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Murcko scaffold

Ring system with 3 rings and 24 atoms

28 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
24
Chemicals
28
With full pages
7
Scaffold SMILES

O=C(CN1C(=O)c2ccccc2C1=O)OCC(=O)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CN1C(=O)c2ccccc2C1=O)OCC(=O)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 28 of 28 chemicals

2-(4-Chlorophenyl)-2-oxoethyl (5-bromo-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetate chemical structure, C18H11BrClNO5, CAS 328549-56-0
2-(4-Chlorophenyl)-2-oxoethyl (5-bromo-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetate
CAS 328549-56-0C18H11BrClNO5
[2-(4-Methoxyphenyl)-2-oxoethyl] 2-(4-nitro-1,3-dioxoisoindol-2-yl)acetate chemical structure, C19H14N2O8, CAS 351895-68-6
[2-(4-Methoxyphenyl)-2-oxoethyl] 2-(4-nitro-1,3-dioxoisoindol-2-yl)acetate
CAS 351895-68-6C19H14N2O8
[2-Oxo-2-(2,3,5,6-tetramethylphenyl)ethyl] 2-(1,3-dioxoisoindol-2-yl)acetate chemical structure, C22H21NO5, CAS 313392-12-0
[2-Oxo-2-(2,3,5,6-tetramethylphenyl)ethyl] 2-(1,3-dioxoisoindol-2-yl)acetate
CAS 313392-12-0C22H21NO5
2-Oxo-2-(p-tolyl)ethyl 2-(1,3-dioxoisoindolin-2-yl)acetate chemical structure, C19H15NO5, CAS 348125-11-1
2-Oxo-2-(p-tolyl)ethyl 2-(1,3-dioxoisoindolin-2-yl)acetate
CAS 348125-11-1C19H15NO5
2-(4-Fluorophenyl)-2-oxoethyl 2-(1,3-dioxoisoindolin-2-yl)acetate chemical structure, C18H12FNO5, CAS 868153-30-4
2-(4-Fluorophenyl)-2-oxoethyl 2-(1,3-dioxoisoindolin-2-yl)acetate
CAS 868153-30-4C18H12FNO5
Phenacyl 2-(1,3-dioxoisoindol-2-yl)propanoate chemical structure, C19H15NO5, CAS 312497-38-4
Phenacyl 2-(1,3-dioxoisoindol-2-yl)propanoate
CAS 312497-38-4C19H15NO5
Phenacyl 3-methyl-2-(4-nitro-1,3-dioxoisoindol-2-yl)butanoate chemical structure, C21H18N2O7, CAS 351895-73-3
Phenacyl 3-methyl-2-(4-nitro-1,3-dioxoisoindol-2-yl)butanoate
CAS 351895-73-3C21H18N2O7
Phenacyl 2-(1,3-dioxoisoindol-2-yl)hexanoate chemical structure, C22H21NO5, CAS 335390-85-7
Phenacyl 2-(1,3-dioxoisoindol-2-yl)hexanoate
CAS 335390-85-7C22H21NO5
2-(4-Chlorophenyl)-2-oxoethyl 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-4-methylpentanoate chemical structure, C22H20ClNO5, CAS 356087-10-0
2-(4-Chlorophenyl)-2-oxoethyl 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-4-methylpentanoate
CAS 356087-10-0C22H20ClNO5
2-(4-Methylphenyl)-2-oxoethyl 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-4-methylpentanoate chemical structure, C23H23NO5, CAS 356087-13-3
2-(4-Methylphenyl)-2-oxoethyl 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-4-methylpentanoate
CAS 356087-13-3C23H23NO5
2-(3,4-Dimethylphenyl)-2-oxoethyl 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)hexanoate chemical structure, C24H25NO5, CAS 428845-12-9
2-(3,4-Dimethylphenyl)-2-oxoethyl 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)hexanoate
CAS 428845-12-9C24H25NO5
2-(4-Methoxyphenyl)-2-oxoethyl 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-4-methylpentanoate chemical structure, C23H23NO6, CAS 356087-16-6
2-(4-Methoxyphenyl)-2-oxoethyl 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-4-methylpentanoate
CAS 356087-16-6C23H23NO6
2-(4-Fluorophenyl)-2-oxoethyl 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanoate chemical structure, C19H14FNO5, CAS 432496-33-8
