Murcko scaffold
Ring system with 4 rings and 30 atoms
23 chemicals on CompoundList share this ring system.
- Rings
- 4
- Scaffold atoms
- 30
- Chemicals
- 23
- With full pages
- 6
Scaffold SMILES
O=C(Nc1nc(-c2ccccc2)cs1)c1ccccc1NS(=O)(=O)c1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 23 of 23 chemicals
![N-[4-(4-Fluorophenyl)-2-thiazolyl]-2-[(4-methylphenyl)sulfonylamino]benzamide chemical structure, C23H18FN3O3S2, CAS 330190-15-3](/s/XWAUCQGRYNYIOT-UHFFFAOYSA-N.svg)
N-[4-(4-Fluorophenyl)-2-thiazolyl]-2-[(4-methylphenyl)sulfonylamino]benzamide
CAS 330190-15-3C23H18FN3O3S2
![2-[(4-Methylphenyl)sulfonylamino]-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzamide chemical structure, C23H18N4O5S2, CAS 328027-79-8](/s/CAACYGLLVKRWAJ-UHFFFAOYSA-N.svg)
2-[(4-Methylphenyl)sulfonylamino]-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzamide
CAS 328027-79-8C23H18N4O5S2
![2-[(3,4-Difluorophenyl)sulfonylamino]-N-[4-(4-methoxyphenyl)thiazol-2-yl]benzamide chemical structure, C23H17F2N3O4S2, CAS 748772-66-9](/s/CUQBLPWFKHAAND-UHFFFAOYSA-N.svg)
2-[(3,4-Difluorophenyl)sulfonylamino]-N-[4-(4-methoxyphenyl)thiazol-2-yl]benzamide
CAS 748772-66-9C23H17F2N3O4S2
![N-[4-(3,4-Dimethylphenyl)-1,3-thiazol-2-yl]-2-[(4-methylphenyl)sulfonylamino]benzamide chemical structure, C25H23N3O3S2, CAS 361469-76-3](/s/WIDPEHVLVIGBSI-UHFFFAOYSA-N.svg)
N-[4-(3,4-Dimethylphenyl)-1,3-thiazol-2-yl]-2-[(4-methylphenyl)sulfonylamino]benzamide
CAS 361469-76-3C25H23N3O3S2
![Methyl 4-[2-[[2-[(4-methylphenyl)sulfonylamino]benzoyl]amino]-1,3-thiazol-4-yl]benzoate chemical structure, C25H21N3O5S2, CAS 441291-07-2](/s/ORFDLWSWRRQVQG-UHFFFAOYSA-N.svg)
Methyl 4-[2-[[2-[(4-methylphenyl)sulfonylamino]benzoyl]amino]-1,3-thiazol-4-yl]benzoate
CAS 441291-07-2C25H21N3O5S2
![2-[(4-Methylphenyl)sulfonylamino]-N-[4-(2,4,6-trimethylphenyl)-1,3-thiazol-2-yl]benzamide chemical structure, C26H25N3O3S2, CAS 476279-95-5](/s/WHAFXHJLUHBYQB-UHFFFAOYSA-N.svg)
2-[(4-Methylphenyl)sulfonylamino]-N-[4-(2,4,6-trimethylphenyl)-1,3-thiazol-2-yl]benzamide
CAS 476279-95-5C26H25N3O3S2
![Ethyl 2-[[2-[(4-methylphenyl)sulfonylamino]benzoyl]amino]-4-phenyl-1,3-thiazole-5-carboxylate chemical structure, C26H23N3O5S2, CAS 361469-83-2](/s/SYMDBBISSFWHOI-UHFFFAOYSA-N.svg)
Ethyl 2-[[2-[(4-methylphenyl)sulfonylamino]benzoyl]amino]-4-phenyl-1,3-thiazole-5-carboxylate
CAS 361469-83-2C26H23N3O5S2
