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Murcko scaffold

2H-Isoindole-2-acetamide, 1,3-dihydro-1,3-dioxo-N-(2-phenylethyl)- scaffold

13 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
23
Chemicals
13
With full pages
3
Scaffold SMILES

O=C(CN1C(=O)c2ccccc2C1=O)NCCc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2H-Isoindole-2-acetamide, 1,3-dihydro-1,3-dioxo-N-(2-phenylethyl)- page
Murcko scaffold O=C(CN1C(=O)c2ccccc2C1=O)NCCc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 13 of 13 chemicals

N-[(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)acetyl]phenylalanine chemical structure, C19H16N2O5, CAS 60676-54-2
N-[(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)acetyl]phenylalanine
CAS 60676-54-2C19H16N2O5
2H-Isoindole-2-acetamide, 1,3-dihydro-1,3-dioxo-N-(2-phenylethyl)- chemical structure, C18H16N2O3, CAS 88422-74-6
2H-Isoindole-2-acetamide, 1,3-dihydro-1,3-dioxo-N-(2-phenylethyl)-
CAS 88422-74-6C18H16N2O3
2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-[2-(4-methoxyphenyl)ethyl]acetamide chemical structure, C19H18N2O4, CAS 305377-27-9
2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-[2-(4-methoxyphenyl)ethyl]acetamide
CAS 305377-27-9C19H18N2O4
N-[2-(3,4-Dimethoxyphenyl)ethyl]-2-(1,3-dioxobenzo[c]azolin-2-yl)acetamide chemical structure, C20H20N2O5, CAS 31633-29-1
N-[2-(3,4-Dimethoxyphenyl)ethyl]-2-(1,3-dioxobenzo[c]azolin-2-yl)acetamide
CAS 31633-29-1C20H20N2O5
2-(1,3-Dioxoisoindolin-2-yl)-N-(4-sulfamoylphenethyl)acetamide chemical structure, C18H17N3O5S, CAS 349542-40-1
2-(1,3-Dioxoisoindolin-2-yl)-N-(4-sulfamoylphenethyl)acetamide
CAS 349542-40-1C18H17N3O5S
N-[2-(3,4-Dimethoxyphenyl)ethyl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-methylbutanamide chemical structure, C23H26N2O5, CAS 303990-65-0
N-[2-(3,4-Dimethoxyphenyl)ethyl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-methylbutanamide
CAS 303990-65-0C23H26N2O5
2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-N-phenethyl-propionamide chemical structure, C19H18N2O3, CAS 332150-52-4
2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-N-phenethyl-propionamide
CAS 332150-52-4C19H18N2O3
N-[2-(Dimethylamino)-2-phenylethyl]-1,3-dihydro-I+/--methyl-1,3-dioxo-2H-isoindole-2-acetamide chemical structure, C21H23N3O3, CAS 744204-13-5
N-[2-(Dimethylamino)-2-phenylethyl]-1,3-dihydro-I+/--methyl-1,3-dioxo-2H-isoindole-2-acetamide
CAS 744204-13-5C21H23N3O3
Alanine, 3-phenyl-N-(phthalimidoacetyl)-, L- chemical structure, C19H16N2O5, CAS 1170-07-6
Alanine, 3-phenyl-N-(phthalimidoacetyl)-, L-
CAS 1170-07-6C19H16N2O5
2-(1,3-Dioxoisoindolin-2-yl)-N-(1-hydroxy-3-phenylpropan-2-yl)acetamide chemical structure, C19H18N2O4, CAS 1790174-02-5
2-(1,3-Dioxoisoindolin-2-yl)-N-(1-hydroxy-3-phenylpropan-2-yl)acetamide
CAS 1790174-02-5C19H18N2O4
2-(1,3-Dioxoisoindolin-2-yl)-N-(3-methoxyphenethyl)acetamide chemical structure, C19H18N2O4, CAS 1552267-05-6
2-(1,3-Dioxoisoindolin-2-yl)-N-(3-methoxyphenethyl)acetamide
CAS 1552267-05-6C19H18N2O4
Ethyl 2-(3,5-dimethoxyphenyl)-3-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetamido]propanoate chemical structure, C23H24N2O7, CAS 264188-62-7
Ethyl 2-(3,5-dimethoxyphenyl)-3-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetamido]propanoate
CAS 264188-62-7C23H24N2O7
2H-Isoindole-2-propanoic acid, 1,3-dihydro-I(2)-[[[2-methoxy-2-oxo-1-(phenylmethyl)ethyl]amino]carbonyl]-1,3-dioxo-, [S-(R*,R*)]- chemical structure, C22H20N2O7, CAS 98353-09-4
2H-Isoindole-2-propanoic acid, 1,3-dihydro-I(2)-[[[2-methoxy-2-oxo-1-(phenylmethyl)ethyl]amino]carbonyl]-1,3-dioxo-, [S-(R*,R*)]-
CAS 98353-09-4C22H20N2O7