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Murcko scaffold

Ring system with 4 rings and 22 atoms

38 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
22
Chemicals
38
With full pages
4
Scaffold SMILES

O=C1CN2C(SCc3ccccc3)=Nc3ccccc3C2=N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1CN2C(SCc3ccccc3)=Nc3ccccc3C2=N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 38 of 38 chemicals

5-[(3-Chlorobenzyl)sulfanyl]imidazo[1,2-c]quinazolin-2(3H)-one chemical structure, C17H12ClN3OS, CAS 477889-49-9
5-[(3-Chlorobenzyl)sulfanyl]imidazo[1,2-c]quinazolin-2(3H)-one
CAS 477889-49-9C17H12ClN3OS
5-[(4-Bromobenzyl)sulfanyl]imidazo[1,2-c]quinazolin-2(3H)-one chemical structure, C17H12BrN3OS, CAS 478046-05-8
5-[(4-Bromobenzyl)sulfanyl]imidazo[1,2-c]quinazolin-2(3H)-one
CAS 478046-05-8C17H12BrN3OS
5-[(2-Methylbenzyl)sulfanyl]imidazo[1,2-c]quinazolin-2(3H)-one chemical structure, C18H15N3OS, CAS 478046-11-6
5-[(2-Methylbenzyl)sulfanyl]imidazo[1,2-c]quinazolin-2(3H)-one
CAS 478046-11-6C18H15N3OS
5-{[4-(Trifluoromethyl)benzyl]sulfanyl}imidazo[1,2-c]quinazolin-2(3H)-one chemical structure, C18H12F3N3OS, CAS 478046-12-7
5-{[4-(Trifluoromethyl)benzyl]sulfanyl}imidazo[1,2-c]quinazolin-2(3H)-one
CAS 478046-12-7C18H12F3N3OS
5-[(3-Fluorobenzyl)sulfanyl]imidazo[1,2-c]quinazolin-2(3H)-one chemical structure, C17H12FN3OS, CAS 478046-13-8
5-[(3-Fluorobenzyl)sulfanyl]imidazo[1,2-c]quinazolin-2(3H)-one
CAS 478046-13-8C17H12FN3OS
5-[(2-Chloro-6-fluorobenzyl)sulfanyl]imidazo[1,2-c]quinazolin-2(3H)-one chemical structure, C17H11ClFN3OS, CAS 478046-17-2
5-[(2-Chloro-6-fluorobenzyl)sulfanyl]imidazo[1,2-c]quinazolin-2(3H)-one
CAS 478046-17-2C17H11ClFN3OS
5-[(2,4-Dichlorobenzyl)sulfanyl]imidazo[1,2-c]quinazolin-2(3H)-one chemical structure, C17H11Cl2N3OS, CAS 478046-18-3
5-[(2,4-Dichlorobenzyl)sulfanyl]imidazo[1,2-c]quinazolin-2(3H)-one
CAS 478046-18-3C17H11Cl2N3OS
5-[(4-Ethylbenzyl)sulfanyl]imidazo[1,2-c]quinazolin-2(3H)-one chemical structure, C19H17N3OS, CAS 439108-22-2
5-[(4-Ethylbenzyl)sulfanyl]imidazo[1,2-c]quinazolin-2(3H)-one
CAS 439108-22-2C19H17N3OS
5-[(2-Fluorobenzyl)sulfanyl]imidazo[1,2-c]quinazolin-2(3H)-one chemical structure, C17H12FN3OS, CAS 439108-27-7
5-[(2-Fluorobenzyl)sulfanyl]imidazo[1,2-c]quinazolin-2(3H)-one
CAS 439108-27-7C17H12FN3OS
5-[(4-Methylbenzyl)sulfanyl]imidazo[1,2-c]quinazolin-2(3H)-one chemical structure, C18H15N3OS, CAS 478046-22-9
5-[(4-Methylbenzyl)sulfanyl]imidazo[1,2-c]quinazolin-2(3H)-one
CAS 478046-22-9C18H15N3OS
5-{[3,5-Bis(trifluoromethyl)benzyl]sulfanyl}-8,9-dimethoxyimidazo[1,2-c]quinazolin-2(3H)-one chemical structure, C21H15F6N3O3S, CAS 439109-35-0
5-{[3,5-Bis(trifluoromethyl)benzyl]sulfanyl}-8,9-dimethoxyimidazo[1,2-c]quinazolin-2(3H)-one
CAS 439109-35-0C21H15F6N3O3S
5-[(2-Chloro-6-fluorobenzyl)sulfanyl]-8,9-dimethoxyimidazo[1,2-c]quinazolin-2(3H)-one chemical structure, C19H15ClFN3O3S, CAS 672949-33-6
5-[(2-Chloro-6-fluorobenzyl)sulfanyl]-8,9-dimethoxyimidazo[1,2-c]quinazolin-2(3H)-one
CAS 672949-33-6C19H15ClFN3O3S