![N-[4-(4-Cyanophenyl)-1,3-thiazol-2-yl]-2-[(4-methylphenyl)sulfonylamino]benzamide chemical structure, C24H18N4O3S2, CAS 330190-16-4](/s/HTDIQECEAQBCSE-UHFFFAOYSA-N.svg)
N-[4-(4-Cyanophenyl)-1,3-thiazol-2-yl]-2-[(4-methylphenyl)sulfonylamino]benzamide
CAS 330190-16-4C24H18N4O3S2
![2-[(4-Methylphenyl)sulfonylamino]-N-[4-(4-propoxyphenyl)-1,3-thiazol-2-yl]benzamide chemical structure, C26H25N3O4S2, CAS 361469-87-6](/s/QAYYCPDWCJALCC-UHFFFAOYSA-N.svg)
2-[(4-Methylphenyl)sulfonylamino]-N-[4-(4-propoxyphenyl)-1,3-thiazol-2-yl]benzamide
CAS 361469-87-6C26H25N3O4S2
![N-[4-(3,4-Dimethoxyphenyl)-1,3-thiazol-2-yl]-2-[(4-methylphenyl)sulfonylamino]benzamide chemical structure, C25H23N3O5S2, CAS 442535-84-4](/s/COKKVCDDGKRDNJ-UHFFFAOYSA-N.svg)
N-[4-(3,4-Dimethoxyphenyl)-1,3-thiazol-2-yl]-2-[(4-methylphenyl)sulfonylamino]benzamide
CAS 442535-84-4C25H23N3O5S2
![N-[4-(2,4-Dimethylphenyl)-1,3-thiazol-2-yl]-2-[(4-methylphenyl)sulfonylamino]benzamide chemical structure, C25H23N3O3S2, CAS 442535-83-3](/s/GEBBCZVTOULHQT-UHFFFAOYSA-N.svg)
N-[4-(2,4-Dimethylphenyl)-1,3-thiazol-2-yl]-2-[(4-methylphenyl)sulfonylamino]benzamide
CAS 442535-83-3C25H23N3O3S2
![N-[4-(4-Methoxyphenyl)-1,3-thiazol-2-yl]-2-[(4-methylphenyl)sulfonylamino]benzamide chemical structure, C24H21N3O4S2, CAS 330190-13-1](/s/VJHUYDLSNDDSJO-UHFFFAOYSA-N.svg)
N-[4-(4-Methoxyphenyl)-1,3-thiazol-2-yl]-2-[(4-methylphenyl)sulfonylamino]benzamide
CAS 330190-13-1C24H21N3O4S2
![N-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-2-[(4-methylphenyl)sulfonylamino]benzamide chemical structure, C23H18ClN3O3S2, CAS 313395-55-0](/s/TVVIHTZZZUMACI-UHFFFAOYSA-N.svg)
N-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-2-[(4-methylphenyl)sulfonylamino]benzamide
CAS 313395-55-0C23H18ClN3O3S2
![N-[4-(2,5-Dichlorophenyl)-1,3-thiazol-2-yl]-2-(4-methylbenzenesulfonamido)benzamide chemical structure, C23H17Cl2N3O3S2, CAS 361469-79-6](/s/VVVKQQZYXOMELI-UHFFFAOYSA-N.svg)
N-[4-(2,5-Dichlorophenyl)-1,3-thiazol-2-yl]-2-(4-methylbenzenesulfonamido)benzamide
CAS 361469-79-6C23H17Cl2N3O3S2
![N-[4-(4-Iodophenyl)-1,3-thiazol-2-yl]-2-[(4-methylphenyl)sulfonylamino]benzamide chemical structure, C23H18IN3O3S2, CAS 330190-14-2](/s/DCHSONUPQGJCSW-UHFFFAOYSA-N.svg)
N-[4-(4-Iodophenyl)-1,3-thiazol-2-yl]-2-[(4-methylphenyl)sulfonylamino]benzamide
CAS 330190-14-2C23H18IN3O3S2
![2-[(4-Methylphenyl)sulfonylamino]-N-(4-phenyl-1,3-thiazol-2-yl)benzamide chemical structure, C23H19N3O3S2, CAS 442535-81-1](/s/ZMEYHSRZMDFJOI-UHFFFAOYSA-N.svg)
