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Murcko scaffold

Isoquinoline scaffold

5,396 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
10
Chemicals
5,396
With full pages
569
Scaffold SMILES

c1ccc2cnccc2c1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the Isoquinoline page
Murcko scaffold c1ccc2cnccc2c1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 5,396 chemicals

4-Cyano-3-methylisoquinoline chemical structure, C11H8N2, CAS 161468-32-2
4-Cyano-3-methylisoquinoline
CAS 161468-32-2C11H8N2
N-(2-(Methylamino)ethyl)-5-isoquinolinesulfonamide chemical structure, C12H15N3O2S, CAS 84478-11-5
N-(2-(Methylamino)ethyl)-5-isoquinolinesulfonamide
CAS 84478-11-5C12H15N3O2S
N-(2-Aminoethyl)isoquinoline-5-sulfonamide chemical structure, C11H13N3O2S, CAS 84468-17-7
N-(2-Aminoethyl)isoquinoline-5-sulfonamide
CAS 84468-17-7C11H13N3O2S
N-(2-((Aminoiminomethyl)amino)ethyl)-5-isoquinolinesulfonamide chemical structure, C12H15N5O2S, CAS 91742-10-8
N-(2-((Aminoiminomethyl)amino)ethyl)-5-isoquinolinesulfonamide
CAS 91742-10-8C12H15N5O2S
Quinisocaine chemical structure, C17H24N2O, CAS 86-80-6
Quinisocaine
CAS 86-80-6C17H24N2O
Lauryl isoquinolinium chemical structure, C21H32N+, CAS 16826-19-0
Lauryl isoquinolinium
CAS 16826-19-0C21H32N+
Isoquinoline chemical structure, C9H7N, CAS 119-65-3
Isoquinoline
CAS 119-65-3C9H7N
3-Methylisoquinoline chemical structure, C10H9N, CAS 1125-80-0
3-Methylisoquinoline
CAS 1125-80-0C10H9N
1-Methylisoquinoline chemical structure, C10H9N, CAS 1721-93-3
1-Methylisoquinoline
CAS 1721-93-3C10H9N
4-Isoquinolinol chemical structure, C9H7NO, CAS 3336-49-0
4-Isoquinolinol
CAS 3336-49-0C9H7NO
N-Methylisoquinolinium chemical structure, C10H10N+, CAS 33718-23-9
N-Methylisoquinolinium
CAS 33718-23-9C10H10N+
6,7-Dimethoxy-1-methylisoquinoline chemical structure, C12H13NO2, CAS 4594-02-9
6,7-Dimethoxy-1-methylisoquinoline
CAS 4594-02-9C12H13NO2
Isoquinolin-5-ol chemical structure, C9H7NO, CAS 2439-04-5
Isoquinolin-5-ol
CAS 2439-04-5C9H7NO
Methyl 2-(isoquinolin-1-yl)acetate chemical structure, C12H11NO2, CAS 69582-93-0
Methyl 2-(isoquinolin-1-yl)acetate
CAS 69582-93-0C12H11NO2
3-Isoquinolinecarboxamide, N-(2-(dimethylamino)ethyl)-1-methoxy-4-methyl- chemical structure, C16H21N3O2, CAS 89928-85-8
3-Isoquinolinecarboxamide, N-(2-(dimethylamino)ethyl)-1-methoxy-4-methyl-
CAS 89928-85-8C16H21N3O2
3-Isoquinolinecarboxamide, 1-chloro-N-(2-(dimethylamino)ethyl)-4-methyl- chemical structure, C15H18ClN3O, CAS 89928-93-8
3-Isoquinolinecarboxamide, 1-chloro-N-(2-(dimethylamino)ethyl)-4-methyl-
CAS 89928-93-8C15H18ClN3O
5-Dimethylaminomethyleneaminoisoquinoline chemical structure, C12H13N3, CAS 101398-66-7
5-Dimethylaminomethyleneaminoisoquinoline
CAS 101398-66-7C12H13N3
Isoquinoline-1-carboxylic acid chemical structure, C10H7NO2, CAS 486-73-7
Isoquinoline-1-carboxylic acid
CAS 486-73-7C10H7NO2
5-Nitroisoquinoline chemical structure, C9H6N2O2, CAS 607-32-9
5-Nitroisoquinoline
CAS 607-32-9C9H6N2O2
5-Aminoisoquinoline chemical structure, C9H8N2, CAS 1125-60-6
5-Aminoisoquinoline
CAS 1125-60-6C9H8N2
1-Isoquinolinamine chemical structure, C9H8N2, CAS 1532-84-9
1-Isoquinolinamine
CAS 1532-84-9C9H8N2
4-Bromoisoquinoline chemical structure, C9H6BrN, CAS 1532-97-4
4-Bromoisoquinoline
CAS 1532-97-4C9H6BrN
1,3-Dimethylisoquinoline chemical structure, C11H11N, CAS 1721-94-4
1,3-Dimethylisoquinoline
CAS 1721-94-4C11H11N
Isoquinolinium, 2-(3-sulfopropyl)-, inner salt chemical structure, C12H13NO3S, CAS 15589-64-7
Isoquinolinium, 2-(3-sulfopropyl)-, inner salt
CAS 15589-64-7C12H13NO3S