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Murcko scaffold

Ring system with 4 rings and 23 atoms

12 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
23
Chemicals
12
With full pages
4
Scaffold SMILES

c1ccc(N=C(c2ccccc2)c2c[nH]c3ccccc23)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(N=C(c2ccccc2)c2c[nH]c3ccccc23)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 12 of 12 chemicals

(Z)-3-(((3-((Dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxamide chemical structure, C25H24N4O2, CAS 1094614-84-2
(Z)-3-(((3-((Dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxamide
CAS 1094614-84-2C25H24N4O2
(Z)-3-(3-(((4-((Dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindolin-6-yl)-N-ethylpropiolamide chemical structure, C29H28N4O2, CAS 1207293-36-4
(Z)-3-(3-(((4-((Dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindolin-6-yl)-N-ethylpropiolamide
CAS 1207293-36-4C29H28N4O2
Methyl (3Z)-3-[[[3-[[[2-(dimethylamino)ethyl]methylamino]carbonyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indole-6-carboxylate chemical structure, C29H30N4O4, CAS 466694-60-0
Methyl (3Z)-3-[[[3-[[[2-(dimethylamino)ethyl]methylamino]carbonyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indole-6-carboxylate
CAS 466694-60-0C29H30N4O4
(Z)-3-((3-((Dimethylamino)methyl)phenylamino)(phenyl)methylene)-N,N-dimethyl-2-oxoindoline-6-carboxamide chemical structure, C27H28N4O2, CAS 1265916-41-3
(Z)-3-((3-((Dimethylamino)methyl)phenylamino)(phenyl)methylene)-N,N-dimethyl-2-oxoindoline-6-carboxamide
CAS 1265916-41-3C27H28N4O2
MEK inhibitor chemical structure, C26H26N4O2, CAS 334951-92-7
MEK inhibitor
CAS 334951-92-7C26H26N4O2
Nintedanib impurity N10 chemical structure, C23H17N3O5, CAS 1139457-10-5
Nintedanib impurity N10
CAS 1139457-10-5C23H17N3O5
Nintedanib acetyl impurity chemical structure, C26H23N3O4, CAS 1139458-48-2
Nintedanib acetyl impurity
CAS 1139458-48-2C26H23N3O4
(Z)-3-(((4-((Dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-6-iodoindolin-2-one chemical structure, C24H22IN3O, CAS 1537909-08-2
(Z)-3-(((4-((Dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-6-iodoindolin-2-one
CAS 1537909-08-2C24H22IN3O
(Z)-Methyl 3-(((4-(methylamino)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate (Nintedanib Impurity) chemical structure, C24H21N3O3, CAS 1987887-92-2
(Z)-Methyl 3-(((4-(methylamino)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate (Nintedanib Impurity)
CAS 1987887-92-2C24H21N3O3
Methyl (Z)-3-(((4-(2-chloro-N-methylacetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate chemical structure, C26H22ClN3O4, CAS 1987887-93-3
Methyl (Z)-3-(((4-(2-chloro-N-methylacetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
CAS 1987887-93-3C26H22ClN3O4
N-tert-Butyloxycarbonyl N-Methyl Nintedanib chemical structure, C29H29N3O5, CAS 1987887-91-1
N-tert-Butyloxycarbonyl N-Methyl Nintedanib
CAS 1987887-91-1C29H29N3O5
(Z)-Methyl 3-(((4-hydroxyphenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate chemical structure, C23H18N2O4, CAS 2519501-85-8
(Z)-Methyl 3-(((4-hydroxyphenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
CAS 2519501-85-8C23H18N2O4