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Murcko scaffold

N-Phenyl-2-((4-phenyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)thio)acetamide scaffold

121 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 28
Chemicals: 121
With full pages: 54

Scaffold SMILES

O=C(CSc1nnc(-c2cccnc2)n1-c1ccccc1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold Open the N-Phenyl-2-((4-phenyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)thio)acetamide page

Murcko scaffold O=C(CSc1nnc(-c2cccnc2)n1-c1ccccc1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 121 chemicals

2-{[4-(4-Ethoxyphenyl)-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(2-methylphenyl)acetamide chemical structure, C24H23N5O2S, CAS 499125-77-8

2-{[4-(4-Ethoxyphenyl)-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(2-methylphenyl)acetamide

CAS 499125-77-8C₂₄H₂₃N₅O₂S

2-((4-(4-Ethoxyphenyl)-5-(3-pyridinyl)-4H-1,2,4-triazol-3-yl)sulfanyl)-N-(4-fluorophenyl)acetamide chemical structure, C23H20FN5O2S, CAS 477332-67-5

2-((4-(4-Ethoxyphenyl)-5-(3-pyridinyl)-4H-1,2,4-triazol-3-yl)sulfanyl)-N-(4-fluorophenyl)acetamide

CAS 477332-67-5C₂₃H₂₀FN₅O₂S

2-{[4-(4-Ethoxyphenyl)-5-(3-pyridinyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(2-fluorophenyl)acetamide chemical structure, C23H20FN5O2S, CAS 477330-63-5

2-{[4-(4-Ethoxyphenyl)-5-(3-pyridinyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(2-fluorophenyl)acetamide

CAS 477330-63-5C₂₃H₂₀FN₅O₂S

2-((4-(4-Ethoxyphenyl)-5-(3-pyridinyl)-4H-1,2,4-triazol-3-yl)sulfanyl)-N-(3-fluorophenyl)acetamide chemical structure, C23H20FN5O2S, CAS 477330-95-3

2-((4-(4-Ethoxyphenyl)-5-(3-pyridinyl)-4H-1,2,4-triazol-3-yl)sulfanyl)-N-(3-fluorophenyl)acetamide

CAS 477330-95-3C₂₃H₂₀FN₅O₂S

N-[2-Chloro-5-(trifluoromethyl)phenyl]-2-[(4-phenyl-5-pyridin-3-yl-1,2,4-triazol-3-yl)sulfanyl]acetamide chemical structure, C22H15ClF3N5OS, CAS 333324-25-7

N-[2-Chloro-5-(trifluoromethyl)phenyl]-2-[(4-phenyl-5-pyridin-3-yl-1,2,4-triazol-3-yl)sulfanyl]acetamide

CAS 333324-25-7C₂₂H₁₅ClF₃N₅OS

N-(3-Chlorophenyl)-2-((4-phenyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)thio)acetamide chemical structure, C21H16ClN5OS, CAS 332385-34-9

N-(3-Chlorophenyl)-2-((4-phenyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)thio)acetamide

CAS 332385-34-9C₂₁H₁₆ClN₅OS

N-(4-Acetylphenyl)-2-((4-phenyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)thio)acetamide chemical structure, C23H19N5O2S, CAS 332385-36-1

N-(4-Acetylphenyl)-2-((4-phenyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)thio)acetamide

CAS 332385-36-1C₂₃H₁₉N₅O₂S

N-(4-Acetylphenyl)-2-({4-[4-(methyloxy)phenyl]-5-pyridin-3-yl-4H-1,2,4-triazol-3-yl}sulfanyl)acetamide chemical structure, C24H21N5O3S, CAS 333408-43-8

N-(4-Acetylphenyl)-2-({4-[4-(methyloxy)phenyl]-5-pyridin-3-yl-4H-1,2,4-triazol-3-yl}sulfanyl)acetamide

CAS 333408-43-8C₂₄H₂₁N₅O₃S

N-(2,4-Dimethoxyphenyl)-2-{[4-phenyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide chemical structure, C23H21N5O3S, CAS 483308-26-5

N-(2,4-Dimethoxyphenyl)-2-{[4-phenyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide

CAS 483308-26-5C₂₃H₂₁N₅O₃S

N-Phenyl-2-((4-phenyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)thio)acetamide chemical structure, C21H17N5OS, CAS 332385-31-6

N-Phenyl-2-((4-phenyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)thio)acetamide

CAS 332385-31-6C₂₁H₁₇N₅OS

N-(3,4-Difluorophenyl)-2-((4-(4-ethoxyphenyl)-5-(3-pyridinyl)-4H-1,2,4-triazol-3-yl)sulfanyl)acetamide chemical structure, C23H19F2N5O2S, CAS 477330-08-8

N-(3,4-Difluorophenyl)-2-((4-(4-ethoxyphenyl)-5-(3-pyridinyl)-4H-1,2,4-triazol-3-yl)sulfanyl)acetamide

CAS 477330-08-8C₂₃H₁₉F₂N₅O₂S

N-(3-Acetylphenyl)-2-((4-phenyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)thio)acetamide chemical structure, C23H19N5O2S, CAS 332909-83-8

