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Murcko scaffold

Ring system with 2 rings and 22 atoms

24 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
22
Chemicals
24
With full pages
21
Scaffold SMILES

O=C(NN=CC=Cc1ccccc1)C(=O)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(NN=CC=Cc1ccccc1)C(=O)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 24 of 24 chemicals

N'-(4-Phenylbut-3-en-2-ylideneamino)-N-[4-(trifluoromethyl)phenyl]oxamide chemical structure, C19H16F3N3O2, CAS 6917-72-2
N'-(4-Phenylbut-3-en-2-ylideneamino)-N-[4-(trifluoromethyl)phenyl]oxamide
CAS 6917-72-2C19H16F3N3O2
3-[[2-[(2E)-2-[(Z)-2-Chloro-3-(4-nitrophenyl)prop-2-enylidene]hydrazinyl]-2-oxoacetyl]amino]benzoic acid chemical structure, C18H13ClN4O6, CAS 317842-02-7
3-[[2-[(2E)-2-[(Z)-2-Chloro-3-(4-nitrophenyl)prop-2-enylidene]hydrazinyl]-2-oxoacetyl]amino]benzoic acid
CAS 317842-02-7C18H13ClN4O6
N-(4-Methylphenyl)-2-oxo-2-(2-(3-phenyl-2-propenylidene)hydrazino)acetamide chemical structure, C18H17N3O2, CAS 769146-89-6
N-(4-Methylphenyl)-2-oxo-2-(2-(3-phenyl-2-propenylidene)hydrazino)acetamide
CAS 769146-89-6C18H17N3O2
N-(2,3-Dichlorophenyl)-2-oxo-2-(2-(3-phenyl-2-propenylidene)hydrazino)acetamide chemical structure, C17H13Cl2N3O2, CAS 477733-97-4
N-(2,3-Dichlorophenyl)-2-oxo-2-(2-(3-phenyl-2-propenylidene)hydrazino)acetamide
CAS 477733-97-4C17H13Cl2N3O2
N-(3-Methoxyphenyl)-2-oxo-2-(2-(3-phenyl-2-propenylidene)hydrazino)acetamide chemical structure, C18H17N3O3, CAS 765303-50-2
N-(3-Methoxyphenyl)-2-oxo-2-(2-(3-phenyl-2-propenylidene)hydrazino)acetamide
CAS 765303-50-2C18H17N3O3
N-(4-Ethylphenyl)-2-oxo-2-(2-(3-phenyl-2-propenylidene)hydrazino)acetamide chemical structure, C19H19N3O2, CAS 767312-37-8
N-(4-Ethylphenyl)-2-oxo-2-(2-(3-phenyl-2-propenylidene)hydrazino)acetamide
CAS 767312-37-8C19H19N3O2
2-Oxo-N-phenyl-2-(2-(3-phenyl-2-propenylidene)hydrazino)acetamide chemical structure, C17H15N3O2, CAS 53117-39-8
2-Oxo-N-phenyl-2-(2-(3-phenyl-2-propenylidene)hydrazino)acetamide
CAS 53117-39-8C17H15N3O2
N-(2-Methoxyphenyl)-2-oxo-2-(2-(3-phenyl-2-propenylidene)hydrazino)acetamide chemical structure, C18H17N3O3, CAS 477733-92-9
N-(2-Methoxyphenyl)-2-oxo-2-(2-(3-phenyl-2-propenylidene)hydrazino)acetamide
CAS 477733-92-9C18H17N3O3
N-(4-Methoxyphenyl)-2-oxo-2-(2-(3-phenyl-2-propenylidene)hydrazino)acetamide chemical structure, C18H17N3O3, CAS 765303-52-4
N-(4-Methoxyphenyl)-2-oxo-2-(2-(3-phenyl-2-propenylidene)hydrazino)acetamide
CAS 765303-52-4C18H17N3O3
N-(4-Methylphenyl)-2-(2-(2-ME-3-phenyl-2-propenylidene)hydrazino)-2-oxoacetamide chemical structure, C19H19N3O2, CAS 769152-39-8
N-(4-Methylphenyl)-2-(2-(2-ME-3-phenyl-2-propenylidene)hydrazino)-2-oxoacetamide
CAS 769152-39-8C19H19N3O2
2-(2-(2-Methyl-3-phenyl-2-propenylidene)hydrazino)-2-oxo-N-phenylacetamide chemical structure, C18H17N3O2, CAS 769149-54-4
2-(2-(2-Methyl-3-phenyl-2-propenylidene)hydrazino)-2-oxo-N-phenylacetamide
CAS 769149-54-4C18H17N3O2
N-(4-Ethylphenyl)-2-(2-(2-ME-3-phenyl-2-propenylidene)hydrazino)-2-oxoacetamide chemical structure, C20H21N3O2, CAS 769148-43-8
