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Murcko scaffold

Ring system with 3 rings and 29 atoms

21 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
29
Chemicals
21
With full pages
3
Scaffold SMILES

O=C(CCCN1C(=O)C(=Cc2ccccc2)SC1=S)NNC(=O)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CCCN1C(=O)C(=Cc2ccccc2)SC1=S)NNC(=O)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 21 of 21 chemicals

N'-{4-[(5Z)-5-[(3-Bromophenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanoyl}-2-hydroxybenzohydrazide chemical structure, C21H18BrN3O4S2, CAS 315236-01-2
N'-{4-[(5Z)-5-[(3-Bromophenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanoyl}-2-hydroxybenzohydrazide
CAS 315236-01-2C21H18BrN3O4S2
4-Chloro-N'-{4-[(5Z)-5-(4-methylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]butanoyl}benzohydrazide chemical structure, C22H20ClN3O3S2, CAS 380584-73-6
4-Chloro-N'-{4-[(5Z)-5-(4-methylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]butanoyl}benzohydrazide
CAS 380584-73-6C22H20ClN3O3S2
3-Chloro-N'-{4-[(5Z)-5-(2-chlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]butanoyl}benzohydrazide chemical structure, C21H17Cl2N3O3S2, CAS 381176-93-8
3-Chloro-N'-{4-[(5Z)-5-(2-chlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]butanoyl}benzohydrazide
CAS 381176-93-8C21H17Cl2N3O3S2
2-Chloro-N'-{4-[(5Z)-5-(2-chlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]butanoyl}benzohydrazide chemical structure, C21H17Cl2N3O3S2, CAS 1164538-68-4
2-Chloro-N'-{4-[(5Z)-5-(2-chlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]butanoyl}benzohydrazide
CAS 1164538-68-4C21H17Cl2N3O3S2
2-Bromo-N'-{4-[(5Z)-5-(4-methylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]butanoyl}benzohydrazide chemical structure, C22H20BrN3O3S2, CAS 380903-68-4
2-Bromo-N'-{4-[(5Z)-5-(4-methylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]butanoyl}benzohydrazide
CAS 380903-68-4C22H20BrN3O3S2
2-Bromo-N'-{4-[(5Z)-5-(2-chlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]butanoyl}benzohydrazide chemical structure, C21H17BrClN3O3S2, CAS 380882-25-7
2-Bromo-N'-{4-[(5Z)-5-(2-chlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]butanoyl}benzohydrazide
CAS 380882-25-7C21H17BrClN3O3S2
2,4-Dichloro-N'-{4-[(5Z)-5-(4-methylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]butanoyl}benzohydrazide chemical structure, C22H19Cl2N3O3S2, CAS 380594-90-1
2,4-Dichloro-N'-{4-[(5Z)-5-(4-methylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]butanoyl}benzohydrazide
CAS 380594-90-1C22H19Cl2N3O3S2
4-Chloro-benzoic acid N'-(4-{5-[1-(2-chloro-phenyl)-meth-(Z)-ylidene]-4-oxo-2-thioxo-thiazolidin-3-yl}-butyryl)-hydrazide chemical structure, C21H17Cl2N3O3S2, CAS 381716-70-7
4-Chloro-benzoic acid N'-(4-{5-[1-(2-chloro-phenyl)-meth-(Z)-ylidene]-4-oxo-2-thioxo-thiazolidin-3-yl}-butyryl)-hydrazide
CAS 381716-70-7C21H17Cl2N3O3S2
2,4-Dichloro-N'-{4-[(5Z)-5-(2-chlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]butanoyl}benzohydrazide chemical structure, C21H16Cl3N3O3S2, CAS 380880-31-9
2,4-Dichloro-N'-{4-[(5Z)-5-(2-chlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]butanoyl}benzohydrazide
CAS 380880-31-9C21H16Cl3N3O3S2
5-[(4-Methylphenyl)methylene]-4-oxo-2-thioxo-3-thiazolidinebutanoic acid 2-(4-methylbenzoyl)hydrazide chemical structure, C23H23N3O3S2, CAS 380583-58-4