N-(3-Acetylphenyl)-2-((4-phenyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)thio)acetamide

CAS 332909-83-8C₂₃H₁₉N₅O₂S

N-(2,4-Difluorophenyl)-2-{[4-(4-ethoxyphenyl)-5-(3-pyridinyl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide chemical structure, C23H19F2N5O2S, CAS 618432-47-6

N-(2,4-Difluorophenyl)-2-{[4-(4-ethoxyphenyl)-5-(3-pyridinyl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide

CAS 618432-47-6C₂₃H₁₉F₂N₅O₂S

N-(2,5-Dichlorophenyl)-2-{[4-(4-ethoxyphenyl)-5-(3-pyridinyl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide chemical structure, C23H19Cl2N5O2S, CAS 499125-79-0

N-(2,5-Dichlorophenyl)-2-{[4-(4-ethoxyphenyl)-5-(3-pyridinyl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide

CAS 499125-79-0C₂₃H₁₉Cl₂N₅O₂S

N-(2,4-Dichlorophenyl)-2-{[4-(4-ethoxyphenyl)-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide chemical structure, C23H19Cl2N5O2S, CAS 613227-30-8

N-(2,4-Dichlorophenyl)-2-{[4-(4-ethoxyphenyl)-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide

CAS 613227-30-8C₂₃H₁₉Cl₂N₅O₂S

N-(2,4-Dimethoxyphenyl)-2-{[4-(4-ethoxyphenyl)-5-(3-pyridinyl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide chemical structure, C25H25N5O4S, CAS 477330-22-6

N-(2,4-Dimethoxyphenyl)-2-{[4-(4-ethoxyphenyl)-5-(3-pyridinyl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide

CAS 477330-22-6C₂₅H₂₅N₅O₄S

ME 4-((((4-(4-BR-PH)-5-(3-Pyridinyl)4H-1,2,4-triazol-3-yl)thio)AC)amino)benzoate chemical structure, C23H18BrN5O3S, CAS 477329-64-9

ME 4-((((4-(4-BR-PH)-5-(3-Pyridinyl)4H-1,2,4-triazol-3-yl)thio)AC)amino)benzoate

CAS 477329-64-9C₂₃H₁₈BrN₅O₃S

2-{[4-(4-Bromophenyl)-5-(3-pyridinyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(2,4-dimethoxyphenyl)acetamide chemical structure, C23H20BrN5O3S, CAS 477330-98-6

2-{[4-(4-Bromophenyl)-5-(3-pyridinyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(2,4-dimethoxyphenyl)acetamide

CAS 477330-98-6C₂₃H₂₀BrN₅O₃S

N-(3,4-Dichlorophenyl)-2-[(4-phenyl-5-pyridin-3-yl-1,2,4-triazol-3-yl)sulfanyl]acetamide chemical structure, C21H15Cl2N5OS, CAS 525582-86-9

N-(3,4-Dichlorophenyl)-2-[(4-phenyl-5-pyridin-3-yl-1,2,4-triazol-3-yl)sulfanyl]acetamide

CAS 525582-86-9C₂₁H₁₅Cl₂N₅OS

N-(4-Bromophenyl)-2-[(4-phenyl-5-pyridin-3-yl-1,2,4-triazol-3-yl)sulfanyl]acetamide chemical structure, C21H16BrN5OS, CAS 142529-82-6

N-(4-Bromophenyl)-2-[(4-phenyl-5-pyridin-3-yl-1,2,4-triazol-3-yl)sulfanyl]acetamide

CAS 142529-82-6C₂₁H₁₆BrN₅OS

2-{[4-(4-Bromophenyl)-5-(3-pyridinyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(2-ethoxyphenyl)acetamide chemical structure, C23H20BrN5O2S, CAS 477330-03-3

2-{[4-(4-Bromophenyl)-5-(3-pyridinyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(2-ethoxyphenyl)acetamide

CAS 477330-03-3C₂₃H₂₀BrN₅O₂S

N-(2,6-Dimethylphenyl)-2-{[4-(4-ethoxyphenyl)-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide chemical structure, C25H25N5O2S, CAS 499125-76-7

N-(2,6-Dimethylphenyl)-2-{[4-(4-ethoxyphenyl)-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide

CAS 499125-76-7C₂₅H₂₅N₅O₂S

N-(2-Ethoxyphenyl)-2-{[4-(4-ethoxyphenyl)-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide chemical structure, C25H25N5O3S, CAS 613227-16-0

N-(2-Ethoxyphenyl)-2-{[4-(4-ethoxyphenyl)-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide

CAS 613227-16-0C₂₅H₂₅N₅O₃S

N-(4-Chlorophenyl)-2-{[4-(4-ethoxyphenyl)-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide chemical structure, C23H20ClN5O2S, CAS 499125-71-2

N-(4-Chlorophenyl)-2-{[4-(4-ethoxyphenyl)-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide

CAS 499125-71-2C₂₃H₂₀ClN₅O₂S