Murcko scaffold
5H,6H,7H,8H-(1,2,4)Triazolo(1,5-a)pyrazine scaffold
75 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 9
- Chemicals
- 75
- With full pages
- 5
Scaffold SMILES
c1nc2n(n1)CCNC2
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 75 chemicals
5H,6H,7H,8H-(1,2,4)Triazolo(1,5-a)pyrazine
CAS 233278-56-3C5H8N4
2-Methyl-5H,6H,7H,8H-(1,2,4)triazolo(1,5-a)pyrazine
CAS 914654-92-5C6H10N4
![7-Methyl-6,8-dihydro-5H-[1,2,4]triazolo[1,5-a]pyrazine chemical structure, C6H10N4, CAS 1877615-80-9](/s/JXSVAZTXBFQZDZ-UHFFFAOYSA-N.svg)
7-Methyl-6,8-dihydro-5H-[1,2,4]triazolo[1,5-a]pyrazine
CAS 1877615-80-9C6H10N4
![tert-Butyl 5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazine-7(8H)-carboxylate chemical structure, C10H16N4O2, CAS 1824150-16-4](/s/QEXKSFDJUXVRIA-UHFFFAOYSA-N.svg)
tert-Butyl 5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazine-7(8H)-carboxylate
CAS 1824150-16-4C10H16N4O2
![7-Ethyl-6,8-dihydro-5H-[1,2,4]triazolo[1,5-a]pyrazine chemical structure, C7H12N4, CAS 1882812-78-3](/s/YQWVBYJNTIQSEB-UHFFFAOYSA-N.svg)
7-Ethyl-6,8-dihydro-5H-[1,2,4]triazolo[1,5-a]pyrazine
CAS 1882812-78-3C7H12N4
![5,6,7,8-Tetrahydro-2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrazine chemical structure, C6H7F3N4, CAS 681249-57-0](/s/GYIDIDSTOZMTCM-UHFFFAOYSA-N.svg)
5,6,7,8-Tetrahydro-2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrazine
CAS 681249-57-0C6H7F3N4
![7-(tert-Butoxycarbonyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine-2-carboxylic acid chemical structure, C11H16N4O4, CAS 1208928-62-4](/s/WNYYPNLLUQTOJU-UHFFFAOYSA-N.svg)
7-(tert-Butoxycarbonyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine-2-carboxylic acid
CAS 1208928-62-4C11H16N4O4
![tert-Butyl 2-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazine-7(8H)-carboxylate chemical structure, C11H15F3N4O2, CAS 681249-59-2](/s/DMGHMNCRYGWVFF-UHFFFAOYSA-N.svg)
tert-Butyl 2-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazine-7(8H)-carboxylate
CAS 681249-59-2C11H15F3N4O2
![8-Methyl-2-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine chemical structure, C7H9F3N4, CAS 781614-02-6](/s/QLEVXYXJLSXVMY-UHFFFAOYSA-N.svg)
8-Methyl-2-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine
CAS 781614-02-6C7H9F3N4
![2-Hydroxymethyl-5,6-dihydro-8H-[1,2,4]triazolo[1,5-a]pyrazine-7-carboxylic acid tert-butyl ester chemical structure, C11H18N4O3, CAS 265643-95-6](/s/XJUYVCKMKUYQFQ-UHFFFAOYSA-N.svg)
2-Hydroxymethyl-5,6-dihydro-8H-[1,2,4]triazolo[1,5-a]pyrazine-7-carboxylic acid tert-butyl ester
CAS 265643-95-6C11H18N4O3
![5,6,7,8-Tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine-2-carboxylic acid chemical structure, C6H8N4O2, CAS 1029721-05-8](/s/ALDLSBPANOIMJZ-UHFFFAOYSA-N.svg)
5,6,7,8-Tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine-2-carboxylic acid
CAS 1029721-05-8C6H8N4O2
