Murcko scaffold
Ring system with 4 rings and 26 atoms
93 chemicals on CompoundList share this ring system.
- Rings
- 4
- Scaffold atoms
- 26
- Chemicals
- 93
- With full pages
- 8
Scaffold SMILES
O=C1CN(C(=O)c2ccccc2)C(c2ccccc2)c2ccccc2N1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 49 to 93 of 93 chemicals
![4-(3-Bromobenzoyl)-7-chloro-5-phenyl-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one chemical structure, C22H16BrClN2O2, CAS 312606-39-6](/s/JXOMJAHFOPKVOF-UHFFFAOYSA-N.svg)
4-(3-Bromobenzoyl)-7-chloro-5-phenyl-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one
CAS 312606-39-6C22H16BrClN2O2
4-(5-Chloro-2-nitrobenzoyl)-7-fluoro-5-phenyl-3,5-dihydro-1H-1,4-benzodiazepin-2-one
CAS 533888-45-8C22H15ClFN3O4
![5-(4-Fluorophenyl)-7-methyl-4-[3-(trifluoromethyl)benzoyl]-3,5-dihydro-1H-1,4-benzodiazepin-2-one chemical structure, C24H18F4N2O2, CAS 533874-08-7](/s/YHEQRJQVMVNLFM-UHFFFAOYSA-N.svg)
5-(4-Fluorophenyl)-7-methyl-4-[3-(trifluoromethyl)benzoyl]-3,5-dihydro-1H-1,4-benzodiazepin-2-one
CAS 533874-08-7C24H18F4N2O2
7-Bromo-4-(2,6-difluorobenzoyl)-5-phenyl-3,5-dihydro-1H-1,4-benzodiazepin-2-one
CAS 533876-70-9C22H15BrF2N2O2
![7-Bromo-4-(3,4-dimethylbenzoyl)-5-phenyl-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one chemical structure, C24H21BrN2O2, CAS 533876-88-9](/s/CFFZQEVXAVDOSD-UHFFFAOYSA-N.svg)
7-Bromo-4-(3,4-dimethylbenzoyl)-5-phenyl-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one
CAS 533876-88-9C24H21BrN2O2
4-(4-tert-Butylbenzoyl)-7-chloro-5-(4-fluorophenyl)-3,5-dihydro-1H-1,4-benzodiazepin-2-one
CAS 533879-10-6C26H24ClFN2O2
7-Bromo-5-(4-fluorophenyl)-4-(2-methyl-3-nitrobenzoyl)-3,5-dihydro-1H-1,4-benzodiazepin-2-one
CAS 533876-92-5C23H17BrFN3O4
7-Bromo-4-(2-chloro-5-nitrobenzoyl)-5-(4-fluorophenyl)-3,5-dihydro-1H-1,4-benzodiazepin-2-one
CAS 533876-80-1C22H14BrClFN3O4
![4-(7-Bromo-2-oxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-4-carbonyl)-N,N-dimethylbenzenesulfonamide chemical structure, C24H22BrN3O4S, CAS 313262-76-9](/s/OXKSKBCDSGICJZ-UHFFFAOYSA-N.svg)
4-(7-Bromo-2-oxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-4-carbonyl)-N,N-dimethylbenzenesulfonamide
CAS 313262-76-9C24H22BrN3O4S
![4-(5-Bromo-2-chlorobenzoyl)-7-fluoro-5-phenyl-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one chemical structure, C22H15BrClFN2O2, CAS 533888-39-0](/s/YVQFFHYSWFZQHN-UHFFFAOYSA-N.svg)
4-(5-Bromo-2-chlorobenzoyl)-7-fluoro-5-phenyl-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one
CAS 533888-39-0C22H15BrClFN2O2
7-Bromo-4-(4-methoxybenzoyl)-5-phenyl-3,5-dihydro-1H-1,4-benzodiazepin-2-one
CAS 533876-46-9C23H19BrN2O3
![4-(2,5-Dichlorobenzoyl)-7-fluoro-5-phenyl-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one chemical structure, C22H15Cl2FN2O2, CAS 533888-30-1](/s/DKFRQYWTXOFTOF-UHFFFAOYSA-N.svg)
4-(2,5-Dichlorobenzoyl)-7-fluoro-5-phenyl-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one
CAS 533888-30-1C22H15Cl2FN2O2
![4-Benzoyl-5-(4-fluorophenyl)-7-methyl-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one chemical structure, C23H19FN2O2, CAS 533873-49-3](/s/BTWUXRFGACPOTQ-UHFFFAOYSA-N.svg)
4-Benzoyl-5-(4-fluorophenyl)-7-methyl-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one
CAS 533873-49-3C23H19FN2O2
7-Bromo-4-(4-ethoxybenzoyl)-5-phenyl-3,5-dihydro-1H-1,4-benzodiazepin-2-one
CAS 533876-49-2C24H21BrN2O3
7-Methyl-4-(2-methyl-3-nitrobenzoyl)-5-phenyl-3,5-dihydro-1H-1,4-benzodiazepin-2-one
CAS 533874-37-2C24H21N3O4
7-Methyl-4-(4-methyl-3-nitrobenzoyl)-5-phenyl-3,5-dihydro-1H-1,4-benzodiazepin-2-one
CAS 533874-40-7C24H21N3O4
4-(3,4-Diethoxybenzoyl)-7-fluoro-5-phenyl-3,5-dihydro-1H-1,4-benzodiazepin-2-one
CAS 533880-65-8C26H25FN2O4
5-(4-Fluorophenyl)-7-methyl-4-(2-nitrobenzoyl)-3,5-dihydro-1H-1,4-benzodiazepin-2-one
CAS 533873-80-2C23H18FN3O4