5-[(2,6-Dichlorobenzyl)sulfanyl]-8,9-dimethoxyimidazo[1,2-c]quinazolin-2(3H)-one chemical structure, C19H15Cl2N3O3S, CAS 439109-49-6
5-[(2,6-Dichlorobenzyl)sulfanyl]-8,9-dimethoxyimidazo[1,2-c]quinazolin-2(3H)-one
CAS 439109-49-6C19H15Cl2N3O3S
5-[(3,4-Dichlorobenzyl)sulfanyl]-8,9-dimethoxyimidazo[1,2-c]quinazolin-2(3H)-one chemical structure, C19H15Cl2N3O3S, CAS 672949-19-8
5-[(3,4-Dichlorobenzyl)sulfanyl]-8,9-dimethoxyimidazo[1,2-c]quinazolin-2(3H)-one
CAS 672949-19-8C19H15Cl2N3O3S
5-[(3,4-Dichlorobenzyl)sulfanyl]-3-isopropyl-8,9-dimethoxyimidazo[1,2-c]quinazolin-2(3H)-one chemical structure, C22H21Cl2N3O3S, CAS 1023939-04-9
5-[(3,4-Dichlorobenzyl)sulfanyl]-3-isopropyl-8,9-dimethoxyimidazo[1,2-c]quinazolin-2(3H)-one
CAS 1023939-04-9C22H21Cl2N3O3S
5-[(3-Chlorobenzyl)sulfanyl]-8,9-dimethoxyimidazo[1,2-c]quinazolin-2(3H)-one chemical structure, C19H16ClN3O3S, CAS 439109-15-6
5-[(3-Chlorobenzyl)sulfanyl]-8,9-dimethoxyimidazo[1,2-c]quinazolin-2(3H)-one
CAS 439109-15-6C19H16ClN3O3S
3-Isopropyl-8,9-dimethoxy-5-[(2-methylbenzyl)sulfanyl]imidazo[1,2-c]quinazolin-2(3H)-one chemical structure, C23H25N3O3S, CAS 920529-89-1
3-Isopropyl-8,9-dimethoxy-5-[(2-methylbenzyl)sulfanyl]imidazo[1,2-c]quinazolin-2(3H)-one
CAS 920529-89-1C23H25N3O3S
8,9-Dimethoxy-5-[(4-methylbenzyl)sulfanyl]imidazo[1,2-c]quinazolin-2(3H)-one chemical structure, C20H19N3O3S, CAS 672949-21-2
8,9-Dimethoxy-5-[(4-methylbenzyl)sulfanyl]imidazo[1,2-c]quinazolin-2(3H)-one
CAS 672949-21-2C20H19N3O3S
8,9-Dimethoxy-5-[(3-methylbenzyl)sulfanyl]imidazo[1,2-c]quinazolin-2(3H)-one chemical structure, C20H19N3O3S, CAS 672949-25-6
8,9-Dimethoxy-5-[(3-methylbenzyl)sulfanyl]imidazo[1,2-c]quinazolin-2(3H)-one
CAS 672949-25-6C20H19N3O3S
3-Isopropyl-8,9-dimethoxy-5-{[2-(trifluoromethyl)benzyl]sulfanyl}imidazo[1,2-c]quinazolin-2(3H)-one chemical structure, C23H22F3N3O3S, CAS 1030881-50-5
3-Isopropyl-8,9-dimethoxy-5-{[2-(trifluoromethyl)benzyl]sulfanyl}imidazo[1,2-c]quinazolin-2(3H)-one
CAS 1030881-50-5C23H22F3N3O3S
5-[(4-Fluorobenzyl)sulfanyl]-3-isopropyl-8,9-dimethoxyimidazo[1,2-c]quinazolin-2(3H)-one chemical structure, C22H22FN3O3S, CAS 1030938-55-6
5-[(4-Fluorobenzyl)sulfanyl]-3-isopropyl-8,9-dimethoxyimidazo[1,2-c]quinazolin-2(3H)-one
CAS 1030938-55-6C22H22FN3O3S
5-[(3-Fluorobenzyl)sulfanyl]-3-isopropyl-8,9-dimethoxyimidazo[1,2-c]quinazolin-2(3H)-one chemical structure, C22H22FN3O3S, CAS 1214102-54-1
5-[(3-Fluorobenzyl)sulfanyl]-3-isopropyl-8,9-dimethoxyimidazo[1,2-c]quinazolin-2(3H)-one
CAS 1214102-54-1C22H22FN3O3S
5-[(2-Chloro-6-fluorobenzyl)sulfanyl]-3-isopropyl-8,9-dimethoxyimidazo[1,2-c]quinazolin-2(3H)-one chemical structure, C22H21ClFN3O3S, CAS 1024594-03-3
5-[(2-Chloro-6-fluorobenzyl)sulfanyl]-3-isopropyl-8,9-dimethoxyimidazo[1,2-c]quinazolin-2(3H)-one
CAS 1024594-03-3C22H21ClFN3O3S
3-Isopropyl-8,9-dimethoxy-5-[(4-methoxybenzyl)sulfanyl]imidazo[1,2-c]quinazolin-2(3H)-one chemical structure, C23H25N3O4S, CAS 1024594-16-8
3-Isopropyl-8,9-dimethoxy-5-[(4-methoxybenzyl)sulfanyl]imidazo[1,2-c]quinazolin-2(3H)-one
CAS 1024594-16-8C23H25N3O4S