Murcko scaffold
8-Benzyl-1,4-dioxa-8-azaspiro[4.5]decane scaffold
52 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 17
- Chemicals
- 52
- With full pages
- 1
Scaffold SMILES
c1ccc(CN2CCC3(CC2)OCCO3)cc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 52 chemicals
![8-Benzyl-1,4-dioxa-8-azaspiro[4.5]decane chemical structure, C14H19NO2, CAS 37943-54-7](/s/AOAMQMAEEUONRT-UHFFFAOYSA-N.svg)
8-Benzyl-1,4-dioxa-8-azaspiro[4.5]decane
CAS 37943-54-7C14H19NO2
(8-Benzyl-1,4-dioxa-8-aza-spiro(4.5)dec-6-yl)-methanol
CAS 64996-15-2C15H21NO3
![8-[(2-Chloro-4-fluorophenyl)methyl]-1,4-dioxa-8-azaspiro[4.5]decane chemical structure, C14H17ClFNO2, CAS 904750-62-5](/s/CISFMVBSPQXMNB-UHFFFAOYSA-N.svg)
8-[(2-Chloro-4-fluorophenyl)methyl]-1,4-dioxa-8-azaspiro[4.5]decane
CAS 904750-62-5C14H17ClFNO2
![8-[(3-Fluorophenyl)methyl]-1,4-dioxa-8-azaspiro[4.5]decane chemical structure, C14H18FNO2, CAS 155868-52-3](/s/MCWPOEPNYMCVLP-UHFFFAOYSA-N.svg)
8-[(3-Fluorophenyl)methyl]-1,4-dioxa-8-azaspiro[4.5]decane
CAS 155868-52-3C14H18FNO2
![8-[(4-Chlorophenyl)methyl]-1,4-dioxa-8-azaspiro[4.5]decane chemical structure, C14H18ClNO2, CAS 802024-69-7](/s/OYENTFXVZINGGF-UHFFFAOYSA-N.svg)
8-[(4-Chlorophenyl)methyl]-1,4-dioxa-8-azaspiro[4.5]decane
CAS 802024-69-7C14H18ClNO2
![8-[(3-Methylphenyl)methyl]-1,4-dioxa-8-azaspiro[4.5]decane chemical structure, C15H21NO2, CAS 904750-60-3](/s/CUTPRIBAWBLYJU-UHFFFAOYSA-N.svg)
8-[(3-Methylphenyl)methyl]-1,4-dioxa-8-azaspiro[4.5]decane
CAS 904750-60-3C15H21NO2
![8-(4-Bromobenzyl)-1,4-dioxa-8-azaspiro[4.5]decane chemical structure, C14H18BrNO2, CAS 904750-36-3](/s/MJANUFLPRSVKPI-UHFFFAOYSA-N.svg)
8-(4-Bromobenzyl)-1,4-dioxa-8-azaspiro[4.5]decane
CAS 904750-36-3C14H18BrNO2
![8-[(2-Chloro-6-fluorophenyl)methyl]-1,4-dioxa-8-azaspiro[4.5]decane chemical structure, C14H17ClFNO2, CAS 904750-66-9](/s/WIINRGGHJNNSHC-UHFFFAOYSA-N.svg)
8-[(2-Chloro-6-fluorophenyl)methyl]-1,4-dioxa-8-azaspiro[4.5]decane
CAS 904750-66-9C14H17ClFNO2
![8-[(2,6-Dichlorophenyl)methyl]-1,4-dioxa-8-azaspiro[4.5]decane chemical structure, C14H17Cl2NO2, CAS 904750-00-1](/s/FIMCBURVRFFIGR-UHFFFAOYSA-N.svg)
8-[(2,6-Dichlorophenyl)methyl]-1,4-dioxa-8-azaspiro[4.5]decane
CAS 904750-00-1C14H17Cl2NO2
![8-[(3-Bromophenyl)methyl]-1,4-dioxa-8-azaspiro[4.5]decane chemical structure, C14H18BrNO2, CAS 904696-75-9](/s/VFWPNCFWUFQIQV-UHFFFAOYSA-N.svg)
8-[(3-Bromophenyl)methyl]-1,4-dioxa-8-azaspiro[4.5]decane
CAS 904696-75-9C14H18BrNO2
![8-(3-Methoxybenzyl)-1,4-dioxa-8-azaspiro[4.5]decane chemical structure, C15H21NO3, CAS 904750-10-3](/s/YPULJABOHAOAPP-UHFFFAOYSA-N.svg)
8-(3-Methoxybenzyl)-1,4-dioxa-8-azaspiro[4.5]decane
CAS 904750-10-3C15H21NO3
![8-{[4-(Trifluoromethyl)phenyl]methyl}-1,4-dioxa-8-azaspiro[4.5]decane chemical structure, C15H18F3NO2, CAS 905986-82-5](/s/UWVFABUXDGZYIP-UHFFFAOYSA-N.svg)
8-{[4-(Trifluoromethyl)phenyl]methyl}-1,4-dioxa-8-azaspiro[4.5]decane
