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Murcko scaffold

Piperazine-2,6-dione scaffold

63 chemicals on CompoundList share this ring system.

Rings
1
Scaffold atoms
8
Chemicals
63
With full pages
7
Scaffold SMILES

O=C1CNCC(=O)N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the Piperazine-2,6-dione page
Murcko scaffold O=C1CNCC(=O)N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 63 chemicals

4-Methylpiperazine-2,6-dione chemical structure, C5H8N2O2, CAS 60725-35-1
4-Methylpiperazine-2,6-dione
CAS 60725-35-1C5H8N2O2
Piperazine-2,6-dione chemical structure, C4H6N2O2, CAS 4774-22-5
Piperazine-2,6-dione
CAS 4774-22-5C4H6N2O2
2-(3,5-Dioxopiperazin-1-yl)acetamide chemical structure, C6H9N3O3, CAS 24553-06-8
2-(3,5-Dioxopiperazin-1-yl)acetamide
CAS 24553-06-8C6H9N3O3
3,5-Dioxopiperazine-1-carbaldehyde chemical structure, C5H6N2O3, CAS 165824-59-9
3,5-Dioxopiperazine-1-carbaldehyde
CAS 165824-59-9C5H6N2O3
4-Butanoylpiperazine-2,6-dione chemical structure, C8H12N2O3, CAS 374601-95-3
4-Butanoylpiperazine-2,6-dione
CAS 374601-95-3C8H12N2O3
4-Dodecanoylpiperazine-2,6-dione chemical structure, C16H28N2O3, CAS 175136-49-9
4-Dodecanoylpiperazine-2,6-dione
CAS 175136-49-9C16H28N2O3
2,6-Piperazinedione,4-(3-methyl-1-oxobutyl)-(9CI) chemical structure, C9H14N2O3, CAS 419538-87-7
2,6-Piperazinedione,4-(3-methyl-1-oxobutyl)-(9CI)
CAS 419538-87-7C9H14N2O3
2-(3,5-Dioxopiperazin-1-yl)propanamide chemical structure, C7H11N3O3, CAS 89260-77-5
2-(3,5-Dioxopiperazin-1-yl)propanamide
CAS 89260-77-5C7H11N3O3
2-(3,5-Dioxopiperazin-1-yl)acetic acid chemical structure, C6H8N2O4, CAS 127510-13-8
2-(3,5-Dioxopiperazin-1-yl)acetic acid
CAS 127510-13-8C6H8N2O4
Ethyl 3-(4-methyl-2,6-dioxopiperazin-1-yl)propanoate chemical structure, C10H16N2O4, CAS 875159-72-1
Ethyl 3-(4-methyl-2,6-dioxopiperazin-1-yl)propanoate
CAS 875159-72-1C10H16N2O4
Methyl 2-(3,5-dioxopiperazin-1-yl)acetate chemical structure, C7H10N2O4, CAS 434314-27-9
Methyl 2-(3,5-dioxopiperazin-1-yl)acetate
CAS 434314-27-9C7H10N2O4
N-[2-(3,5-Dioxopiperazino)propyl]-N-(2-amino-2-oxoethyl)glycine chemical structure, C11H18N4O5, CAS 153042-70-7
N-[2-(3,5-Dioxopiperazino)propyl]-N-(2-amino-2-oxoethyl)glycine
CAS 153042-70-7C11H18N4O5
(4-Methyl-3,5-dioxopiperazin-1-yl)acetic acid chemical structure, C7H10N2O4, CAS 173681-12-4
(4-Methyl-3,5-dioxopiperazin-1-yl)acetic acid
CAS 173681-12-4C7H10N2O4
(3R)-3-Methylpiperazine-2,6-dione chemical structure, C5H8N2O2, CAS 434314-23-5
(3R)-3-Methylpiperazine-2,6-dione
CAS 434314-23-5C5H8N2O2
3-Ethylpiperazine-2,6-dione chemical structure, C6H10N2O2, CAS 434314-24-6
3-Ethylpiperazine-2,6-dione
CAS 434314-24-6C6H10N2O2
Piperazine-2,6-dione hydrochloride chemical structure, C4H7ClN2O2, CAS 35975-30-5
Piperazine-2,6-dione hydrochloride
CAS 35975-30-5C4H7ClN2O2
4-Acetylpiperazine-2,6-dione chemical structure, C6H8N2O3, CAS 35975-27-0
4-Acetylpiperazine-2,6-dione
CAS 35975-27-0C6H8N2O3
4-(2-Propylpentanoyl)piperazine-2,6-dione chemical structure, C12H20N2O3, CAS 89508-11-2
4-(2-Propylpentanoyl)piperazine-2,6-dione
CAS 89508-11-2C12H20N2O3
1,3,3,4,5,5-Hexamethylpiperazine-2,6-dione chemical structure, C10H18N2O2, CAS 88876-30-6
1,3,3,4,5,5-Hexamethylpiperazine-2,6-dione
CAS 88876-30-6C10H18N2O2
1,4-Diethyl-3,3,5,5-tetramethylpiperazine-2,6-dione chemical structure, C12H22N2O2, CAS 88876-31-7
1,4-Diethyl-3,3,5,5-tetramethylpiperazine-2,6-dione
CAS 88876-31-7C12H22N2O2
3,5-Dioxo-1-piperazinebutanoic acid chemical structure, C8H12N2O4, CAS 244161-12-4
3,5-Dioxo-1-piperazinebutanoic acid
CAS 244161-12-4C8H12N2O4
N-(2-Amino-2-oxoethyl)-N-[(1S)-2-(3,5-dioxo-1-piperazinyl)-1-methylethyl]-glycine chemical structure, C11H18N4O5, CAS 120418-77-1
N-(2-Amino-2-oxoethyl)-N-[(1S)-2-(3,5-dioxo-1-piperazinyl)-1-methylethyl]-glycine
CAS 120418-77-1C11H18N4O5
N-(2-Amino-2-oxoethyl)-N-[(2S)-2-(3,5-dioxo-1-piperazinyl)propyl]-glycine chemical structure, C11H18N4O5, CAS 120418-76-0
N-(2-Amino-2-oxoethyl)-N-[(2S)-2-(3,5-dioxo-1-piperazinyl)propyl]-glycine
CAS 120418-76-0C11H18N4O5
tert-Butyl 4-methyl-3,5-dioxopiperazine-1-carboxylate chemical structure, C10H16N2O4, CAS 873221-65-9
tert-Butyl 4-methyl-3,5-dioxopiperazine-1-carboxylate
CAS 873221-65-9C10H16N2O4