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Murcko scaffold

Ring system with 5 rings and 25 atoms

38 chemicals on CompoundList share this ring system.

Rings
5
Scaffold atoms
25
Chemicals
38
With full pages
13
Scaffold SMILES

O=C1CCCC2=C1C(c1ccccc1)C1=C(N2)c2ccccc2C1=O

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1CCCC2=C1C(c1ccccc1)C1=C(N2)c2ccccc2C1=O

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 38 of 38 chemicals

5-Butyl-7,7-dimethyl-10-phenyl-6,7,8,10-tetrahydro-5H-indeno[1,2-b]quinoline-9,11-dione chemical structure, C28H29NO2, CAS 3357-22-0
5-Butyl-7,7-dimethyl-10-phenyl-6,7,8,10-tetrahydro-5H-indeno[1,2-b]quinoline-9,11-dione
CAS 3357-22-0C28H29NO2
10-(3-Ethoxy-4-hydroxyphenyl)-7,7-dimethyl-6,7,8,10-tetrahydro-5H-indeno[1,2-b]quinoline-9,11-dione chemical structure, C26H25NO4, CAS 376618-40-5
10-(3-Ethoxy-4-hydroxyphenyl)-7,7-dimethyl-6,7,8,10-tetrahydro-5H-indeno[1,2-b]quinoline-9,11-dione
CAS 376618-40-5C26H25NO4
10-(4-Hydroxy-3-methoxyphenyl)-6,7,8,10-tetrahydro-5H-indeno[1,2-b]quinoline-9,11-dione chemical structure, C23H19NO4, CAS 372499-75-7
10-(4-Hydroxy-3-methoxyphenyl)-6,7,8,10-tetrahydro-5H-indeno[1,2-b]quinoline-9,11-dione
CAS 372499-75-7C23H19NO4
10-(3-Hydroxyphenyl)-7,7-dimethyl-6,7,8,10-tetrahydro-5H-indeno[1,2-b]quinoline-9,11-dione chemical structure, C24H21NO3, CAS 313269-12-4
10-(3-Hydroxyphenyl)-7,7-dimethyl-6,7,8,10-tetrahydro-5H-indeno[1,2-b]quinoline-9,11-dione
CAS 313269-12-4C24H21NO3
Methyl 4-(7,7-dimethyl-9,11-dioxo-6,7,8,9,10,11-hexahydro-5H-indeno[1,2-b]quinolin-10-yl)benzoate chemical structure, C26H23NO4, CAS 401815-61-0
Methyl 4-(7,7-dimethyl-9,11-dioxo-6,7,8,9,10,11-hexahydro-5H-indeno[1,2-b]quinolin-10-yl)benzoate
CAS 401815-61-0C26H23NO4
10-(2,3-Dimethoxyphenyl)-7,7-dimethyl-6,7,8,10-tetrahydro-5H-indeno[1,2-b]quinoline-9,11-dione chemical structure, C26H25NO4, CAS 377056-41-2
10-(2,3-Dimethoxyphenyl)-7,7-dimethyl-6,7,8,10-tetrahydro-5H-indeno[1,2-b]quinoline-9,11-dione
CAS 377056-41-2C26H25NO4
Methyl 4-(9,11-dioxo-6,7,8,9,10,11-hexahydro-5H-indeno[1,2-b]quinolin-10-yl)benzoate chemical structure, C24H19NO4, CAS 431907-64-1
Methyl 4-(9,11-dioxo-6,7,8,9,10,11-hexahydro-5H-indeno[1,2-b]quinolin-10-yl)benzoate
CAS 431907-64-1C24H19NO4
7,7-Dimethyl-10-[4-(propan-2-yl)phenyl]-6,7,8,10-tetrahydro-5H-indeno[1,2-b]quinoline-9,11-dione chemical structure, C27H27NO2, CAS 431937-38-1
7,7-Dimethyl-10-[4-(propan-2-yl)phenyl]-6,7,8,10-tetrahydro-5H-indeno[1,2-b]quinoline-9,11-dione
CAS 431937-38-1C27H27NO2
10-(4-Ethoxyphenyl)-6,7,8,10-tetrahydro-5H-indeno[1,2-b]quinoline-9,11-dione chemical structure, C24H21NO3, CAS 431983-44-7
10-(4-Ethoxyphenyl)-6,7,8,10-tetrahydro-5H-indeno[1,2-b]quinoline-9,11-dione
CAS 431983-44-7C24H21NO3
10-(3-Methoxyphenyl)-7,7-dimethyl-6,7,8,10-tetrahydro-5H-indeno[1,2-b]quinoline-9,11-dione chemical structure, C25H23NO3, CAS 371137-16-5
10-(3-Methoxyphenyl)-7,7-dimethyl-6,7,8,10-tetrahydro-5H-indeno[1,2-b]quinoline-9,11-dione
CAS 371137-16-5C25H23NO3
10-(4-Hydroxyphenyl)-7,7-dimethyl-6,7,8,10-tetrahydro-5H-indeno[1,2-b]quinoline-9,11-dione chemical structure, C24H21NO3, CAS 332938-24-6
10-(4-Hydroxyphenyl)-7,7-dimethyl-6,7,8,10-tetrahydro-5H-indeno[1,2-b]quinoline-9,11-dione
CAS 332938-24-6C24H21NO3
