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Murcko scaffold

1,4-Dioxa-8-azaspiro[4.5]dec-8-yl(phenyl)methanone scaffold

9 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
9
With full pages
2
Scaffold SMILES

O=C(c1ccccc1)N1CCC2(CC1)OCCO2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1,4-Dioxa-8-azaspiro[4.5]dec-8-yl(phenyl)methanone page
Murcko scaffold O=C(c1ccccc1)N1CCC2(CC1)OCCO2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 9 of 9 chemicals

Ethyl 2-(8-benzoyl-1,4-dioxa-8-azaspiro[4.5]decan-6-yl)acetate chemical structure, C18H23NO5, CAS 7511-23-1
Ethyl 2-(8-benzoyl-1,4-dioxa-8-azaspiro[4.5]decan-6-yl)acetate
CAS 7511-23-1C18H23NO5
2-(8-Benzoyl-1,4-dioxa-8-azaspiro[4.5]decan-6-yl)-N,N-dimethylacetamide chemical structure, C18H24N2O4, CAS 7511-24-2
2-(8-Benzoyl-1,4-dioxa-8-azaspiro[4.5]decan-6-yl)-N,N-dimethylacetamide
CAS 7511-24-2C18H24N2O4
8-(4-Fluorobenzoyl)-1,4-dioxa-8-azaspiro[4.5]decane chemical structure, C14H16FNO3, CAS 190012-29-4
8-(4-Fluorobenzoyl)-1,4-dioxa-8-azaspiro[4.5]decane
CAS 190012-29-4C14H16FNO3
1,4-Dioxa-8-azaspiro[4.5]dec-8-yl(phenyl)methanone chemical structure, C14H17NO3, CAS 84157-05-1
1,4-Dioxa-8-azaspiro[4.5]dec-8-yl(phenyl)methanone
CAS 84157-05-1C14H17NO3
(6-Bromo-1,4-dioxa-8-azaspiro[4.5]dec-8-yl)phenylmethanone chemical structure, C14H16BrNO3, CAS 84157-06-2
(6-Bromo-1,4-dioxa-8-azaspiro[4.5]dec-8-yl)phenylmethanone
CAS 84157-06-2C14H16BrNO3
(3,5-Dimethylphenyl)(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)methanone chemical structure, C16H21NO3, CAS 190012-44-3
(3,5-Dimethylphenyl)(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)methanone
CAS 190012-44-3C16H21NO3
1-(4-Cyanobenzoyl)-4-piperidone ethylene ketal chemical structure, C15H16N2O3, CAS 190012-09-0
1-(4-Cyanobenzoyl)-4-piperidone ethylene ketal
CAS 190012-09-0C15H16N2O3
(3-tert-Butyl-4-hydroxyphenyl)(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methanone chemical structure, C18H25NO4, CAS 912999-00-9
(3-tert-Butyl-4-hydroxyphenyl)(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methanone
CAS 912999-00-9C18H25NO4
(3-Chloro-4-fluorophenyl)-1,4-dioxa-8-azaspiro[4.5]dec-8-ylmethanone chemical structure, C14H15ClFNO3, CAS 1332598-06-7
(3-Chloro-4-fluorophenyl)-1,4-dioxa-8-azaspiro[4.5]dec-8-ylmethanone
CAS 1332598-06-7C14H15ClFNO3