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Murcko scaffold

2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3,N-diphenyl-propionamide scaffold

30 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
28
Chemicals
30
With full pages
6
Scaffold SMILES

O=C(Nc1ccccc1)C(Cc1ccccc1)N1C(=O)c2ccccc2C1=O

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3,N-diphenyl-propionamide page
Murcko scaffold O=C(Nc1ccccc1)C(Cc1ccccc1)N1C(=O)c2ccccc2C1=O

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 30 of 30 chemicals

N-(4-Bromophenyl)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropanamide chemical structure, C23H17BrN2O3, CAS 303794-58-3
N-(4-Bromophenyl)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropanamide
CAS 303794-58-3C23H17BrN2O3
2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenyl-N-[2-(trifluoromethyl)phenyl]propanamide chemical structure, C24H17F3N2O3, CAS 303795-14-4
2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenyl-N-[2-(trifluoromethyl)phenyl]propanamide
CAS 303795-14-4C24H17F3N2O3
N-(3-Acetylphenyl)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropanamide chemical structure, C25H20N2O4, CAS 5314-77-2
N-(3-Acetylphenyl)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropanamide
CAS 5314-77-2C25H20N2O4
2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3,N-diphenyl-propionamide chemical structure, C23H18N2O3, CAS 99481-69-3
2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3,N-diphenyl-propionamide
CAS 99481-69-3C23H18N2O3
2-(1,3-Dioxoisoindol-2-yl)-N-(4-methyl-3-nitrophenyl)-3-phenylpropanamide chemical structure, C24H19N3O5, CAS 294655-45-1
2-(1,3-Dioxoisoindol-2-yl)-N-(4-methyl-3-nitrophenyl)-3-phenylpropanamide
CAS 294655-45-1C24H19N3O5
N-(4-Acetylphenyl)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropanamide chemical structure, C25H20N2O4, CAS 294655-59-7
N-(4-Acetylphenyl)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropanamide
CAS 294655-59-7C25H20N2O4
2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-(4-methylphenyl)-3-phenylpropanamide chemical structure, C24H20N2O3, CAS 140244-45-7
2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-(4-methylphenyl)-3-phenylpropanamide
CAS 140244-45-7C24H20N2O3
2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-(4-methoxyphenyl)-3-phenylpropanamide chemical structure, C24H20N2O4, CAS 140244-47-9
2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-(4-methoxyphenyl)-3-phenylpropanamide
CAS 140244-47-9C24H20N2O4
N-(3-Bromophenyl)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropanamide chemical structure, C23H17BrN2O3, CAS 347914-23-2
N-(3-Bromophenyl)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropanamide
CAS 347914-23-2C23H17BrN2O3
N-(5-Chloro-2-methylphenyl)-2-(1,3-dioxoisoindol-2-yl)-3-phenylpropanamide chemical structure, C24H19ClN2O3, CAS 5765-73-1
N-(5-Chloro-2-methylphenyl)-2-(1,3-dioxoisoindol-2-yl)-3-phenylpropanamide
CAS 5765-73-1C24H19ClN2O3
N-(3,4-Dichlorophenyl)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropanamide chemical structure, C23H16Cl2N2O3, CAS 4147-77-7