CAS 905986-82-5C15H18F3NO2
![8-(Phenylmethyl)-1,4-dioxa-8-azaspiro[4.5]decane-6-carboxylic acid methyl ester chemical structure, C16H21NO4, CAS 64996-14-1](/s/YQBUDFCCCDYXEU-UHFFFAOYSA-N.svg)
8-(Phenylmethyl)-1,4-dioxa-8-azaspiro[4.5]decane-6-carboxylic acid methyl ester
CAS 64996-14-1C16H21NO4
![3-[8-(1,4-Dioxa-8-azaspiro[4.5]decyl)methyl]phenylmagnesium bromide 0.25 M in Tetrahydrofuran chemical structure, C14H18BrMgNO2, CAS 1173019-46-9](/s/VPALMDYRGFPRQH-UHFFFAOYSA-M.svg)
3-[8-(1,4-Dioxa-8-azaspiro[4.5]decyl)methyl]phenylmagnesium bromide 0.25 M in Tetrahydrofuran
CAS 1173019-46-9C14H18BrMgNO2
![8-[(3,4-Dichlorophenyl)methyl]-1,4-dioxa-8-azaspiro[4.5]decane chemical structure, C14H17Cl2NO2, CAS 904750-12-5](/s/MHLHTEHTCVNEBE-UHFFFAOYSA-N.svg)
8-[(3,4-Dichlorophenyl)methyl]-1,4-dioxa-8-azaspiro[4.5]decane
CAS 904750-12-5C14H17Cl2NO2
![2-[8-(1,4-Dioxa-8-azaspiro[4.5]decyl)methyl]phenylmagnesium bromide 0.25 M in Tetrahydrofuran chemical structure, C14H18BrMgNO2, CAS 1187170-36-0](/s/CHVBYFSVGITLFU-UHFFFAOYSA-M.svg)
2-[8-(1,4-Dioxa-8-azaspiro[4.5]decyl)methyl]phenylmagnesium bromide 0.25 M in Tetrahydrofuran
CAS 1187170-36-0C14H18BrMgNO2
![4-[8-(1,4-Dioxa-8-azaspiro[4.5]decyl)methyl]phenylmagnesium bromide 0.25 M in Tetrahydrofuran chemical structure, C14H18BrMgNO2, CAS 936490-38-9](/s/GFWGJLOLVHJYEM-UHFFFAOYSA-M.svg)
4-[8-(1,4-Dioxa-8-azaspiro[4.5]decyl)methyl]phenylmagnesium bromide 0.25 M in Tetrahydrofuran
CAS 936490-38-9C14H18BrMgNO2
![Ethyl 4-[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-ylmethyl)phenyl]-4-oxobutanoate chemical structure, C20H27NO5, CAS 898782-04-2](/s/GRKHPCGGQOZDEV-UHFFFAOYSA-N.svg)
Ethyl 4-[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-ylmethyl)phenyl]-4-oxobutanoate
CAS 898782-04-2C20H27NO5
![Ethyl 5-[4-[8-(1,4-dioxa-8-azaspiro[4.5]decyl)methyl]phenyl]-5-oxovalerate chemical structure, C21H29NO5, CAS 898782-07-5](/s/HVAJCABNCJCUGO-UHFFFAOYSA-N.svg)
Ethyl 5-[4-[8-(1,4-dioxa-8-azaspiro[4.5]decyl)methyl]phenyl]-5-oxovalerate
CAS 898782-07-5C21H29NO5
![Ethyl 7-(4-(1,4-dioxa-8-azaspiro[4.5]decan-8-ylmethyl)phenyl)-7-oxoheptanoate chemical structure, C23H33NO5, CAS 898782-13-3](/s/YBUQJZDFYVRJJY-UHFFFAOYSA-N.svg)
Ethyl 7-(4-(1,4-dioxa-8-azaspiro[4.5]decan-8-ylmethyl)phenyl)-7-oxoheptanoate
CAS 898782-13-3C23H33NO5
![Ethyl 8-(4-(1,4-dioxa-8-azaspiro[4.5]decan-8-ylmethyl)phenyl)-8-oxooctanoate chemical structure, C24H35NO5, CAS 898782-16-6](/s/LGSWDULJKNLIPS-UHFFFAOYSA-N.svg)
Ethyl 8-(4-(1,4-dioxa-8-azaspiro[4.5]decan-8-ylmethyl)phenyl)-8-oxooctanoate
CAS 898782-16-6C24H35NO5
![Ethyl 4-[3-[1,4-dioxa-8-azaspiro[4.5]decan-8-ylmethyl]phenyl]-4-oxobutyrate chemical structure, C20H27NO5, CAS 898762-58-8](/s/HWWWPSFSVAXJDM-UHFFFAOYSA-N.svg)
Ethyl 4-[3-[1,4-dioxa-8-azaspiro[4.5]decan-8-ylmethyl]phenyl]-4-oxobutyrate
CAS 898762-58-8C20H27NO5
