Murcko scaffold
Ring system with 4 rings and 24 atoms
17 chemicals on CompoundList share this ring system.
- Rings
- 4
- Scaffold atoms
- 24
- Chemicals
- 17
- With full pages
- 7
Scaffold SMILES
O=C1CC2CCC1(CS(=O)(=O)N1CCN(c3ccccc3)CC1)C2
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 17 of 17 chemicals
![1-(((4-(2-Methoxyphenyl)piperazinyl)sulfonyl)methyl)7,7-dimethylbicyclo[2.2.1]heptan-2-one chemical structure, C21H30N2O4S, CAS 1274904-30-1](/s/YBEVARNSCIXTOZ-IIBYNOLFSA-N.svg)
1-(((4-(2-Methoxyphenyl)piperazinyl)sulfonyl)methyl)7,7-dimethylbicyclo[2.2.1]heptan-2-one
CAS 1274904-30-1C21H30N2O4S
![7,7-Dimethyl-1-(((4-(3-(trifluoromethyl)phenyl)piperazinyl)sulfonyl)methyl)bicyclo[2.2.1]heptan-2-one chemical structure, C21H27F3N2O3S, CAS 920527-56-6](/s/HJLLIXPXDJITJH-FOIQADDNSA-N.svg)
7,7-Dimethyl-1-(((4-(3-(trifluoromethyl)phenyl)piperazinyl)sulfonyl)methyl)bicyclo[2.2.1]heptan-2-one
CAS 920527-56-6C21H27F3N2O3S
![1-({[4-(2,5-Dimethylphenyl)-1-piperazinyl]sulfonyl}methyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-one chemical structure, C22H32N2O3S, CAS 825608-80-8](/s/DJYBGPZXBLFKCU-UHFFFAOYSA-N.svg)
1-({[4-(2,5-Dimethylphenyl)-1-piperazinyl]sulfonyl}methyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-one
CAS 825608-80-8C22H32N2O3S
![4-[[4-(3-Chloro-2-methylphenyl)piperazin-1-yl]sulfonylmethyl]-7,7-dimethylbicyclo[2.2.1]heptan-3-one chemical structure, C21H29ClN2O3S, CAS 825608-90-0](/s/VEJWGLJWBOKRQS-UHFFFAOYSA-N.svg)
4-[[4-(3-Chloro-2-methylphenyl)piperazin-1-yl]sulfonylmethyl]-7,7-dimethylbicyclo[2.2.1]heptan-3-one
CAS 825608-90-0C21H29ClN2O3S
![1-({[4-(4-Methoxyphenyl)-1-piperazinyl]sulfonyl}methyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-one chemical structure, C21H30N2O4S, CAS 459822-54-9](/s/XXLAEFAPMKKSHM-UHFFFAOYSA-N.svg)
1-({[4-(4-Methoxyphenyl)-1-piperazinyl]sulfonyl}methyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-one
CAS 459822-54-9C21H30N2O4S
![1-({[4-(2,5-Dichlorophenyl)piperazin-1-yl]sulfonyl}methyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-one chemical structure, C20H26Cl2N2O3S, CAS 728017-21-8](/s/SXEPUCNUHGLCHC-UHFFFAOYSA-N.svg)
1-({[4-(2,5-Dichlorophenyl)piperazin-1-yl]sulfonyl}methyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-one
CAS 728017-21-8C20H26Cl2N2O3S
![1-({[4-(4-Fluorophenyl)-1-piperazinyl]sulfonyl}methyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-one chemical structure, C20H27FN2O3S, CAS 459822-55-0](/s/VYPMSMQOKWIUFB-UHFFFAOYSA-N.svg)
1-({[4-(4-Fluorophenyl)-1-piperazinyl]sulfonyl}methyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-one
CAS 459822-55-0C20H27FN2O3S
![7,7-Dimethyl-1-(4-o-tolyl-piperazine-1-sulfonylmethyl)-bicyclo[2.2.1]heptan-2-one chemical structure, C21H30N2O3S, CAS 161972-24-3](/s/TZHZUCUJVSBWEW-UHFFFAOYSA-N.svg)
7,7-Dimethyl-1-(4-o-tolyl-piperazine-1-sulfonylmethyl)-bicyclo[2.2.1]heptan-2-one
CAS 161972-24-3C21H30N2O3S
![1-({[4-(4-Ethylphenyl)piperazin-1-yl]sulfonyl}methyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-one chemical structure, C22H32N2O3S, CAS 839685-86-8](/s/UTHJNXUAYHPAKD-UHFFFAOYSA-N.svg)
