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Murcko scaffold

1,4-Diazepan-2-one scaffold

73 chemicals on CompoundList share this ring system.

Rings
1
Scaffold atoms
8
Chemicals
73
With full pages
14
Scaffold SMILES

O=C1CNCCCN1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1,4-Diazepan-2-one page
Murcko scaffold O=C1CNCCCN1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 73 chemicals

4-Methyl-1,4-diazepan-2-one chemical structure, C6H12N2O, CAS 24286-84-8
4-Methyl-1,4-diazepan-2-one
CAS 24286-84-8C6H12N2O
3,4-Dimethyl-1,4-diazepan-2-one chemical structure, C7H14N2O, CAS 67744-41-6
3,4-Dimethyl-1,4-diazepan-2-one
CAS 67744-41-6C7H14N2O
6,6-Dimethyl-1,4-diazepan-2-one chemical structure, C7H14N2O, CAS 67744-44-9
6,6-Dimethyl-1,4-diazepan-2-one
CAS 67744-44-9C7H14N2O
1,4-Diazepan-2-one chemical structure, C5H10N2O, CAS 99822-50-1
1,4-Diazepan-2-one
CAS 99822-50-1C5H10N2O
Hexahydro-3-(2-methylpropyl)-2H-1,4-diazepin-2-one chemical structure, C9H18N2O, CAS 78551-31-2
Hexahydro-3-(2-methylpropyl)-2H-1,4-diazepin-2-one
CAS 78551-31-2C9H18N2O
4-(2-Hydroxyethyl)-1,4-diazepan-2-one chemical structure, C7H14N2O2, CAS 122734-19-4
4-(2-Hydroxyethyl)-1,4-diazepan-2-one
CAS 122734-19-4C7H14N2O2
(S)-3-Methyl-1,4-diazepan-2-one chemical structure, C6H12N2O, CAS 128427-25-8
(S)-3-Methyl-1,4-diazepan-2-one
CAS 128427-25-8C6H12N2O
3-Methyl-1,4-diazepan-2-one chemical structure, C6H12N2O, CAS 217973-05-2
3-Methyl-1,4-diazepan-2-one
CAS 217973-05-2C6H12N2O
1-Methyl-1,4-diazepan-2-one chemical structure, C6H12N2O, CAS 60565-89-1
1-Methyl-1,4-diazepan-2-one
CAS 60565-89-1C6H12N2O
tert-Butyl Hexahydro-4-methyl-3-oxo-1H-1,4-diazepine-1-carboxylate chemical structure, C11H20N2O3, CAS 1391743-75-1
tert-Butyl Hexahydro-4-methyl-3-oxo-1H-1,4-diazepine-1-carboxylate
CAS 1391743-75-1C11H20N2O3
tert-Butyl 3-oxo-1,4-diazepane-1-carboxylate chemical structure, C10H18N2O3, CAS 179686-38-5
tert-Butyl 3-oxo-1,4-diazepane-1-carboxylate
CAS 179686-38-5C10H18N2O3
1-Methyl-1,4-diazepan-2-one hydrochloride chemical structure, C6H13ClN2O, CAS 685859-01-2
1-Methyl-1,4-diazepan-2-one hydrochloride
CAS 685859-01-2C6H13ClN2O
3-Ethyl-1,4-diazepan-2-one chemical structure, C7H14N2O, CAS 808737-30-6
3-Ethyl-1,4-diazepan-2-one
CAS 808737-30-6C7H14N2O
1,4-Diazepan-2-one hydrochloride chemical structure, C5H11ClN2O, CAS 1056010-05-9
1,4-Diazepan-2-one hydrochloride
CAS 1056010-05-9C5H11ClN2O
3-(2,2,2-Trifluoroethyl)-1,4-diazepan-2-one chemical structure, C7H11F3N2O, CAS 892144-11-5
3-(2,2,2-Trifluoroethyl)-1,4-diazepan-2-one
CAS 892144-11-5C7H11F3N2O
Methyl 3-oxo-1,4-diazepane-1-carboxylate chemical structure, C7H12N2O3, CAS 1258649-98-7
Methyl 3-oxo-1,4-diazepane-1-carboxylate
CAS 1258649-98-7C7H12N2O3
tert-Butyl 5-methyl-3-oxo-1,4-diazepane-1-carboxylate chemical structure, C11H20N2O3, CAS 179686-61-4
tert-Butyl 5-methyl-3-oxo-1,4-diazepane-1-carboxylate
CAS 179686-61-4C11H20N2O3
(R)-3-Methyl-1,4-diazepan-2-one chemical structure, C6H12N2O, CAS 790207-81-7
(R)-3-Methyl-1,4-diazepan-2-one
CAS 790207-81-7C6H12N2O
(3R)-3-Ethyl-1,4-diazepan-2-one chemical structure, C7H14N2O, CAS 922178-62-9
(3R)-3-Ethyl-1,4-diazepan-2-one
CAS 922178-62-9C7H14N2O
Ethyl 3-oxo-1,4-diazepane-1-carboxylate chemical structure, C8H14N2O3, CAS 1484919-10-9
Ethyl 3-oxo-1,4-diazepane-1-carboxylate
CAS 1484919-10-9C8H14N2O3
1-Propyl-1,4-diazepan-2-one chemical structure, C8H16N2O, CAS 155595-81-6
1-Propyl-1,4-diazepan-2-one
CAS 155595-81-6C8H16N2O
1-(2-Methoxyethyl)-1,4-diazepan-2-one chemical structure, C8H16N2O2, CAS 1513297-05-6
1-(2-Methoxyethyl)-1,4-diazepan-2-one
CAS 1513297-05-6C8H16N2O2
1-Ethyl-1,4-diazepan-2-one chemical structure, C7H14N2O, CAS 1543092-05-2
1-Ethyl-1,4-diazepan-2-one
CAS 1543092-05-2C7H14N2O
(R)-4-Boc-3-methyl-1,4-diazepan-2-one chemical structure, C11H20N2O3, CAS 685858-98-4
(R)-4-Boc-3-methyl-1,4-diazepan-2-one
CAS 685858-98-4C11H20N2O3