![Ethyl 5-[3-[1,4-dioxa-8-azaspiro[4.5]decan-8-ylmethyl]phenyl]-5-oxovalerate chemical structure, C21H29NO5, CAS 898762-61-3](/s/XJRNKEIYSNRCBI-UHFFFAOYSA-N.svg)
Ethyl 5-[3-[1,4-dioxa-8-azaspiro[4.5]decan-8-ylmethyl]phenyl]-5-oxovalerate
CAS 898762-61-3C21H29NO5
![Ethyl 6-(3-(1,4-dioxa-8-azaspiro[4.5]decan-8-ylmethyl)phenyl)-6-oxohexanoate chemical structure, C22H31NO5, CAS 898762-64-6](/s/GYVCNVDGTHUSPG-UHFFFAOYSA-N.svg)
Ethyl 6-(3-(1,4-dioxa-8-azaspiro[4.5]decan-8-ylmethyl)phenyl)-6-oxohexanoate
CAS 898762-64-6C22H31NO5
- Ethyl 7-(3-(1,4-dioxa-8-azaspiro[4.5]decan-8-ylmethyl)phenyl)-7-oxoheptanoate898762-66-8C23H33NO5
- Ethyl 8-(3-(1,4-dioxa-8-azaspiro[4.5]decan-8-ylmethyl)phenyl)-8-oxooctanoate898762-68-0C24H35NO5
- Ethyl 4-[2-[8-(1,4-dioxa-8-azaspiro[4.5]decyl)methyl]phenyl]-4-oxobutyrate898781-23-2C20H27NO5
- Ethyl 5-[2-[8-(1,4-dioxa-8-azaspiro[4.5]decyl)methyl]phenyl]-5-oxovalerate898781-26-5C21H29NO5
- Ethyl 6-[2-(1,4-dioxa-8-azaspiro[4.5]decan-8-ylmethyl)phenyl]-6-oxohexanoate898781-29-8C22H31NO5
- Ethyl 7-(2-(1,4-dioxa-8-azaspiro[4.5]decan-8-ylmethyl)phenyl)-7-oxoheptanoate898781-32-3C23H33NO5
- Ethyl 8-(2-(1,4-dioxa-8-azaspiro[4.5]decan-8-ylmethyl)phenyl)-8-oxooctanoate898781-35-6C24H35NO5
- 4-({1,4-Dioxa-8-azaspiro[4.5]decan-8-yl}methyl)benzonitrile1057268-16-2C15H18N2O2
- 8-(4-Bromo-2-chlorobenzyl)-1,4-dioxa-8-azaspiro[4.5]decane1704074-50-9C14H17BrClNO2
- B-[3-(1,4-Dioxa-8-azaspiro[4.5]dec-8-ylmethyl)phenyl]boronic acid1398635-10-3C14H20BNO4
- 8-[(2,6-Dimethoxyphenyl)methyl]-1,4-dioxa-8-azaspiro[4.5]decane832082-40-3C16H23NO4
- 8-(3-Bromo-5-fluorobenzyl)-1,4-dioxa-8-azaspiro[4.5]decane1506296-07-6C14H17BrFNO2
- (4-(1,4-Dioxa-8-azaspiro[4.5]decan-8-ylmethyl)phenyl)boronic acid1704073-94-8C14H20BNO4
- (4-(1,4-Dioxa-8-azaspiro[4.5]decan-8-ylmethyl)-3-fluorophenyl)boronic acid1704074-38-3C14H19BFNO4
- (3-(1,4-Dioxa-8-azaspiro[4.5]decan-8-ylmethyl)-4-chlorophenyl)boronic acid1704074-39-4C14H19BClNO4
- (4-(1,4-Dioxa-8-azaspiro[4.5]decan-8-ylmethyl)-3-chlorophenyl)boronic acid1704074-53-2C14H19BClNO4
- (3-(1,4-Dioxa-8-azaspiro[4.5]decan-8-ylmethyl)-5-fluorophenyl)boronic acid1704074-61-2C14H19BFNO4
- (4-(1,4-Dioxa-8-azaspiro[4.5]decan-8-ylmethyl)-2-fluorophenyl)boronic acid1704121-92-5C14H19BFNO4
- 8-(4-Bromo-2-fluorobenzyl)-1,4-dioxa-8-azaspiro[4.5]decane1478111-17-9C14H17BrFNO2
- 8-(5-Bromo-2-chlorobenzyl)-1,4-dioxa-8-azaspiro[4.5]decane1704074-41-8C14H17BrClNO2
- 8-(4-Bromo-3-fluorobenzyl)-1,4-dioxa-8-azaspiro[4.5]decane1704121-90-3C14H17BrFNO2
- 8-[(3-Fluoro-4-methoxyphenyl)methyl]-1,4-dioxa-8-azaspiro[4.5]decane1482431-94-6C15H20FNO3
- 8-[(2,5-Dimethylphenyl)methyl]-1,4-dioxa-8-azaspiro[4.5]decane1495858-15-5C16H23NO2
- 8-[(2-Bromophenyl)methyl]-1,4-dioxa-8-azaspiro[4.5]decane1057283-40-5C14H18BrNO2
Related scaffolds
Same ring framework with different atoms or bond orders
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