1-({[4-(4-Ethylphenyl)piperazin-1-yl]sulfonyl}methyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-one
CAS 839685-86-8C22H32N2O3S
![1-({[4-(2-Methoxyphenyl)piperazin-1-yl]sulfonyl}methyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-one chemical structure, C21H30N2O4S, CAS 315692-82-1](/s/YBEVARNSCIXTOZ-UHFFFAOYSA-N.svg)
1-({[4-(2-Methoxyphenyl)piperazin-1-yl]sulfonyl}methyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-one
CAS 315692-82-1C21H30N2O4S
![1-(((4-(5-Chloro-2-methylphenyl)piperazinyl)sulfonyl)methyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-one chemical structure, C21H29ClN2O3S, CAS 1022130-08-0](/s/AFRMFWLXYPQQJG-UHFFFAOYSA-N.svg)
1-(((4-(5-Chloro-2-methylphenyl)piperazinyl)sulfonyl)methyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-one
CAS 1022130-08-0C21H29ClN2O3S
![7,7-Dimethyl-1-[({4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}sulfonyl)methyl]bicyclo[2.2.1]heptan-2-one chemical structure, C21H27F3N2O3S, CAS 315692-83-2](/s/HJLLIXPXDJITJH-UHFFFAOYSA-N.svg)
7,7-Dimethyl-1-[({4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}sulfonyl)methyl]bicyclo[2.2.1]heptan-2-one
CAS 315692-83-2C21H27F3N2O3S
![(4R)-1-(((4-(2-Fluorophenyl)piperazin-1-yl)sulfonyl)methyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-one chemical structure, C20H27FN2O3S, CAS 569651-70-3](/s/BPXNLJUCFQEUQC-UHFFFAOYSA-N.svg)
(4R)-1-(((4-(2-Fluorophenyl)piperazin-1-yl)sulfonyl)methyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-one
CAS 569651-70-3C20H27FN2O3S
![4-[[4-(3-Chloro-4-methylphenyl)piperazin-1-yl]sulfonylmethyl]-7,7-dimethylbicyclo[2.2.1]heptan-3-one chemical structure, C21H29ClN2O3S, CAS 728017-19-4](/s/IQDOZLCPRLZJSR-UHFFFAOYSA-N.svg)
4-[[4-(3-Chloro-4-methylphenyl)piperazin-1-yl]sulfonylmethyl]-7,7-dimethylbicyclo[2.2.1]heptan-3-one
CAS 728017-19-4C21H29ClN2O3S
![1-({[4-(2,6-Dimethylphenyl)piperazin-1-yl]sulfonyl}methyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-one chemical structure, C22H32N2O3S, CAS 879053-00-6](/s/AESDDWZZXFHKGZ-UHFFFAOYSA-N.svg)
1-({[4-(2,6-Dimethylphenyl)piperazin-1-yl]sulfonyl}methyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-one
CAS 879053-00-6C22H32N2O3S
![1-({[4-(3-Chlorophenyl)piperazin-1-yl]sulfonyl}methyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-one chemical structure, C20H27ClN2O3S, CAS 1087640-70-7](/s/VFVJBXOIGABCAW-UHFFFAOYSA-N.svg)
1-({[4-(3-Chlorophenyl)piperazin-1-yl]sulfonyl}methyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-one
CAS 1087640-70-7C20H27ClN2O3S
![1-(((4-(5-Chloro-2-methylphenyl)piperazinyl)sulfonyl)methyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-one chemical structure, C21H29ClN2O3S, CAS 1274892-09-9](/s/AFRMFWLXYPQQJG-IIBYNOLFSA-N.svg)
1-(((4-(5-Chloro-2-methylphenyl)piperazinyl)sulfonyl)methyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-one
CAS 1274892-09-9C21H29ClN2O3S
Related scaffolds
Same ring framework with different atoms or bond orders
