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Murcko scaffold

Ring system with 4 rings and 31 atoms

10 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
31
Chemicals
10
With full pages
6
Scaffold SMILES

O=C1C(=Cc2ccccc2)CN(C(=O)CCc2ccccc2)CC1=Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1C(=Cc2ccccc2)CN(C(=O)CCc2ccccc2)CC1=Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 10 of 10 chemicals

(3E,5E)-1-[(2S)-2-Amino-3-phenylpropanoyl]-3,5-bis[(4-nitrophenyl)methylidene]piperidin-4-one chemical structure, C28H24N4O6, CAS 2649154-64-1
(3E,5E)-1-[(2S)-2-Amino-3-phenylpropanoyl]-3,5-bis[(4-nitrophenyl)methylidene]piperidin-4-one
CAS 2649154-64-1C28H24N4O6
1-(L-Phenylalanyl)-3,5-bis((E)-3,4-dichlorobenzylidene)piperidin-4-one hydrochloride chemical structure, C28H23Cl5N2O2
1-(L-Phenylalanyl)-3,5-bis((E)-3,4-dichlorobenzylidene)piperidin-4-one hydrochloride
C28H23Cl5N2O2
1-(L-Phenylalanyl)-3,5-bis(3,4-dichlorobenzylidene)piperidin-4-one hydrochloride chemical structure, C28H23Cl5N2O2, CAS 1617495-03-0
1-(L-Phenylalanyl)-3,5-bis(3,4-dichlorobenzylidene)piperidin-4-one hydrochloride
CAS 1617495-03-0C28H23Cl5N2O2
1-(L-Phenylalanyl)-3,5-bis(3,4-dichlorobenzylidene)piperidin-4-one chemical structure, C28H22Cl4N2O2, CAS 1617572-02-7
1-(L-Phenylalanyl)-3,5-bis(3,4-dichlorobenzylidene)piperidin-4-one
CAS 1617572-02-7C28H22Cl4N2O2
(3Z)-1-[(2S)-2-Amino-3-phenylpropanoyl]-3,5-bis[(3,4-dichlorophenyl)methylidene]piperidin-4-one, hydrochloride chemical structure, C28H23Cl5N2O2
(3Z)-1-[(2S)-2-Amino-3-phenylpropanoyl]-3,5-bis[(3,4-dichlorophenyl)methylidene]piperidin-4-one, hydrochloride
C28H23Cl5N2O2
1-(2-Amino-3-phenylpropanoyl)-3,5-bis[(3,4-dichlorophenyl)methylidene]piperidin-4-one, hydrochloride chemical structure, C28H23Cl5N2O2
1-(2-Amino-3-phenylpropanoyl)-3,5-bis[(3,4-dichlorophenyl)methylidene]piperidin-4-one, hydrochloride
C28H23Cl5N2O2
(3E,5E)-1-[(2S)-2-[2-(2-Aminoethoxy)ethylamino]-3-phenylpropanoyl]-3,5-bis[(3,4-dichlorophenyl)methylidene]piperidin-4-one chemical structure, C32H31Cl4N3O3, CAS 2375455-68-6
(3E,5E)-1-[(2S)-2-[2-(2-Aminoethoxy)ethylamino]-3-phenylpropanoyl]-3,5-bis[(3,4-dichlorophenyl)methylidene]piperidin-4-one
CAS 2375455-68-6C32H31Cl4N3O3
Orb1303892 chemical structure, C30H25ClN4O7, CAS 2649154-57-2
Orb1303892
CAS 2649154-57-2C30H25ClN4O7
1-[(2S)-2-Amino-3-phenylpropanoyl]-3,5-bis[(3,4-dichlorophenyl)methylidene]piperidin-4-one, hydrochloride chemical structure, C28H23Cl5N2O2
1-[(2S)-2-Amino-3-phenylpropanoyl]-3,5-bis[(3,4-dichlorophenyl)methylidene]piperidin-4-one, hydrochloride
C28H23Cl5N2O2
(3Z,5E)-1-[(2S)-2-Amino-3-phenylpropanoyl]-3,5-bis[(3,4-dichlorophenyl)methylidene]piperidin-4-one, hydrochloride chemical structure, C28H23Cl5N2O2
(3Z,5E)-1-[(2S)-2-Amino-3-phenylpropanoyl]-3,5-bis[(3,4-dichlorophenyl)methylidene]piperidin-4-one, hydrochloride
C28H23Cl5N2O2