2-(4-Fluorophenyl)-2-oxoethyl 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanoate
CAS 432496-33-8C19H14FNO5
2-Oxo-2-phenylethyl 2-(4,5,6,7-tetrachloro-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanoate chemical structure, C19H11Cl4NO5, CAS 356092-04-1
2-Oxo-2-phenylethyl 2-(4,5,6,7-tetrachloro-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanoate
CAS 356092-04-1C19H11Cl4NO5
1-Oxo-1-phenylpropan-2-yl 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanoate chemical structure, C20H17NO5, CAS 432501-33-2
1-Oxo-1-phenylpropan-2-yl 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanoate
CAS 432501-33-2C20H17NO5
2-(4-Fluorophenyl)-2-oxoethyl 2-(4,5,6,7-tetrachloro-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanoate chemical structure, C19H10Cl4FNO5, CAS 432508-91-3
2-(4-Fluorophenyl)-2-oxoethyl 2-(4,5,6,7-tetrachloro-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanoate
CAS 432508-91-3C19H10Cl4FNO5
2-(3-Methoxyphenyl)-2-oxoethyl 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanoate chemical structure, C20H17NO6, CAS 432538-39-1
2-(3-Methoxyphenyl)-2-oxoethyl 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanoate
CAS 432538-39-1C20H17NO6
2-(2,4-Dichlorophenyl)-2-oxoethyl 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanoate chemical structure, C19H13Cl2NO5, CAS 433234-48-1
2-(2,4-Dichlorophenyl)-2-oxoethyl 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanoate
CAS 433234-48-1C19H13Cl2NO5
2-(4-Methylphenyl)-2-oxoethyl 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanoate chemical structure, C20H17NO5, CAS 433238-49-4
2-(4-Methylphenyl)-2-oxoethyl 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanoate
CAS 433238-49-4C20H17NO5
2-(3,4-Dimethylphenyl)-2-oxoethyl 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-4-(methylsulfanyl)butanoate chemical structure, C23H23NO5S, CAS 333443-63-3
2-(3,4-Dimethylphenyl)-2-oxoethyl 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-4-(methylsulfanyl)butanoate
CAS 333443-63-3C23H23NO5S
Phenacyl 2-(5,6-dichloro-1,3-dioxoisoindol-2-yl)-4-methylsulfanylbutanoate chemical structure, C21H17Cl2NO5S, CAS 355817-63-9
Phenacyl 2-(5,6-dichloro-1,3-dioxoisoindol-2-yl)-4-methylsulfanylbutanoate
CAS 355817-63-9C21H17Cl2NO5S
2-(4-Chlorophenyl)-2-oxoethyl 3-methyl-2-(4,5,6,7-tetrachloro-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butanoate chemical structure, C21H14Cl5NO5, CAS 352219-33-1
2-(4-Chlorophenyl)-2-oxoethyl 3-methyl-2-(4,5,6,7-tetrachloro-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butanoate
CAS 352219-33-1C21H14Cl5NO5
2-(2-Chlorophenyl)-2-oxoethyl 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-4-(methylsulfonyl)butanoate chemical structure, C21H18ClNO7S, CAS 664975-82-0
2-(2-Chlorophenyl)-2-oxoethyl 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-4-(methylsulfonyl)butanoate
CAS 664975-82-0C21H18ClNO7S
1-(4-Methoxyphenyl)-1-oxopropan-2-yl 2-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)acetate chemical structure, C20H17NO6, CAS 853903-30-7
1-(4-Methoxyphenyl)-1-oxopropan-2-yl 2-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)acetate
CAS 853903-30-7C20H17NO6