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Murcko scaffold

Ring system with 5 rings and 29 atoms

10 chemicals on CompoundList share this ring system.

Rings
5
Scaffold atoms
29
Chemicals
10
With full pages
1
Scaffold SMILES

O=S(=O)(Nc1ccccc1)c1ccc2c(c1)C1C=CCC1C(c1ccccc1)N2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=S(=O)(Nc1ccccc1)c1ccc2c(c1)C1C=CCC1C(c1ccccc1)N2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 10 of 10 chemicals

Mdm2/xiap-IN-1 chemical structure, C28H28N2O4S, CAS 359595-95-2
Mdm2/xiap-IN-1
CAS 359595-95-2C28H28N2O4S
MX-69 chemical structure, C27H26N2O4S, CAS 1005264-47-0
MX-69
CAS 1005264-47-0C27H26N2O4S
N-(3,4-Dimethylphenyl)-4-(3-methoxyphenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide chemical structure, C27H28N2O3S, CAS 1243825-51-5
N-(3,4-Dimethylphenyl)-4-(3-methoxyphenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide
CAS 1243825-51-5C27H28N2O3S
N-(2,4-Dimethylphenyl)-4-(4-methoxyphenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide chemical structure, C27H28N2O3S, CAS 1243566-94-0
N-(2,4-Dimethylphenyl)-4-(4-methoxyphenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide
CAS 1243566-94-0C27H28N2O3S
4-(3-Methylphenyl)-N-phenyl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide chemical structure, C25H24N2O2S, CAS 486991-41-7
4-(3-Methylphenyl)-N-phenyl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide
CAS 486991-41-7C25H24N2O2S
N-(3,4-Dimethylphenyl)-4-(4-hydroxyphenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide chemical structure, C26H26N2O3S, CAS 1013790-64-1
N-(3,4-Dimethylphenyl)-4-(4-hydroxyphenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide
CAS 1013790-64-1C26H26N2O3S
3H-Cyclopenta[c]quinoline-8-sulfonamide, N-(3-chloro-4-methylphenyl)-3a,4,5,9b-tetrahydro-4-(4-methylphenyl)-, (3aR,4S,9bS)-rel- chemical structure, C26H25ClN2O2S, CAS 1217656-14-8
3H-Cyclopenta[c]quinoline-8-sulfonamide, N-(3-chloro-4-methylphenyl)-3a,4,5,9b-tetrahydro-4-(4-methylphenyl)-, (3aR,4S,9bS)-rel-
CAS 1217656-14-8C26H25ClN2O2S
rel-4-(((3aR,4S,9bS)-4-(4-Nitrophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline)-8-sulfonamido)benzoic acid chemical structure, C25H21N3O6S, CAS 1217641-06-9
rel-4-(((3aR,4S,9bS)-4-(4-Nitrophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline)-8-sulfonamido)benzoic acid
CAS 1217641-06-9C25H21N3O6S
rel-4-((3aR,4S,9bS)-8-(N-(4-Chloro-2-methylphenyl)sulfamoyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl)benzoic acid chemical structure, C26H23ClN2O4S, CAS 1217842-32-4
rel-4-((3aR,4S,9bS)-8-(N-(4-Chloro-2-methylphenyl)sulfamoyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl)benzoic acid
CAS 1217842-32-4C26H23ClN2O4S
N-(3,4-Dimethylphenyl)-4-(2-methoxyphenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide chemical structure, C27H28N2O3S, CAS 1243735-37-6
N-(3,4-Dimethylphenyl)-4-(2-methoxyphenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide
CAS 1243735-37-6C27H28N2O3S