro-2-methylphenyl)-N'-[(E)-1-(4-nitrophenyl)ethylideneamino]butanediamide chemical structure, C19H19ClN4O4, CAS 438472-01-6
N-(4-Chloro-2-methylphenyl)-N'-[(E)-1-(4-nitrophenyl)ethylideneamino]butanediamide
CAS 438472-01-6C19H19ClN4O4
N-(4-Bromophenyl)-4-(2-(1-(4-methylphenyl)ethylidene)hydrazino)-4-oxobutanamide chemical structure, C19H20BrN3O2, CAS 302910-48-1
N-(4-Bromophenyl)-4-(2-(1-(4-methylphenyl)ethylidene)hydrazino)-4-oxobutanamide
CAS 302910-48-1C19H20BrN3O2
4-(2-(5-BR-2,4-Dimethoxybenzylidene)hydrazino)N-(3-methylphenyl)-4-oxobutanamide chemical structure, C20H22BrN3O4, CAS 302910-37-8
4-(2-(5-BR-2,4-Dimethoxybenzylidene)hydrazino)N-(3-methylphenyl)-4-oxobutanamide
CAS 302910-37-8C20H22BrN3O4
4-(2-(3,4-Dichlorobenzylidene)hydrazino)-N-(3-methylphenyl)-4-oxobutanamide chemical structure, C18H17Cl2N3O2, CAS 302909-64-4
4-(2-(3,4-Dichlorobenzylidene)hydrazino)-N-(3-methylphenyl)-4-oxobutanamide
CAS 302909-64-4C18H17Cl2N3O2
N-(3,4-Dimethylphenyl)-4-(2-{3-nitrobenzylidene}hydrazino)-4-oxobutanamide chemical structure, C19H20N4O4, CAS 351368-91-7
N-(3,4-Dimethylphenyl)-4-(2-{3-nitrobenzylidene}hydrazino)-4-oxobutanamide
CAS 351368-91-7C19H20N4O4
N-(3-Methylphenyl)-4-(2-(1-(4-methylphenyl)ethylidene)hydrazino)-4-oxobutanamide chemical structure, C20H23N3O2, CAS 303083-62-7
N-(3-Methylphenyl)-4-(2-(1-(4-methylphenyl)ethylidene)hydrazino)-4-oxobutanamide
CAS 303083-62-7C20H23N3O2
4-(2-(3-HO-4-Methoxybenzylidene)hydrazino)-N-(3-methylphenyl)-4-oxobutanamide chemical structure, C19H21N3O4, CAS 303083-55-8
4-(2-(3-HO-4-Methoxybenzylidene)hydrazino)-N-(3-methylphenyl)-4-oxobutanamide
CAS 303083-55-8C19H21N3O4
N-(3-Methylphenyl)-4-oxo-4-(2-(1-phenylethylidene)hydrazino)butanamide chemical structure, C19H21N3O2, CAS 303084-05-1
N-(3-Methylphenyl)-4-oxo-4-(2-(1-phenylethylidene)hydrazino)butanamide
CAS 303084-05-1C19H21N3O2
4-{2-[1-(4-Methylphenyl)ethylidene]hydrazino}-4-oxo-N-phenylbutanamide chemical structure, C19H21N3O2, CAS 349630-67-7
4-{2-[1-(4-Methylphenyl)ethylidene]hydrazino}-4-oxo-N-phenylbutanamide
CAS 349630-67-7C19H21N3O2
4-(2-Benzylidenehydrazino)-N-(4-bromophenyl)-4-oxobutanamide chemical structure, C17H16BrN3O2, CAS 303083-75-2
4-(2-Benzylidenehydrazino)-N-(4-bromophenyl)-4-oxobutanamide
CAS 303083-75-2C17H16BrN3O2
N-(3-Chloro-2-methylphenyl)-4-{2-[4-(diethylamino)-2-hydroxybenzylidene]hydrazino}-4-oxobutanamide chemical structure, C22H27ClN4O3, CAS 328026-29-5
N-(3-Chloro-2-methylphenyl)-4-{2-[4-(diethylamino)-2-hydroxybenzylidene]hydrazino}-4-oxobutanamide
CAS 328026-29-5C22H27ClN4O3
4-[2-(2,4-Dihydroxybenzylidene)hydrazino]-N-(2-methylphenyl)-4-oxobutanamide chemical structure, C18H19N3O4, CAS 325998-34-3
4-[2-(2,4-Dihydroxybenzylidene)hydrazino]-N-(2-methylphenyl)-4-oxobutanamide
CAS 325998-34-3C18H19N3O4
4-[2-(5-Bromo-2-hydroxybenzylidene)hydrazino]-N-(2-methylphenyl)-4-oxobutanamide chemical structure, C18H18BrN3O3, CAS 6046-54-4
4-[2-(5-Bromo-2-hydroxybenzylidene)hydrazino]-N-(2-methylphenyl)-4-oxobutanamide
CAS 6046-54-4C18H18BrN3O3
N-(4-Bromophenyl)-4-(2-(4-HO-3-methoxybenzylidene)hydrazino)-4-oxobutanamide chemical structure, C18H18BrN3O4, CAS 302909-93-9
N-(4-Bromophenyl)-4-(2-(4-HO-3-methoxybenzylidene)hydrazino)-4-oxobutanamide
CAS 302909-93-9C18H18BrN3O4
4-[(2E)-2-(2-Hydroxy-5-methoxybenzylidene)hydrazino]-N-(4-methylphenyl)-4-oxobutanamide chemical structure, C19H21N3O4, CAS 5595-41-5
4-[(2E)-2-(2-Hydroxy-5-methoxybenzylidene)hydrazino]-N-(4-methylphenyl)-4-oxobutanamide
CAS 5595-41-5C19H21N3O4