![7-Isopropyl-6,8-dihydro-5H-[1,2,4]triazolo[1,5-a]pyrazine chemical structure, C8H14N4, CAS 1862861-25-3](/s/OAJANBJUKWIMAM-UHFFFAOYSA-N.svg)
7-Isopropyl-6,8-dihydro-5H-[1,2,4]triazolo[1,5-a]pyrazine
CAS 1862861-25-3C8H14N4
![2-(tert-Butyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine chemical structure, C9H16N4, CAS 914654-91-4](/s/KUASBBVZKOQOBX-UHFFFAOYSA-N.svg)
2-(tert-Butyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine
CAS 914654-91-4C9H16N4
![Ethyl 5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine-2-carboxylate chemical structure, C8H12N4O2, CAS 1422344-37-3](/s/BVFLUANJWRSBEV-UHFFFAOYSA-N.svg)
Ethyl 5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine-2-carboxylate
CAS 1422344-37-3C8H12N4O2
![7-(tert-Butyl) 2-ethyl 5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazine-2,7(8H)-dicarboxylate chemical structure, C13H20N4O4, CAS 265643-94-5](/s/RLAMWJAETDETPY-UHFFFAOYSA-N.svg)
7-(tert-Butyl) 2-ethyl 5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazine-2,7(8H)-dicarboxylate
CAS 265643-94-5C13H20N4O4
![5,6,7,8-Tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine hydrochloride chemical structure, C5H9ClN4, CAS 874360-12-0](/s/WGZYSQZUUCMDSA-UHFFFAOYSA-N.svg)
5,6,7,8-Tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine hydrochloride
CAS 874360-12-0C5H9ClN4
![2-Bromo-5H,6H,7H,8H-[1,2,4]triazolo[1,5-a]pyrazine chemical structure, C5H7BrN4, CAS 1260663-45-3](/s/BNVAZAPQPSGAOX-UHFFFAOYSA-N.svg)
2-Bromo-5H,6H,7H,8H-[1,2,4]triazolo[1,5-a]pyrazine
CAS 1260663-45-3C5H7BrN4
![2-Isopropyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine chemical structure, C8H14N4, CAS 1213257-22-7](/s/DZSFSNOFNIVNRW-UHFFFAOYSA-N.svg)
2-Isopropyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine
CAS 1213257-22-7C8H14N4
![2-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine hydrochloride chemical structure, C6H8ClF3N4, CAS 1013905-12-8](/s/IMHKQIUGWAESGE-UHFFFAOYSA-N.svg)
2-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine hydrochloride
CAS 1013905-12-8C6H8ClF3N4
![2-Methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine hydrochloride chemical structure, C6H11ClN4, CAS 1263378-55-7](/s/PDGHREKDLLUVKX-UHFFFAOYSA-N.svg)
2-Methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine hydrochloride
CAS 1263378-55-7C6H11ClN4
![tert-Butyl 2-formyl-5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazine-7(8H)-carboxylate chemical structure, C11H16N4O3, CAS 1893991-79-1](/s/JUCTYKQQWVECCZ-UHFFFAOYSA-N.svg)
tert-Butyl 2-formyl-5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazine-7(8H)-carboxylate
CAS 1893991-79-1C11H16N4O3
![2-(7-Methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)acetic acid chemical structure, C8H12N4O2, CAS 1368155-43-4](/s/ORAQCRVBBSVTPU-UHFFFAOYSA-N.svg)
2-(7-Methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)acetic acid
CAS 1368155-43-4C8H12N4O2