![7-Bromo-5-(4-fluorophenyl)-4-(2-iodobenzoyl)-1,3,4,5-tetrahydro-2H-benzo[e][1,4]diazepin-2-one chemical structure, C22H15BrFIN2O2, CAS 533876-30-1](/s/CFXZDEOFOAXVPQ-UHFFFAOYSA-N.svg)
7-Bromo-5-(4-fluorophenyl)-4-(2-iodobenzoyl)-1,3,4,5-tetrahydro-2H-benzo[e][1,4]diazepin-2-one
CAS 533876-30-1C22H15BrFIN2O2
![7-Methyl-4-(4-nitrobenzoyl)-5-phenyl-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one chemical structure, C23H19N3O4, CAS 312606-58-9](/s/NLQMJYZMTNDJPS-UHFFFAOYSA-N.svg)
7-Methyl-4-(4-nitrobenzoyl)-5-phenyl-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one
CAS 312606-58-9C23H19N3O4
4-(2,4-Dichlorobenzoyl)-7-fluoro-5-phenyl-3,5-dihydro-1H-1,4-benzodiazepin-2-one
CAS 533888-27-6C22H15Cl2FN2O2
![4-(4-Bromobenzoyl)-7-chloro-5-phenyl-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one chemical structure, C22H16BrClN2O2, CAS 391219-03-7](/s/UTGZHVJXSLYHFK-UHFFFAOYSA-N.svg)
4-(4-Bromobenzoyl)-7-chloro-5-phenyl-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one
CAS 391219-03-7C22H16BrClN2O2
![4-(4-Bromobenzoyl)-7-methyl-5-phenyl-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one chemical structure, C23H19BrN2O2, CAS 313684-00-3](/s/HCQNFCYRQZFALH-UHFFFAOYSA-N.svg)
4-(4-Bromobenzoyl)-7-methyl-5-phenyl-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one
CAS 313684-00-3C23H19BrN2O2
7-Chloro-4-(2-chloro-5-nitrobenzoyl)-5-(4-fluorophenyl)-3,5-dihydro-1H-1,4-benzodiazepin-2-one
CAS 533879-33-3C22H14Cl2FN3O4
- 7-Fluoro-4-(2-iodobenzoyl)-5-phenyl-3,5-dihydro-1H-1,4-benzodiazepin-2-one533887-90-0C22H16FIN2O2
- 7-Fluoro-5-(4-fluorophenyl)-4-(4-methyl-3-nitrobenzoyl)-3,5-dihydro-1H-1,4-benzodiazepin-2-one533888-60-7C23H17F2N3O4
- 7-Chloro-4-(2,3-dimethoxybenzoyl)-5-(4-fluorophenyl)-3,5-dihydro-1H-1,4-benzodiazepin-2-one533879-53-7C24H20ClFN2O4
- 4-(4-Chloro-3-nitrobenzoyl)-7-fluoro-5-(4-fluorophenyl)-3,5-dihydro-1H-1,4-benzodiazepin-2-one533888-51-6C22H14ClF2N3O4
- 7-Bromo-4-(2,4-dinitrobenzoyl)-5-phenyl-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one391219-00-4C22H15BrN4O6
- 4-(2-Iodobenzoyl)-7-methyl-5-phenyl-3,5-dihydro-1H-1,4-benzodiazepin-2-one533873-77-7C23H19IN2O2
- 5-(4-Fluorophenyl)-7-methyl-4-(4-nitrobenzoyl)-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one533873-84-6C23H18FN3O4
- 4-(3-Chlorobenzoyl)-7-fluoro-5-(4-fluorophenyl)-3,5-dihydro-1H-1,4-benzodiazepin-2-one533881-39-9C22H15ClF2N2O2
- 7-Bromo-4-(4-methyl-3-nitrobenzoyl)-5-phenyl-3,5-dihydro-1H-1,4-benzodiazepin-2-one533876-94-7C23H18BrN3O4
- 7-Bromo-4-(2-nitrobenzoyl)-5-phenyl-3,5-dihydro-1H-1,4-benzodiazepin-2-one313683-89-5C22H16BrN3O4
- 7-Chloro-4-(2-chloro-5-nitrobenzoyl)-5-phenyl-3,5-dihydro-1H-1,4-benzodiazepin-2-one533879-32-2C22H15Cl2N3O4
- 7-Chloro-5-(4-fluorophenyl)-4-(4-isopropoxybenzoyl)-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one533879-79-7C25H22ClFN2O3
- 7-Fluoro-4-(2-methyl-3-nitrobenzoyl)-5-phenyl-3,5-dihydro-1H-1,4-benzodiazepin-2-one533888-56-1C23H18FN3O4
- 7-Chloro-4-(2,4-dimethoxybenzoyl)-5-(4-fluorophenyl)-3,5-dihydro-1H-1,4-benzodiazepin-2-one6230-87-1C24H20ClFN2O4
- 7-Bromo-4-(4-ethoxybenzoyl)-5-(4-fluorophenyl)-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one533876-51-6C24H20BrFN2O3
- 7-Methyl-4-(2-methylbenzoyl)-5-phenyl-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one312606-48-7C24H22N2O2
- 7-Methyl-4-(3-methylbenzoyl)-5-phenyl-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one312606-49-8C24H22N2O2
- 4-(2-Bromobenzoyl)-7-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-2-one312606-52-3C23H19BrN2O2
- 4-(3-Bromobenzoyl)-7-methyl-5-phenyl-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one5627-99-6C23H19BrN2O2
- 4-Benzoyl-8-methyl-5-phenyl-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one2034604-75-4C23H20N2O2
- 7-Bromo-5-(2-chlorophenyl)-4-(2,3,4-trimethoxybenzoyl)-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-2-one1798718-01-0C25H22BrClN2O5