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Murcko scaffold

Ring system with 4 rings and 26 atoms

93 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
26
Chemicals
93
With full pages
8
Scaffold SMILES

O=C1CN(C(=O)c2ccccc2)C(c2ccccc2)c2ccccc2N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1CN(C(=O)c2ccccc2)C(c2ccccc2)c2ccccc2N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 93 chemicals

7-Methyl-5-phenyl-4-[(3,4,5-trimethoxyphenyl)carbonyl]-1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one chemical structure, C26H26N2O5, CAS 328110-71-0
7-Methyl-5-phenyl-4-[(3,4,5-trimethoxyphenyl)carbonyl]-1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one
CAS 328110-71-0C26H26N2O5
4-Benzoyl-7-bromo-5-phenyl-3,5-dihydro-1H-1,4-benzodiazepin-2-one chemical structure, C22H17BrN2O2, CAS 313225-58-0
4-Benzoyl-7-bromo-5-phenyl-3,5-dihydro-1H-1,4-benzodiazepin-2-one
CAS 313225-58-0C22H17BrN2O2
4-Benzoyl-7-bromo-5-(2-chlorophenyl)-1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one chemical structure, C22H16BrClN2O2, CAS 312758-74-0
4-Benzoyl-7-bromo-5-(2-chlorophenyl)-1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one
CAS 312758-74-0C22H16BrClN2O2
7-Bromo-5-(2-chlorophenyl)-4-[(3,4,5-trimethoxyphenyl)carbonyl]-1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one chemical structure, C25H22BrClN2O5, CAS 313650-46-3
7-Bromo-5-(2-chlorophenyl)-4-[(3,4,5-trimethoxyphenyl)carbonyl]-1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one
CAS 313650-46-3C25H22BrClN2O5
7-Bromo-4-(2-chlorobenzoyl)-5-(2-chlorophenyl)-3,5-dihydro-1H-1,4-benzodiazepin-2-one chemical structure, C22H15BrCl2N2O2, CAS 324759-68-4
7-Bromo-4-(2-chlorobenzoyl)-5-(2-chlorophenyl)-3,5-dihydro-1H-1,4-benzodiazepin-2-one
CAS 324759-68-4C22H15BrCl2N2O2
4-Benzoyl-7-methyl-5-phenyl-3,5-dihydro-1H-1,4-benzodiazepin-2-one chemical structure, C23H20N2O2, CAS 313262-71-4
4-Benzoyl-7-methyl-5-phenyl-3,5-dihydro-1H-1,4-benzodiazepin-2-one
CAS 313262-71-4C23H20N2O2
7-Bromo-4-(2-bromobenzoyl)-5-(2-chlorophenyl)-3,5-dihydro-1H-1,4-benzodiazepin-2-one chemical structure, C22H15Br2ClN2O2, CAS 364361-79-5
7-Bromo-4-(2-bromobenzoyl)-5-(2-chlorophenyl)-3,5-dihydro-1H-1,4-benzodiazepin-2-one
CAS 364361-79-5C22H15Br2ClN2O2
7-Bromo-4-(2-bromobenzoyl)-5-phenyl-1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one chemical structure, C22H16Br2N2O2, CAS 313262-75-8
7-Bromo-4-(2-bromobenzoyl)-5-phenyl-1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one
CAS 313262-75-8C22H16Br2N2O2
7-Bromo-4-(4-chlorobenzoyl)-5-phenyl-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one chemical structure, C22H16BrClN2O2, CAS 312606-26-1
7-Bromo-4-(4-chlorobenzoyl)-5-phenyl-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one
CAS 312606-26-1C22H16BrClN2O2
7-Bromo-4-(3-chlorobenzoyl)-5-phenyl-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one chemical structure, C22H16BrClN2O2, CAS 313683-86-2
7-Bromo-4-(3-chlorobenzoyl)-5-phenyl-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one
CAS 313683-86-2C22H16BrClN2O2
7-Bromo-5-phenyl-4-(3,4,5-trimethoxybenzoyl)-1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one chemical structure, C25H23BrN2O5, CAS 313650-45-2
7-Bromo-5-phenyl-4-(3,4,5-trimethoxybenzoyl)-1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one
CAS 313650-45-2C25H23BrN2O5
7-Bromo-4-(4-bromobenzoyl)-5-phenyl-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one chemical structure, C22H16Br2N2O2, CAS 313683-87-3