2-[(4-Methylphenyl)sulfonylamino]-N-(4-phenyl-1,3-thiazol-2-yl)benzamide
CAS 442535-81-1C23H19N3O3S2
![N-[4-(4-Bromophenyl)-1,3-thiazol-2-yl]-2-[(4-methylphenyl)sulfonylamino]benzamide chemical structure, C23H18BrN3O3S2, CAS 361469-73-0](/s/KMAGQDFHWRWQFB-UHFFFAOYSA-N.svg)
N-[4-(4-Bromophenyl)-1,3-thiazol-2-yl]-2-[(4-methylphenyl)sulfonylamino]benzamide
CAS 361469-73-0C23H18BrN3O3S2
![N-[4-(2,5-Dimethylphenyl)-1,3-thiazol-2-yl]-2-[(4-methylphenyl)sulfonylamino]benzamide chemical structure, C25H23N3O3S2, CAS 442535-82-2](/s/ZSJKSUXYONYJSY-UHFFFAOYSA-N.svg)
N-[4-(2,5-Dimethylphenyl)-1,3-thiazol-2-yl]-2-[(4-methylphenyl)sulfonylamino]benzamide
CAS 442535-82-2C25H23N3O3S2
![2-[(4-Methylphenyl)sulfonylamino]-N-[4-(4-methylphenyl)-1,3-thiazol-2-yl]benzamide chemical structure, C24H21N3O3S2, CAS 361469-69-4](/s/HRNYULXQWNVZNT-UHFFFAOYSA-N.svg)
2-[(4-Methylphenyl)sulfonylamino]-N-[4-(4-methylphenyl)-1,3-thiazol-2-yl]benzamide
CAS 361469-69-4C24H21N3O3S2
![2-Benzenesulfonamido-N-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]benzamide chemical structure, C23H16N4O3S2, CAS 898465-78-6](/s/XAICBAPNLVKJFS-UHFFFAOYSA-N.svg)
2-Benzenesulfonamido-N-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]benzamide
CAS 898465-78-6C23H16N4O3S2
![N-[4-(4-Cyanophenyl)-1,3-thiazol-2-yl]-2-(4-methoxybenzenesulfonamido)benzamide chemical structure, C24H18N4O4S2, CAS 898421-57-3](/s/UJXOURZNIAWILV-UHFFFAOYSA-N.svg)
N-[4-(4-Cyanophenyl)-1,3-thiazol-2-yl]-2-(4-methoxybenzenesulfonamido)benzamide
CAS 898421-57-3C24H18N4O4S2
![2-[(4-Methylphenyl)sulfonylamino]-N-(4-phenyl-1,3-thiazol-2-yl)-4-(trifluoromethyl)benzamide chemical structure, C24H18F3N3O3S2, CAS 1991986-30-1](/s/QZUGMNXETPARLI-UHFFFAOYSA-N.svg)
2-[(4-Methylphenyl)sulfonylamino]-N-(4-phenyl-1,3-thiazol-2-yl)-4-(trifluoromethyl)benzamide
CAS 1991986-30-1C24H18F3N3O3S2
![N-[4-(4-Bromophenyl)-1,3-thiazol-2-yl]-2-(4-methylbenzenesulfonamido)-5-(trifluoromethyl)benzamide chemical structure, C24H17BrF3N3O3S2, CAS 3058587-77-9](/s/KLWZKWRHGMGJRU-UHFFFAOYSA-N.svg)
N-[4-(4-Bromophenyl)-1,3-thiazol-2-yl]-2-(4-methylbenzenesulfonamido)-5-(trifluoromethyl)benzamide
CAS 3058587-77-9C24H17BrF3N3O3S2
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold O=C(Nc1c[nH]n(-c2ccccc2)c1=O)c1ccccc1NS(=O)(=O)c1ccccc1](/scaffold/RVYURNPXKUEGCN-UHFFFAOYSA-N/structure.svg)
![Scaffold O=c1c(NCc2ccccc2NS(=O)(=O)c2ccccc2)c[nH]n1-c1ccccc1](/scaffold/XVPTWUQFUMUDJJ-UHFFFAOYSA-N/structure.svg)