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Murcko scaffold

Ring system with 4 rings and 23 atoms

14 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
23
Chemicals
14
With full pages
0
Scaffold SMILES

c1ccc(NC(c2ccccc2)c2c[nH]c3ccccc23)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(NC(c2ccccc2)c2c[nH]c3ccccc23)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 14 of 14 chemicals

Ethyl 4-{[(3,4-dimethoxyphenyl)(2-methyl-1H-indol-3-yl)methyl]amino}benzoate chemical structure, C27H28N2O4, CAS 526188-68-1
Ethyl 4-{[(3,4-dimethoxyphenyl)(2-methyl-1H-indol-3-yl)methyl]amino}benzoate
CAS 526188-68-1C27H28N2O4
N-((2-Methoxyphenyl)(2-methyl-1H-indol-3-yl)methyl)-3-(trifluoromethyl)aniline chemical structure, C24H21F3N2O, CAS 622799-35-3
N-((2-Methoxyphenyl)(2-methyl-1H-indol-3-yl)methyl)-3-(trifluoromethyl)aniline
CAS 622799-35-3C24H21F3N2O
N-[(2-Methoxyphenyl)-(2-methyl-1H-indol-3-yl)methyl]-2-(trifluoromethyl)aniline chemical structure, C24H21F3N2O, CAS 622799-66-0
N-[(2-Methoxyphenyl)-(2-methyl-1H-indol-3-yl)methyl]-2-(trifluoromethyl)aniline
CAS 622799-66-0C24H21F3N2O
N-[(1H-Indol-3-yl)(phenyl)methyl]-N-phenylacetamide chemical structure, C23H20N2O, CAS 51071-07-9
N-[(1H-Indol-3-yl)(phenyl)methyl]-N-phenylacetamide
CAS 51071-07-9C23H20N2O
N-((2-Chlorophenyl)(2-methyl-1H-indol-3-yl)methyl)-4-(trifluoromethyl)aniline chemical structure, C23H18ClF3N2, CAS 1378490-61-9
N-((2-Chlorophenyl)(2-methyl-1H-indol-3-yl)methyl)-4-(trifluoromethyl)aniline
CAS 1378490-61-9C23H18ClF3N2
N-(4-Ethoxyphenyl)-N-[(1H-indol-3-yl)(phenyl)methyl]acetamide chemical structure, C25H24N2O2, CAS 61123-64-6
N-(4-Ethoxyphenyl)-N-[(1H-indol-3-yl)(phenyl)methyl]acetamide
CAS 61123-64-6C25H24N2O2
N-(4-Bromophenyl)-N-[(1H-indol-3-yl)(phenyl)methyl]acetamide chemical structure, C23H19BrN2O, CAS 61123-59-9
N-(4-Bromophenyl)-N-[(1H-indol-3-yl)(phenyl)methyl]acetamide
CAS 61123-59-9C23H19BrN2O
N-[(1H-Indol-3-yl)(phenyl)methyl]-N-(4-nitrophenyl)acetamide chemical structure, C23H19N3O3, CAS 61123-54-4
N-[(1H-Indol-3-yl)(phenyl)methyl]-N-(4-nitrophenyl)acetamide
CAS 61123-54-4C23H19N3O3
N-[(1H-Indol-3-yl)(phenyl)methyl]-N-(4-methylphenyl)acetamide chemical structure, C24H22N2O, CAS 61123-49-7
N-[(1H-Indol-3-yl)(phenyl)methyl]-N-(4-methylphenyl)acetamide
CAS 61123-49-7C24H22N2O
Orb1702907 chemical structure, C24H21F3N2O, CAS 1529814-60-5
Orb1702907
CAS 1529814-60-5C24H21F3N2O
N-[(4-Methoxyphenyl)-(2-methyl-1H-indol-3-yl)methyl]-3-(trifluoromethyl)aniline chemical structure, C24H21F3N2O, CAS 537011-25-9
N-[(4-Methoxyphenyl)-(2-methyl-1H-indol-3-yl)methyl]-3-(trifluoromethyl)aniline
CAS 537011-25-9C24H21F3N2O
N-[(2-Methyl-1H-indol-3-yl)-(4-methylphenyl)methyl]-3-(trifluoromethyl)aniline chemical structure, C24H21F3N2, CAS 537011-37-3
N-[(2-Methyl-1H-indol-3-yl)-(4-methylphenyl)methyl]-3-(trifluoromethyl)aniline
CAS 537011-37-3C24H21F3N2
N-[(3,4-Dimethoxyphenyl)-(2-methyl-1H-indol-3-yl)methyl]-3-(trifluoromethyl)aniline chemical structure, C25H23F3N2O2, CAS 537011-50-0
N-[(3,4-Dimethoxyphenyl)-(2-methyl-1H-indol-3-yl)methyl]-3-(trifluoromethyl)aniline
CAS 537011-50-0C25H23F3N2O2
N-[(2-Methyl-1H-indol-3-yl)-(3,4,5-trimethoxyphenyl)methyl]-3-(trifluoromethyl)aniline chemical structure, C26H25F3N2O3, CAS 537011-77-1
N-[(2-Methyl-1H-indol-3-yl)-(3,4,5-trimethoxyphenyl)methyl]-3-(trifluoromethyl)aniline
CAS 537011-77-1C26H25F3N2O3