![2-Ethyl-5H,6H,7H,8H-[1,2,4]triazolo[1,5-a]pyrazine chemical structure, C7H12N4, CAS 1540029-46-6](/s/VPTHXEYLLVXSGC-UHFFFAOYSA-N.svg)
2-Ethyl-5H,6H,7H,8H-[1,2,4]triazolo[1,5-a]pyrazine
CAS 1540029-46-6C7H12N4
![(7-Methyl-6,8-dihydro-5H-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)methanamine chemical structure, C7H13N5, CAS 1535975-01-9](/s/BLTYOFNFVBSZED-UHFFFAOYSA-N.svg)
(7-Methyl-6,8-dihydro-5H-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)methanamine
CAS 1535975-01-9C7H13N5
- 1-(7-Methyl-6,8-dihydro-5H-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)ethanone1518246-25-7C8H12N4O
- 5H,6H,7H,8H-[1,2,4]Triazolo[1,5-a]pyrazin-2-amine1554483-44-1C5H9N5
- 7-Methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazin-2-amine1434053-29-8C6H11N5
- 2-Chloro-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-A]pyrazine1552705-51-7C5H7ClN4
- 5H,6H,7H,8H-[1,2,4]Triazolo[1,5-a]pyrazine-6-carboxylic acid1779409-49-2C6H8N4O2
- 2-Methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine-6-carboxylic acid1779623-09-4C7H10N4O2
- 2-Isopropyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine-6-carboxylic acid1779410-99-9C9H14N4O2
- 2-tert-Butyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine-6-carboxylic acid2103682-01-3C10H16N4O2
- tert-Butyl 7-Methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazin-2-yl-carbamate1434053-28-7C11H19N5O2
- tert-Butyl (5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)carbamate1434053-27-6C10H17N5O2
- tert-Butyl 2-bromo-5H,6H,7H,8H-(1,2,4)triazolo(1,5-a)pyrazine-7-carboxylate1575613-02-3C10H15BrN4O2
- 7-Methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazin-2-amine hydrochloride1956380-46-3C6H12ClN5
- 2,8-Dimethyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine1956379-10-4C7H12N4
- 1-{2-Methyl-5H,6H,7H,8H-[1,2,4]triazolo[1,5-a]pyrazin-7-yl}prop-2-en-1-one2094750-07-7C9H12N4O
- 1-{2-Bromo-5H,6H,7H,8H-[1,2,4]triazolo[1,5-a]pyrazin-7-yl}butan-1-one2059933-12-7C9H13BrN4O
- 1-{2-Bromo-5H,6H,7H,8H-[1,2,4]triazolo[1,5-a]pyrazin-7-yl}-2-methylpropan-1-one2060027-89-4C9H13BrN4O
- 1-{2-Bromo-5H,6H,7H,8H-[1,2,4]triazolo[1,5-a]pyrazin-7-yl}-2,2-dimethylpropan-1-one2060062-56-6C10H15BrN4O
- 1-{2-Bromo-5H,6H,7H,8H-[1,2,4]triazolo[1,5-a]pyrazin-7-yl}-4-chlorobutan-1-one2060040-70-0C9H12BrClN4O
- 1-{2-Bromo-5H,6H,7H,8H-[1,2,4]triazolo[1,5-a]pyrazin-7-yl}-2-methoxyethan-1-one2060026-19-7C8H11BrN4O2
- 1-{2-Bromo-5H,6H,7H,8H-[1,2,4]triazolo[1,5-a]pyrazin-7-yl}propan-1-one2059966-27-5C8H11BrN4O
- 2-(2-Methylpropyl)-5H,6H,7H,8H-[1,2,4]triazolo[1,5-a]pyrazine2060050-21-5C9H16N4
- 1-{2-Bromo-5H,6H,7H,8H-[1,2,4]triazolo[1,5-a]pyrazin-7-yl}-3-chloro-2,2-dimethylpropan-1-one2059945-47-8C10H14BrClN4O
- 1-{2-Bromo-5H,6H,7H,8H-[1,2,4]triazolo[1,5-a]pyrazin-7-yl}ethan-1-one2060058-84-4C7H9BrN4O
- 1-{2-Bromo-5H,6H,7H,8H-[1,2,4]triazolo[1,5-a]pyrazin-7-yl}-3-chloropropan-1-one2060006-75-7C8H10BrClN4O
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