4-(7,7-Dimethyl-9,11-dioxo-6,7,8,9,10,11-hexahydro-5H-indeno[1,2-b]quinolin-10-yl)phenyl propanoate chemical structure, C27H25NO4, CAS 443735-85-1
4-(7,7-Dimethyl-9,11-dioxo-6,7,8,9,10,11-hexahydro-5H-indeno[1,2-b]quinolin-10-yl)phenyl propanoate
CAS 443735-85-1C27H25NO4
5-Butyl-10-(4-nitrophenyl)-6,7,8,10-tetrahydro-5H-indeno[1,2-b]quinoline-9,11-dione chemical structure, C26H24N2O4, CAS 511309-44-7
5-Butyl-10-(4-nitrophenyl)-6,7,8,10-tetrahydro-5H-indeno[1,2-b]quinoline-9,11-dione
CAS 511309-44-7C26H24N2O4
7,7-Dimethyl-10-[4-(trifluoromethyl)phenyl]-6,7,8,10-tetrahydro-5H-indeno[1,2-b]quinoline-9,11-dione chemical structure, C25H20F3NO2, CAS 689761-09-9
7,7-Dimethyl-10-[4-(trifluoromethyl)phenyl]-6,7,8,10-tetrahydro-5H-indeno[1,2-b]quinoline-9,11-dione
CAS 689761-09-9C25H20F3NO2
10-[4-(Trifluoromethyl)phenyl]-6,7,8,10-tetrahydro-5H-indeno[1,2-b]quinoline-9,11-dione chemical structure, C23H16F3NO2, CAS 650592-85-1
10-[4-(Trifluoromethyl)phenyl]-6,7,8,10-tetrahydro-5H-indeno[1,2-b]quinoline-9,11-dione
CAS 650592-85-1C23H16F3NO2
7,7-Dimethyl-10-[2-(trifluoromethyl)phenyl]-5,6,8,10-tetrahydroindeno[1,2-b]quinoline-9,11-dione chemical structure, C25H20F3NO2, CAS 694516-27-3
7,7-Dimethyl-10-[2-(trifluoromethyl)phenyl]-5,6,8,10-tetrahydroindeno[1,2-b]quinoline-9,11-dione
CAS 694516-27-3C25H20F3NO2
10-[4-(Methylsulfanyl)phenyl]-6,7,8,10-tetrahydro-5H-indeno[1,2-b]quinoline-9,11-dione chemical structure, C23H19NO2S, CAS 695172-51-1
10-[4-(Methylsulfanyl)phenyl]-6,7,8,10-tetrahydro-5H-indeno[1,2-b]quinoline-9,11-dione
CAS 695172-51-1C23H19NO2S
10-(2,3,4-Trimethoxyphenyl)-6,7,8,10-tetrahydro-5H-indeno[1,2-b]quinoline-9,11-dione chemical structure, C25H23NO5, CAS 669753-40-6
10-(2,3,4-Trimethoxyphenyl)-6,7,8,10-tetrahydro-5H-indeno[1,2-b]quinoline-9,11-dione
CAS 669753-40-6C25H23NO5
10-(4-Ethylphenyl)-7,7-dimethyl-6,7,8,10-tetrahydro-5H-indeno[1,2-b]quinoline-9,11-dione chemical structure, C26H25NO2, CAS 669740-13-0
10-(4-Ethylphenyl)-7,7-dimethyl-6,7,8,10-tetrahydro-5H-indeno[1,2-b]quinoline-9,11-dione
CAS 669740-13-0C26H25NO2
10-(4-Fluorophenyl)-7,7-dimethyl-5-propyl-6,7,8,10-tetrahydro-5H-indeno[1,2-b]quinoline-9,11-dione chemical structure, C27H26FNO2, CAS 669725-65-9
10-(4-Fluorophenyl)-7,7-dimethyl-5-propyl-6,7,8,10-tetrahydro-5H-indeno[1,2-b]quinoline-9,11-dione
CAS 669725-65-9C27H26FNO2
10-(4-Butylphenyl)-7,7-dimethyl-6,7,8,10-tetrahydro-5H-indeno[1,2-b]quinoline-9,11-dione chemical structure, C28H29NO2, CAS 337499-04-4
10-(4-Butylphenyl)-7,7-dimethyl-6,7,8,10-tetrahydro-5H-indeno[1,2-b]quinoline-9,11-dione
CAS 337499-04-4C28H29NO2
10-(2,5-Dimethoxyphenyl)-7,7-dimethyl-6,7,8,10-tetrahydro-5H-indeno[1,2-b]quinoline-9,11-dione chemical structure, C26H25NO4, CAS 387383-54-2
10-(2,5-Dimethoxyphenyl)-7,7-dimethyl-6,7,8,10-tetrahydro-5H-indeno[1,2-b]quinoline-9,11-dione
CAS 387383-54-2C26H25NO4
10-(4-Hydroxy-3-methoxyphenyl)-7,7-dimethyl-6,7,8,10-tetrahydro-5H-indeno[1,2-b]quinoline-9,11-dione chemical structure, C25H23NO4, CAS 103778-55-8
10-(4-Hydroxy-3-methoxyphenyl)-7,7-dimethyl-6,7,8,10-tetrahydro-5H-indeno[1,2-b]quinoline-9,11-dione
CAS 103778-55-8C25H23NO4
7,7-Dimethyl-10-(3,4,5-trimethoxyphenyl)-6,7,8,10-tetrahydro-5H-indeno[1,2-b]quinoline-9,11-dione chemical structure, C27H27NO5, CAS 372977-43-0
7,7-Dimethyl-10-(3,4,5-trimethoxyphenyl)-6,7,8,10-tetrahydro-5H-indeno[1,2-b]quinoline-9,11-dione
CAS 372977-43-0C27H27NO5