N-(3,4-Dichlorophenyl)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropanamide
CAS 4147-77-7C23H16Cl2N2O3
Ethyl 2-{[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropanoyl]amino}benzoate chemical structure, C26H22N2O5, CAS 294647-04-4
Ethyl 2-{[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropanoyl]amino}benzoate
CAS 294647-04-4C26H22N2O5
2-(1,3-Dioxoisoindol-2-yl)-N-(4-ethoxyphenyl)-3-(4-nitrophenyl)propanamide chemical structure, C25H21N3O6, CAS 5214-20-0
2-(1,3-Dioxoisoindol-2-yl)-N-(4-ethoxyphenyl)-3-(4-nitrophenyl)propanamide
CAS 5214-20-0C25H21N3O6
2-{[2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropanoyl]amino}benzoic acid chemical structure, C24H18N2O5, CAS 364739-06-0
2-{[2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropanoyl]amino}benzoic acid
CAS 364739-06-0C24H18N2O5
2-(1,3-Dioxoisoindol-2-yl)-N-(4-fluorophenyl)-3-phenylpropanamide chemical structure, C23H17FN2O3, CAS 355422-19-4
2-(1,3-Dioxoisoindol-2-yl)-N-(4-fluorophenyl)-3-phenylpropanamide
CAS 355422-19-4C23H17FN2O3
N-(4-Chlorophenyl)-2-(5,6-dichloro-1,3-dioxoisoindol-2-yl)-3-phenylpropanamide chemical structure, C23H15Cl3N2O3, CAS 355422-32-1
N-(4-Chlorophenyl)-2-(5,6-dichloro-1,3-dioxoisoindol-2-yl)-3-phenylpropanamide
CAS 355422-32-1C23H15Cl3N2O3
N-(2-Chlorophenyl)-2-(5,6-dichloro-1,3-dioxoisoindol-2-yl)-3-phenylpropanamide chemical structure, C23H15Cl3N2O3, CAS 355422-38-7
N-(2-Chlorophenyl)-2-(5,6-dichloro-1,3-dioxoisoindol-2-yl)-3-phenylpropanamide
CAS 355422-38-7C23H15Cl3N2O3
N-(2,6-Dimethylphenyl)-2-(4-nitro-1,3-dioxo-isoindol-2-yl)-3-phenyl-propanamide chemical structure, C25H21N3O5, CAS 6529-27-7
N-(2,6-Dimethylphenyl)-2-(4-nitro-1,3-dioxo-isoindol-2-yl)-3-phenyl-propanamide
CAS 6529-27-7C25H21N3O5
2-(5,6-Dichloro-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-(2,5-dimethylphenyl)-3-phenylpropanamide chemical structure, C25H20Cl2N2O3, CAS 6530-43-4
2-(5,6-Dichloro-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-(2,5-dimethylphenyl)-3-phenylpropanamide
CAS 6530-43-4C25H20Cl2N2O3
N-(2,6-Dimethylphenyl)-2-(1,3-dioxoisoindol-2-yl)-3-phenylpropanamide chemical structure, C25H22N2O3, CAS 355422-22-9
N-(2,6-Dimethylphenyl)-2-(1,3-dioxoisoindol-2-yl)-3-phenylpropanamide
CAS 355422-22-9C25H22N2O3
2-(5,6-Dichloro-1,3-dioxoisoindol-2-yl)-N-(3-methylphenyl)-3-phenylpropanamide chemical structure, C24H18Cl2N2O3, CAS 355422-25-2
2-(5,6-Dichloro-1,3-dioxoisoindol-2-yl)-N-(3-methylphenyl)-3-phenylpropanamide
CAS 355422-25-2C24H18Cl2N2O3
N-(2,5-Dimethylphenyl)-2-(1,3-dioxoisoindol-2-yl)-3-phenylpropanamide chemical structure, C25H22N2O3, CAS 355422-20-7
N-(2,5-Dimethylphenyl)-2-(1,3-dioxoisoindol-2-yl)-3-phenylpropanamide
CAS 355422-20-7C25H22N2O3
N-(3-Chlorophenyl)-2-(5,6-dichloro-1,3-dioxoisoindol-2-yl)-3-phenylpropanamide chemical structure, C23H15Cl3N2O3, CAS 355422-37-6
N-(3-Chlorophenyl)-2-(5,6-dichloro-1,3-dioxoisoindol-2-yl)-3-phenylpropanamide
CAS 355422-37-6C23H15Cl3N2O3
N-(2-Bromophenyl)-2-(1,3-dioxoisoindol-2-yl)-3-phenylpropanamide chemical structure, C23H17BrN2O3, CAS 385424-40-8
N-(2-Bromophenyl)-2-(1,3-dioxoisoindol-2-yl)-3-phenylpropanamide
CAS 385424-40-8C23H17BrN2O3