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Murcko scaffold

Ring system with 3 rings and 21 atoms

9 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
9
With full pages
5
Scaffold SMILES

O=C(CN1C(=O)NC2(CCCC2)C1=O)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CN1C(=O)NC2(CCCC2)C1=O)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 9 of 9 chemicals

N-(2-tert-Butylphenyl)-2-(2,4-dioxo-1,3-diazaspiro[4.4]nonan-3-yl)acetamide chemical structure, C19H25N3O3, CAS 743470-69-1
N-(2-tert-Butylphenyl)-2-(2,4-dioxo-1,3-diazaspiro[4.4]nonan-3-yl)acetamide
CAS 743470-69-1C19H25N3O3
N-(2,4-Dimethoxyphenyl)-2-{2,4-dioxo-1,3-diazaspiro[4.4]nonan-3-yl}acetamide chemical structure, C17H21N3O5, CAS 731775-47-6
N-(2,4-Dimethoxyphenyl)-2-{2,4-dioxo-1,3-diazaspiro[4.4]nonan-3-yl}acetamide
CAS 731775-47-6C17H21N3O5
2-(2,4-Dioxo-1,3-diazaspiro[4.4]nonan-3-yl)-N-(4-methoxyphenyl)acetamide chemical structure, C16H19N3O4, CAS 797009-72-4
2-(2,4-Dioxo-1,3-diazaspiro[4.4]nonan-3-yl)-N-(4-methoxyphenyl)acetamide
CAS 797009-72-4C16H19N3O4
N-(3-Chloro-4-methylphenyl)-2-{2,4-dioxo-1,3-diazaspiro[4.4]nonan-3-yl}acetamide chemical structure, C16H18ClN3O3, CAS 930982-15-3
N-(3-Chloro-4-methylphenyl)-2-{2,4-dioxo-1,3-diazaspiro[4.4]nonan-3-yl}acetamide
CAS 930982-15-3C16H18ClN3O3
N-(4-Chloro-2-fluorophenyl)-2-(2,4-dioxo-1,3-diazaspiro[4.4]nonan-3-yl)acetamide chemical structure, C15H15ClFN3O3, CAS 853323-52-1
N-(4-Chloro-2-fluorophenyl)-2-(2,4-dioxo-1,3-diazaspiro[4.4]nonan-3-yl)acetamide
CAS 853323-52-1C15H15ClFN3O3
N-(3-Chloro-4-cyanophenyl)-2-(2,4-dioxo-1,3-diazaspiro[4.4]nonan-3-yl)acetamide chemical structure, C16H15ClN4O3, CAS 801275-30-9
N-(3-Chloro-4-cyanophenyl)-2-(2,4-dioxo-1,3-diazaspiro[4.4]nonan-3-yl)acetamide
CAS 801275-30-9C16H15ClN4O3
N-(4-Chloro-2,5-dimethoxyphenyl)-2-(2,4-dioxo-1,3-diazaspiro[4.4]nonan-3-yl)acetamide chemical structure, C17H20ClN3O5, CAS 853696-42-1
N-(4-Chloro-2,5-dimethoxyphenyl)-2-(2,4-dioxo-1,3-diazaspiro[4.4]nonan-3-yl)acetamide
CAS 853696-42-1C17H20ClN3O5
Methyl 4-{[(2,4-dioxo-1,3-diazaspiro[4.4]non-3-yl)acetyl]amino}benzoate chemical structure, C17H19N3O5, CAS 923235-78-3
Methyl 4-{[(2,4-dioxo-1,3-diazaspiro[4.4]non-3-yl)acetyl]amino}benzoate
CAS 923235-78-3C17H19N3O5
2-(2,4-Dioxo-1,3-diazaspiro[4.4]non-3-yl)-N-(3,4,5-trifluorophenyl)acetamide chemical structure, C15H14F3N3O3, CAS 1324082-43-0
2-(2,4-Dioxo-1,3-diazaspiro[4.4]non-3-yl)-N-(3,4,5-trifluorophenyl)acetamide
CAS 1324082-43-0C15H14F3N3O3