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Murcko scaffold

4-Phenyl-1-(2H)-phthalazinone scaffold

148 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
17
Chemicals
148
With full pages
72
Scaffold SMILES

O=c1[nH]nc(-c2ccccc2)c2ccccc12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 4-Phenyl-1-(2H)-phthalazinone page
Murcko scaffold O=c1[nH]nc(-c2ccccc2)c2ccccc12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 148 chemicals

4-Phenyl-1-(2H)-phthalazinone chemical structure, C14H10N2O, CAS 5004-45-5
4-Phenyl-1-(2H)-phthalazinone
CAS 5004-45-5C14H10N2O
4-(3-Amino-4-methylphenyl)-2H-phthalazin-1-one chemical structure, C15H13N3O, CAS 843638-25-5
4-(3-Amino-4-methylphenyl)-2H-phthalazin-1-one
CAS 843638-25-5C15H13N3O
4-(4-Carboxyphenyl)phthalazin-1(2H)-one chemical structure, C15H10N2O3, CAS 152567-94-7
4-(4-Carboxyphenyl)phthalazin-1(2H)-one
CAS 152567-94-7C15H10N2O3
4-(4-Bromophenyl)phthalazin-1(2H)-one chemical structure, C14H9BrN2O, CAS 76462-38-9
4-(4-Bromophenyl)phthalazin-1(2H)-one
CAS 76462-38-9C14H9BrN2O
4-(4-Chlorophenyl)phthalazin-1-ol chemical structure, C14H9ClN2O, CAS 51334-86-2
4-(4-Chlorophenyl)phthalazin-1-ol
CAS 51334-86-2C14H9ClN2O
4-(4-Methoxyphenyl)-1-(2H)-phthalazinone chemical structure, C15H12N2O2, CAS 57353-93-2
4-(4-Methoxyphenyl)-1-(2H)-phthalazinone
CAS 57353-93-2C15H12N2O2
Ethyl 2-(1-oxo-4-phenylphthalazin-2-yl)acetate chemical structure, C18H16N2O3, CAS 296876-23-8
Ethyl 2-(1-oxo-4-phenylphthalazin-2-yl)acetate
CAS 296876-23-8C18H16N2O3
2-[4-(4-Chlorophenyl)-1-oxophthalazin-2-yl]acetamide chemical structure, C16H12ClN3O2, CAS 684234-43-3
2-[4-(4-Chlorophenyl)-1-oxophthalazin-2-yl]acetamide
CAS 684234-43-3C16H12ClN3O2
2-(4-(4-Chlorophenyl)-1-oxo-2(1H)-phthalazinyl)-N-methylacetamide chemical structure, C17H14ClN3O2, CAS 684234-44-4
2-(4-(4-Chlorophenyl)-1-oxo-2(1H)-phthalazinyl)-N-methylacetamide
CAS 684234-44-4C17H14ClN3O2
2-Methyl-5-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)benzenesulfonamide chemical structure, C16H15N3O3S, CAS 684234-96-6
2-Methyl-5-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)benzenesulfonamide
CAS 684234-96-6C16H15N3O3S
2-(1-Oxo-4-phenyl-2(1H)-phthalazinyl)acetohydrazide chemical structure, C16H14N4O2, CAS 126080-81-7
2-(1-Oxo-4-phenyl-2(1H)-phthalazinyl)acetohydrazide
CAS 126080-81-7C16H14N4O2
2-[4-(4-Methylphenyl)-1-oxophthalazin-2-yl]acetamide chemical structure, C17H15N3O2, CAS 333742-05-5
2-[4-(4-Methylphenyl)-1-oxophthalazin-2-yl]acetamide
CAS 333742-05-5C17H15N3O2
N-Methyl-2-[4-(4-methylphenyl)-1-oxophthalazin-2-yl]acetamide chemical structure, C18H17N3O2, CAS 333742-06-6
N-Methyl-2-[4-(4-methylphenyl)-1-oxophthalazin-2-yl]acetamide
CAS 333742-06-6C18H17N3O2
N,N-Dimethyl-2-[4-(4-methylphenyl)-1-oxophthalazin-2-yl]acetamide chemical structure, C19H19N3O2, CAS 374772-28-8
N,N-Dimethyl-2-[4-(4-methylphenyl)-1-oxophthalazin-2-yl]acetamide
CAS 374772-28-8C19H19N3O2
Methyl 2-[4-(4-methylphenyl)-1-oxophthalazin-2-yl]acetate chemical structure, C18H16N2O3, CAS 333742-09-9
Methyl 2-[4-(4-methylphenyl)-1-oxophthalazin-2-yl]acetate
CAS 333742-09-9C18H16N2O3
4-(4-Fluorophenyl)-1,2-dihydrophthalazin-1-one chemical structure, C14H9FN2O, CAS 1766-63-8
4-(4-Fluorophenyl)-1,2-dihydrophthalazin-1-one
CAS 1766-63-8C14H9FN2O
4-(3,4-Dimethylphenyl)phthalazin-1(2H)-one chemical structure, C16H14N2O, CAS 93517-74-9
4-(3,4-Dimethylphenyl)phthalazin-1(2H)-one
CAS 93517-74-9C16H14N2O
2-Isobutyl-4-phenylphthalazin-1(2H)-one chemical structure, C18H18N2O, CAS 329066-79-7
2-Isobutyl-4-phenylphthalazin-1(2H)-one
CAS 329066-79-7C18H18N2O
N,N-Dimethyl-4-(4-oxo-3H-phthalazin-1-yl)benzamide chemical structure, C17H15N3O2, CAS 333438-92-9
N,N-Dimethyl-4-(4-oxo-3H-phthalazin-1-yl)benzamide
CAS 333438-92-9C17H15N3O2
4-(4-Ethylphenyl)phthalazin-1(2H)-one chemical structure, C16H14N2O, CAS 102990-37-4
4-(4-Ethylphenyl)phthalazin-1(2H)-one
CAS 102990-37-4C16H14N2O
Methyl (1-oxo-4-phenyl-2(1H)-phthalazinyl)acetate chemical structure, C17H14N2O3, CAS 389126-76-5
Methyl (1-oxo-4-phenyl-2(1H)-phthalazinyl)acetate
CAS 389126-76-5C17H14N2O3
N-[2-Methoxy-5-(3-methyl-4-oxophthalazin-1-yl)phenyl]propanamide chemical structure, C19H19N3O3, CAS 685131-62-8
N-[2-Methoxy-5-(3-methyl-4-oxophthalazin-1-yl)phenyl]propanamide
CAS 685131-62-8C19H19N3O3
4-[3-(Hydroxymethyl)-4-methylphenyl]-2-methylphthalazin-1-one chemical structure, C17H16N2O2, CAS 694462-65-2
4-[3-(Hydroxymethyl)-4-methylphenyl]-2-methylphthalazin-1-one
CAS 694462-65-2C17H16N2O2
[2-Methyl-5-(3-methyl-4-oxophthalazin-1-yl)phenyl]methyl acetate chemical structure, C19H18N2O3, CAS 694467-05-5
[2-Methyl-5-(3-methyl-4-oxophthalazin-1-yl)phenyl]methyl acetate
CAS 694467-05-5C19H18N2O3