7-Bromo-4-(4-bromobenzoyl)-5-phenyl-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one
CAS 313683-87-3C22H16Br2N2O2
4-(7-Bromo-2-oxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-4-carbonyl)-N,N-diethylbenzenesulfonamide chemical structure, C26H26BrN3O4S, CAS 313683-91-9
4-(7-Bromo-2-oxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-4-carbonyl)-N,N-diethylbenzenesulfonamide
CAS 313683-91-9C26H26BrN3O4S
4-(2-Bromobenzoyl)-7-fluoro-5-phenyl-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one chemical structure, C22H16BrFN2O2, CAS 533887-70-6
4-(2-Bromobenzoyl)-7-fluoro-5-phenyl-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one
CAS 533887-70-6C22H16BrFN2O2
4-(5-Chloro-2-nitrobenzoyl)-7-fluoro-5-(4-fluorophenyl)-3,5-dihydro-1H-1,4-benzodiazepin-2-one chemical structure, C22H14ClF2N3O4, CAS 533888-46-9
4-(5-Chloro-2-nitrobenzoyl)-7-fluoro-5-(4-fluorophenyl)-3,5-dihydro-1H-1,4-benzodiazepin-2-one
CAS 533888-46-9C22H14ClF2N3O4
7-Bromo-4-(2,4-dichlorobenzoyl)-5-phenyl-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one chemical structure, C22H15BrCl2N2O2, CAS 391218-98-7
7-Bromo-4-(2,4-dichlorobenzoyl)-5-phenyl-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one
CAS 391218-98-7C22H15BrCl2N2O2
7-Chloro-4-(2-iodobenzoyl)-5-phenyl-3,5-dihydro-1H-1,4-benzodiazepin-2-one chemical structure, C22H16ClIN2O2, CAS 533878-84-1
7-Chloro-4-(2-iodobenzoyl)-5-phenyl-3,5-dihydro-1H-1,4-benzodiazepin-2-one
CAS 533878-84-1C22H16ClIN2O2
7-Chloro-4-(2-chloro-6-fluorobenzoyl)-5-phenyl-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one chemical structure, C22H15Cl2FN2O2, CAS 533879-26-4
7-Chloro-4-(2-chloro-6-fluorobenzoyl)-5-phenyl-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one
CAS 533879-26-4C22H15Cl2FN2O2
4-(3,5-Dimethylbenzoyl)-7-fluoro-5-(4-fluorophenyl)-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one chemical structure, C24H20F2N2O2, CAS 533880-27-2
4-(3,5-Dimethylbenzoyl)-7-fluoro-5-(4-fluorophenyl)-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one
CAS 533880-27-2C24H20F2N2O2
7-Bromo-4-(3-fluorobenzoyl)-5-(4-fluorophenyl)-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one chemical structure, C22H15BrF2N2O2, CAS 533876-25-4
7-Bromo-4-(3-fluorobenzoyl)-5-(4-fluorophenyl)-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one
CAS 533876-25-4C22H15BrF2N2O2
7-Chloro-4-(4-methyl-3-nitrobenzoyl)-5-phenyl-3,5-dihydro-1H-1,4-benzodiazepin-2-one chemical structure, C23H18ClN3O4, CAS 533879-47-9
7-Chloro-4-(4-methyl-3-nitrobenzoyl)-5-phenyl-3,5-dihydro-1H-1,4-benzodiazepin-2-one
CAS 533879-47-9C23H18ClN3O4
7-Chloro-4-(3,5-dimethylbenzoyl)-5-phenyl-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one chemical structure, C24H21ClN2O2, CAS 313262-78-1
7-Chloro-4-(3,5-dimethylbenzoyl)-5-phenyl-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one
CAS 313262-78-1C24H21ClN2O2
7-Chloro-4-(2-nitrobenzoyl)-5-phenyl-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-2-one chemical structure, C22H16ClN3O4, CAS 533878-87-4
7-Chloro-4-(2-nitrobenzoyl)-5-phenyl-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-2-one
CAS 533878-87-4C22H16ClN3O4
4-(5-Bromo-2-chlorobenzoyl)-7-chloro-5-(4-fluorophenyl)-3,5-dihydro-1H-1,4-benzodiazepin-2-one chemical structure, C22H14BrCl2FN2O2, CAS 533879-30-0
4-(5-Bromo-2-chlorobenzoyl)-7-chloro-5-(4-fluorophenyl)-3,5-dihydro-1H-1,4-benzodiazepin-2-one
CAS 533879-30-0C22H14BrCl2FN2O2