5-[(4-Methylphenyl)methylene]-4-oxo-2-thioxo-3-thiazolidinebutanoic acid 2-(4-methylbenzoyl)hydrazide
CAS 380583-58-4C23H23N3O3S2
2-Hydroxy-N'-[4-[(5Z)-5-[(4-methoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanoyl]benzohydrazide chemical structure, C22H21N3O5S2, CAS 307526-94-9
2-Hydroxy-N'-[4-[(5Z)-5-[(4-methoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanoyl]benzohydrazide
CAS 307526-94-9C22H21N3O5S2
N'-{4-[(5Z)-5-(4-ethylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]butanoyl}-2-hydroxybenzohydrazide chemical structure, C23H23N3O4S2, CAS 315243-82-4
N'-{4-[(5Z)-5-(4-ethylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]butanoyl}-2-hydroxybenzohydrazide
CAS 315243-82-4C23H23N3O4S2
N'-{4-[(5Z)-5-(4-ethylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]butanoyl}-3-hydroxybenzohydrazide chemical structure, C23H23N3O4S2, CAS 315243-84-6
N'-{4-[(5Z)-5-(4-ethylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]butanoyl}-3-hydroxybenzohydrazide
CAS 315243-84-6C23H23N3O4S2
3-Chloro-N'-{4-[(5Z)-5-(4-ethylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]butanoyl}benzohydrazide chemical structure, C23H22ClN3O3S2, CAS 315243-89-1
3-Chloro-N'-{4-[(5Z)-5-(4-ethylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]butanoyl}benzohydrazide
CAS 315243-89-1C23H22ClN3O3S2
2-Chloro-N'-{4-[(5Z)-5-(4-ethylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]butanoyl}benzohydrazide chemical structure, C23H22ClN3O3S2, CAS 315243-88-0
2-Chloro-N'-{4-[(5Z)-5-(4-ethylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]butanoyl}benzohydrazide
CAS 315243-88-0C23H22ClN3O3S2
4-Bromo-N'-{4-[(5Z)-5-(4-ethylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]butanoyl}benzohydrazide chemical structure, C23H22BrN3O3S2, CAS 315243-93-7
4-Bromo-N'-{4-[(5Z)-5-(4-ethylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]butanoyl}benzohydrazide
CAS 315243-93-7C23H22BrN3O3S2
N'-{4-[(5Z)-5-(4-ethylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]butanoyl}-4-methylbenzohydrazide chemical structure, C24H25N3O3S2, CAS 315243-81-3
N'-{4-[(5Z)-5-(4-ethylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]butanoyl}-4-methylbenzohydrazide
CAS 315243-81-3C24H25N3O3S2
4-Chloro-N'-{4-[(5Z)-5-(4-ethylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]butanoyl}benzohydrazide chemical structure, C23H22ClN3O3S2, CAS 315243-90-4
4-Chloro-N'-{4-[(5Z)-5-(4-ethylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]butanoyl}benzohydrazide
CAS 315243-90-4C23H22ClN3O3S2
N'-{4-[(5Z)-5-(4-ethylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]butanoyl}-4-fluorobenzohydrazide chemical structure, C23H22FN3O3S2, CAS 315243-94-8
N'-{4-[(5Z)-5-(4-ethylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]butanoyl}-4-fluorobenzohydrazide
CAS 315243-94-8C23H22FN3O3S2
N'-{4-[(5Z)-5-(4-ethylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]butanoyl}-4-hydroxybenzohydrazide chemical structure, C23H23N3O4S2, CAS 315243-83-5
N'-{4-[(5Z)-5-(4-ethylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]butanoyl}-4-hydroxybenzohydrazide
CAS 315243-83-5C23H23N3O4S2
(E)-N'-(4-(5-(3-Methoxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)butanoyl)-3-nitrobenzohydrazide chemical structure, C22H20N4O6S2, CAS 476667-96-6
(E)-N'-(4-(5-(3-Methoxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)butanoyl)-3-nitrobenzohydrazide
CAS 476667-96-6C22H20N4O6S2