N-(4-Ethylphenyl)-2-(2-(2-ME-3-phenyl-2-propenylidene)hydrazino)-2-oxoacetamide
CAS 769148-43-8C20H21N3O2
N-(3,4-Dichlorophenyl)-2-{(2E)-2-[(2Z)-2-methyl-3-phenyl-2-propenylidene]hydrazino}-2-oxoacetamide chemical structure, C18H15Cl2N3O2, CAS 769147-84-4
N-(3,4-Dichlorophenyl)-2-{(2E)-2-[(2Z)-2-methyl-3-phenyl-2-propenylidene]hydrazino}-2-oxoacetamide
CAS 769147-84-4C18H15Cl2N3O2
N-(3-Methoxyphenyl)-2-(2-(2-ME-3-PH-2-propenylidene)hydrazino)-2-oxoacetamide chemical structure, C19H19N3O3, CAS 764655-59-6
N-(3-Methoxyphenyl)-2-(2-(2-ME-3-PH-2-propenylidene)hydrazino)-2-oxoacetamide
CAS 764655-59-6C19H19N3O3
N-(3-Meo-PH)-2-(2-(1-methyl-3-phenyl-2-propenylidene)hydrazino)-2-oxoacetamide chemical structure, C19H19N3O3, CAS 881462-60-8
N-(3-Meo-PH)-2-(2-(1-methyl-3-phenyl-2-propenylidene)hydrazino)-2-oxoacetamide
CAS 881462-60-8C19H19N3O3
N-(4-Meo-PH)-2-(2-(1-methyl-3-phenyl-2-propenylidene)hydrazino)-2-oxoacetamide chemical structure, C19H19N3O3, CAS 881461-34-3
N-(4-Meo-PH)-2-(2-(1-methyl-3-phenyl-2-propenylidene)hydrazino)-2-oxoacetamide
CAS 881461-34-3C19H19N3O3
N-(4-ME-PH)-2-(2-(1-Methyl-3-phenyl-2-propenylidene)hydrazino)-2-oxoacetamide chemical structure, C19H19N3O2, CAS 881453-47-0
N-(4-ME-PH)-2-(2-(1-Methyl-3-phenyl-2-propenylidene)hydrazino)-2-oxoacetamide
CAS 881453-47-0C19H19N3O2
N-(4-CL-PH)-2-(2-(2-Methyl-3-phenyl-2-propenylidene)hydrazino)-2-oxoacetamide chemical structure, C18H16ClN3O2, CAS 881403-00-5
N-(4-CL-PH)-2-(2-(2-Methyl-3-phenyl-2-propenylidene)hydrazino)-2-oxoacetamide
CAS 881403-00-5C18H16ClN3O2
N-(4-Ethoxy-PH)-2-(2-(2-methyl-3-PH-2-propenylidene)hydrazino)-2-oxoacetamide chemical structure, C20H21N3O3, CAS 881660-00-0
N-(4-Ethoxy-PH)-2-(2-(2-methyl-3-PH-2-propenylidene)hydrazino)-2-oxoacetamide
CAS 881660-00-0C20H21N3O3
N-(3-Chloro-2-methylphenyl)-2-(2-(2-methyl-3-phenyl-2-propenylidene)hydrazino)-2-oxoacetamide chemical structure, C19H18ClN3O2, CAS 881660-15-7
N-(3-Chloro-2-methylphenyl)-2-(2-(2-methyl-3-phenyl-2-propenylidene)hydrazino)-2-oxoacetamide
CAS 881660-15-7C19H18ClN3O2
N-(2-Methoxyphenyl)-2-(2-(2-ME-3-PH-2-propenylidene)hydrazino)-2-oxoacetamide chemical structure, C19H19N3O3, CAS 769148-14-3
N-(2-Methoxyphenyl)-2-(2-(2-ME-3-PH-2-propenylidene)hydrazino)-2-oxoacetamide
CAS 769148-14-3C19H19N3O3
N-(4-BR-Phenyl)-2-(2-(2-methyl-3-phenyl-2-propenylidene)hydrazino)-2-oxoacetamide chemical structure, C18H16BrN3O2, CAS 881466-79-1
N-(4-BR-Phenyl)-2-(2-(2-methyl-3-phenyl-2-propenylidene)hydrazino)-2-oxoacetamide
CAS 881466-79-1C18H16BrN3O2
N-(4-Methoxyphenyl)-2-(2-(2-ME-3-PH-2-propenylidene)hydrazino)-2-oxoacetamide chemical structure, C19H19N3O3, CAS 769157-06-4
N-(4-Methoxyphenyl)-2-(2-(2-ME-3-PH-2-propenylidene)hydrazino)-2-oxoacetamide
CAS 769157-06-4C19H19N3O3
N-(3-Methylphenyl)-2-(2-(2-ME-3-PH-2-propenylidene)hydrazino)-2-oxoacetamide chemical structure, C19H19N3O2, CAS 881664-68-2
N-(3-Methylphenyl)-2-(2-(2-ME-3-PH-2-propenylidene)hydrazino)-2-oxoacetamide
CAS 881664-68-2C19H19N3O2