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Murcko scaffold

5,8-Isoquinolinedione scaffold

23 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
12
Chemicals
23
With full pages
6
Scaffold SMILES

O=C1C=CC(=O)c2cnccc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 5,8-Isoquinolinedione page
Murcko scaffold O=C1C=CC(=O)c2cnccc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 23 of 23 chemicals

Caulibugulone A chemical structure, C10H8N2O2, CAS 662167-15-9
Caulibugulone A
CAS 662167-15-9C10H8N2O2
Caulibugulone B chemical structure, C10H7BrN2O2, CAS 662167-16-0
Caulibugulone B
CAS 662167-16-0C10H7BrN2O2
Caulibugulone C chemical structure, C10H7ClN2O2, CAS 662167-17-1
Caulibugulone C
CAS 662167-17-1C10H7ClN2O2
Caulibugulone D chemical structure, C11H10N2O3, CAS 662167-18-2
Caulibugulone D
CAS 662167-18-2C11H10N2O3
5,8-Isoquinolinedione chemical structure, C9H5NO2, CAS 50-46-4
5,8-Isoquinolinedione
CAS 50-46-4C9H5NO2
7-Methoxy-1,6-dimethyl-5,8-dihydroisoquinoline-5,8-dione chemical structure, C12H11NO3, CAS 79664-58-7
7-Methoxy-1,6-dimethyl-5,8-dihydroisoquinoline-5,8-dione
CAS 79664-58-7C12H11NO3
5,8-Isoquinolinedione, 6,7-dichloro- chemical structure, C9H3Cl2NO2, CAS 84289-03-2
5,8-Isoquinolinedione, 6,7-dichloro-
CAS 84289-03-2C9H3Cl2NO2
3-Methylisoquinoline-5,8-dione chemical structure, C10H7NO2, CAS 24011-03-8
3-Methylisoquinoline-5,8-dione
CAS 24011-03-8C10H7NO2
7-Methoxyisoquinoline-5,8-dione chemical structure, C10H7NO3, CAS 24011-04-9
7-Methoxyisoquinoline-5,8-dione
CAS 24011-04-9C10H7NO3
7-Methoxy-6-methylisoquinoline-5,8-dione chemical structure, C11H9NO3, CAS 76177-29-2
7-Methoxy-6-methylisoquinoline-5,8-dione
CAS 76177-29-2C11H9NO3
1-Cyano-7-methoxy-6-methyl-5,8-dihydroisoquinoline-5,8-dione chemical structure, C12H8N2O3, CAS 86433-72-9
1-Cyano-7-methoxy-6-methyl-5,8-dihydroisoquinoline-5,8-dione
CAS 86433-72-9C12H8N2O3
1-Cyano-7-ethoxy-5,8-dihydroisoquinoline-5,8-dione chemical structure, C12H8N2O3, CAS 113361-37-8
1-Cyano-7-ethoxy-5,8-dihydroisoquinoline-5,8-dione
CAS 113361-37-8C12H8N2O3
7-Butyloxy-1-cyano-5,8-dihydroisoquinoline-5,8-dione chemical structure, C14H12N2O3, CAS 113387-45-4
7-Butyloxy-1-cyano-5,8-dihydroisoquinoline-5,8-dione
CAS 113387-45-4C14H12N2O3
Renierol chemical structure, C12H11NO4, CAS 16795-96-3
Renierol
CAS 16795-96-3C12H11NO4
Mimocine chemical structure, C15H14N2O5, CAS 76177-28-1
Mimocine
CAS 76177-28-1C15H14N2O5
Cribrostatin 3 chemical structure, C16H16N2O4, CAS 276682-84-9
Cribrostatin 3
CAS 276682-84-9C16H16N2O4
Renierone chemical structure, C17H17NO5, CAS 73777-65-8
Renierone
CAS 73777-65-8C17H17NO5
7-Aminoisoquinoline-5,8-dione chemical structure, C9H6N2O2, CAS 118680-81-2
7-Aminoisoquinoline-5,8-dione
CAS 118680-81-2C9H6N2O2
Mansouramycin A chemical structure, C12H12N2O2, CAS 1199808-44-0
Mansouramycin A
CAS 1199808-44-0C12H12N2O2
Mansouramycin B chemical structure, C11H9ClN2O2, CAS 1199808-45-1
Mansouramycin B
CAS 1199808-45-1C11H9ClN2O2
Mansouramycin C chemical structure, C12H10N2O4, CAS 1199808-46-2
Mansouramycin C
CAS 1199808-46-2C12H10N2O4
6-[(2-Hydroxyethyl)amino]-5,8-isoquinolinedione chemical structure, C11H10N2O3, CAS 761429-85-0
6-[(2-Hydroxyethyl)amino]-5,8-isoquinolinedione
CAS 761429-85-0C11H10N2O3
7-Amino-6-chloroisoquinoline-5,8-dione chemical structure, C9H5ClN2O2, CAS 192630-52-7
7-Amino-6-chloroisoquinoline-5,8-dione
CAS 192630-52-7C9H5ClN2O2