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Murcko scaffold

1,2,3,4-Tetrahydroisoquinoline scaffold

5,027 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
10
Chemicals
5,027
With full pages
607
Scaffold SMILES

c1ccc2c(c1)CCNC2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1,2,3,4-Tetrahydroisoquinoline page
Murcko scaffold c1ccc2c(c1)CCNC2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 5,027 chemicals

Debrisoquine chemical structure, C10H13N3, CAS 1131-64-2
Debrisoquine
CAS 1131-64-2C10H13N3
1,2,3,4-Tetrahydroisoquinoline-7-sulfonamide chemical structure, C9H12N2O2S, CAS 31404-61-2
1,2,3,4-Tetrahydroisoquinoline-7-sulfonamide
CAS 31404-61-2C9H12N2O2S
1,2,3,4-Tetrahydroisoquinoline chemical structure, C9H11N, CAS 91-21-4
1,2,3,4-Tetrahydroisoquinoline
CAS 91-21-4C9H11N
6,7-Dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline chemical structure, C12H17NO2, CAS 5784-74-7
6,7-Dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline
CAS 5784-74-7C12H17NO2
2-Methyl-1,2,3,4-tetrahydroisoquinoline chemical structure, C10H13N, CAS 1612-65-3
2-Methyl-1,2,3,4-tetrahydroisoquinoline
CAS 1612-65-3C10H13N
6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline chemical structure, C11H15NO2, CAS 1745-07-9
6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline
CAS 1745-07-9C11H15NO2
2-Ethyl-1,2,3,4-tetrahydro-5-isoquinolinol chemical structure, C11H15NO, CAS 16232-60-3
2-Ethyl-1,2,3,4-tetrahydro-5-isoquinolinol
CAS 16232-60-3C11H15NO
2-Amino-1,2,3,4-tetrahydroisoquinoline chemical structure, C9H12N2, CAS 4836-98-0
2-Amino-1,2,3,4-tetrahydroisoquinoline
CAS 4836-98-0C9H12N2
6,7-Dimethoxy-3-methyl-1,2,3,4-tetrahydroisoquinoline chemical structure, C12H17NO2, CAS 249624-84-8
6,7-Dimethoxy-3-methyl-1,2,3,4-tetrahydroisoquinoline
CAS 249624-84-8C12H17NO2
Carnegine chemical structure, C13H19NO2, CAS 490-53-9
Carnegine
CAS 490-53-9C13H19NO2
1,2,3,4-Tetrahydro-6,7-dimethoxy-2,3-dimethylisoquinoline chemical structure, C13H19NO2, CAS 5884-23-1
1,2,3,4-Tetrahydro-6,7-dimethoxy-2,3-dimethylisoquinoline
CAS 5884-23-1C13H19NO2
Malononitrile, ((3,4-dihydro-2(1H)-isoquinolyl)methylene)- chemical structure, C13H11N3, CAS 6687-82-7
Malononitrile, ((3,4-dihydro-2(1H)-isoquinolyl)methylene)-
CAS 6687-82-7C13H11N3
6-Isoquinolinol, 1,2,3,4-tetrahydro-2-methyl- chemical structure, C10H13NO, CAS 14097-39-3
6-Isoquinolinol, 1,2,3,4-tetrahydro-2-methyl-
CAS 14097-39-3C10H13NO
1,2,3,4-Tetrahydroisoquinolin-6-ol chemical structure, C9H11NO, CAS 14446-24-3
1,2,3,4-Tetrahydroisoquinolin-6-ol
CAS 14446-24-3C9H11NO
6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquinoline chemical structure, C12H17NO2, CAS 16620-96-5
6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquinoline
CAS 16620-96-5C12H17NO2
2-Ethyl-1,2,3,4-tetrahydroisoquinolin-5-yl acetate chemical structure, C13H17NO2, CAS 16232-63-6
2-Ethyl-1,2,3,4-tetrahydroisoquinolin-5-yl acetate
CAS 16232-63-6C13H17NO2
8-Methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline chemical structure, C11H15NO, CAS 73903-30-7
8-Methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline
CAS 73903-30-7C11H15NO
2-(3-(Ethylsulfinyl)propyl)-1,2,3,4-tetrahydroisoquinoline chemical structure, C14H21NOS, CAS 37517-33-2
2-(3-(Ethylsulfinyl)propyl)-1,2,3,4-tetrahydroisoquinoline
CAS 37517-33-2C14H21NOS
1-Isoquinolinecarboxylic acid, 1,2,3,4-tetrahydro-4,6-dihydroxy-2-methyl-, methyl ester chemical structure, C12H15NO4, CAS 23824-12-6
1-Isoquinolinecarboxylic acid, 1,2,3,4-tetrahydro-4,6-dihydroxy-2-methyl-, methyl ester
CAS 23824-12-6C12H15NO4
1-Isoquinolinecarboxylic acid, 1,2,3,4-tetrahydro-4,6-dihydroxy-2-methyl-, isopentyl ester chemical structure, C16H23NO4, CAS 23824-29-5
1-Isoquinolinecarboxylic acid, 1,2,3,4-tetrahydro-4,6-dihydroxy-2-methyl-, isopentyl ester
CAS 23824-29-5C16H23NO4
1-Isoquinolinecarboxylic acid, 1,2,3,4-tetrahydro-4,6-dihydroxy-, ethyl ester chemical structure, C12H15NO4, CAS 23824-30-8
1-Isoquinolinecarboxylic acid, 1,2,3,4-tetrahydro-4,6-dihydroxy-, ethyl ester
CAS 23824-30-8C12H15NO4
1-Isoquinolinecarboxylic acid, 1,2,3,4-tetrahydro-4,6-dihydroxy-, isobutyl ester chemical structure, C14H19NO4, CAS 23824-33-1
1-Isoquinolinecarboxylic acid, 1,2,3,4-tetrahydro-4,6-dihydroxy-, isobutyl ester
CAS 23824-33-1C14H19NO4
2-(2-Chloroethyl)-3,4-dihydro-1H-isoquinoline chemical structure, C11H14ClN, CAS 68085-34-7
2-(2-Chloroethyl)-3,4-dihydro-1H-isoquinoline
CAS 68085-34-7C11H14ClN
Acetamide, N-(1,2,3,4-tetrahydro-2-methylisoquinolin-5-yl)- chemical structure, C12H16N2O, CAS 27536-05-6
Acetamide, N-(1,2,3,4-tetrahydro-2-methylisoquinolin-5-yl)-
CAS 27536-05-6C12H16N2O