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Murcko scaffold

Ring system with 3 rings and 18 atoms

8 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
8
With full pages
7
Scaffold SMILES

O=C1NC2=C(C(=O)CCC2)C(c2ccccc2)N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1NC2=C(C(=O)CCC2)C(c2ccccc2)N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 8 of 8 chemicals

1-Methyl-4-(3,4,5-trimethoxyphenyl)-4,6,7,8-tetrahydro-3H-quinazoline-2,5-dione chemical structure, C18H22N2O5, CAS 385407-45-4
1-Methyl-4-(3,4,5-trimethoxyphenyl)-4,6,7,8-tetrahydro-3H-quinazoline-2,5-dione
CAS 385407-45-4C18H22N2O5
1-Methyl-4-(2-nitrophenyl)-4,6,7,8-tetrahydro-3H-quinazoline-2,5-dione chemical structure, C15H15N3O4, CAS 433250-37-4
1-Methyl-4-(2-nitrophenyl)-4,6,7,8-tetrahydro-3H-quinazoline-2,5-dione
CAS 433250-37-4C15H15N3O4
2,5(1H,3H)-Quinazolinedione, 4-(2-chlorophenyl)-4,6,7,8-tetrahydro- chemical structure, C14H13ClN2O2, CAS 107775-56-4
2,5(1H,3H)-Quinazolinedione, 4-(2-chlorophenyl)-4,6,7,8-tetrahydro-
CAS 107775-56-4C14H13ClN2O2
4-(3-Nitrophenyl)-3,4,7,8-tetrahydroquinazoline-2,5(1H,6H)-dione chemical structure, C14H13N3O4, CAS 204516-58-5
4-(3-Nitrophenyl)-3,4,7,8-tetrahydroquinazoline-2,5(1H,6H)-dione
CAS 204516-58-5C14H13N3O4
7,7-Dimethyl-4-phenyl-3,4,6,8-tetrahydro-1H-quinazoline-2,5-dione chemical structure, C16H18N2O2, CAS 367907-86-6
7,7-Dimethyl-4-phenyl-3,4,6,8-tetrahydro-1H-quinazoline-2,5-dione
CAS 367907-86-6C16H18N2O2
4-(4-Chlorophenyl)-7,7-dimethyl-3,4,6,8-tetrahydro-1H-quinazoline-2,5-dione chemical structure, C16H17ClN2O2, CAS 303786-34-7
4-(4-Chlorophenyl)-7,7-dimethyl-3,4,6,8-tetrahydro-1H-quinazoline-2,5-dione
CAS 303786-34-7C16H17ClN2O2
RefChem:314057 chemical structure, C15H16N2O2, CAS 204516-54-1
RefChem:314057
CAS 204516-54-1C15H16N2O2
4-[4-(Difluoromethoxy)phenyl]-1,3,4,6,7,8-hexahydroquinazoline-2,5-dione chemical structure, C15H14F2N2O3, CAS 300850-23-1
4-[4-(Difluoromethoxy)phenyl]-1,3,4,6,7,8-hexahydroquinazoline-2,5-dione
CAS 300850-23-1C15H14F2N2O3