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Murcko scaffold

Ring system with 3 rings and 20 atoms

32 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
32
With full pages
5
Scaffold SMILES

O=C(CSc1nnc2ccccn12)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CSc1nnc2ccccn12)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 32 of 32 chemicals

2-([1,2,4]Triazolo[4,3-a]pyridin-3-ylthio)-N-(3-acetylphenyl)acetamide chemical structure, C16H14N4O2S, CAS 301683-76-1
2-([1,2,4]Triazolo[4,3-a]pyridin-3-ylthio)-N-(3-acetylphenyl)acetamide
CAS 301683-76-1C16H14N4O2S
N-(2,5-Dimethylphenyl)-2-([1,2,4]triazolo[4,3-a]pyridin-3-ylsulfanyl)acetamide chemical structure, C16H16N4OS, CAS 307511-39-3
N-(2,5-Dimethylphenyl)-2-([1,2,4]triazolo[4,3-a]pyridin-3-ylsulfanyl)acetamide
CAS 307511-39-3C16H16N4OS
2-([1,2,4]Triazolo[4,3-a]pyridin-3-ylthio)-N-(4-fluorophenyl)acetamide chemical structure, C14H11FN4OS, CAS 304684-03-5
2-([1,2,4]Triazolo[4,3-a]pyridin-3-ylthio)-N-(4-fluorophenyl)acetamide
CAS 304684-03-5C14H11FN4OS
Methyl 4-{[([1,2,4]triazolo[4,3-a]pyridin-3-ylsulfanyl)acetyl]amino}benzoate chemical structure, C16H14N4O3S, CAS 315696-26-5
Methyl 4-{[([1,2,4]triazolo[4,3-a]pyridin-3-ylsulfanyl)acetyl]amino}benzoate
CAS 315696-26-5C16H14N4O3S
N-(2-Ethoxyphenyl)-2-([1,2,4]triazolo[4,3-a]pyridin-3-ylsulfanyl)acetamide chemical structure, C16H16N4O2S, CAS 379249-04-4
N-(2-Ethoxyphenyl)-2-([1,2,4]triazolo[4,3-a]pyridin-3-ylsulfanyl)acetamide
CAS 379249-04-4C16H16N4O2S
N-(2,6-Difluorophenyl)-2-([1,2,4]triazolo[4,3-a]pyridin-3-ylsulfanyl)acetamide chemical structure, C14H10F2N4OS, CAS 379238-71-8
N-(2,6-Difluorophenyl)-2-([1,2,4]triazolo[4,3-a]pyridin-3-ylsulfanyl)acetamide
CAS 379238-71-8C14H10F2N4OS
N-(4-tert-Butylphenyl)-2-{[1,2,4]triazolo[4,3-a]pyridin-3-ylsulfanyl}acetamide chemical structure, C18H20N4OS, CAS 379239-53-9
N-(4-tert-Butylphenyl)-2-{[1,2,4]triazolo[4,3-a]pyridin-3-ylsulfanyl}acetamide
CAS 379239-53-9C18H20N4OS
2-([1,2,4]Triazolo[4,3-a]pyridin-3-ylthio)-N-(3-methoxyphenyl)acetamide chemical structure, C15H14N4O2S, CAS 379239-57-3
2-([1,2,4]Triazolo[4,3-a]pyridin-3-ylthio)-N-(3-methoxyphenyl)acetamide
CAS 379239-57-3C15H14N4O2S
2-([1,2,4]Triazolo[4,3-a]pyridin-3-ylthio)-N-(4-methoxyphenyl)acetamide chemical structure, C15H14N4O2S, CAS 307341-00-0
2-([1,2,4]Triazolo[4,3-a]pyridin-3-ylthio)-N-(4-methoxyphenyl)acetamide
CAS 307341-00-0C15H14N4O2S
N-(2,4-Dimethylphenyl)-2-([1,2,4]triazolo[4,3-a]pyridin-3-ylsulfanyl)acetamide chemical structure, C16H16N4OS, CAS 304643-32-1
N-(2,4-Dimethylphenyl)-2-([1,2,4]triazolo[4,3-a]pyridin-3-ylsulfanyl)acetamide
CAS 304643-32-1C16H16N4OS
N-(4-Ethoxyphenyl)-2-([1,2,4]triazolo[4,3-a]pyridin-3-ylsulfanyl)acetamide chemical structure, C16H16N4O2S, CAS 304691-51-8
N-(4-Ethoxyphenyl)-2-([1,2,4]triazolo[4,3-a]pyridin-3-ylsulfanyl)acetamide
CAS 304691-51-8C16H16N4O2S
N-(2-Fluorophenyl)-2-([1,2,4]triazolo[4,3-a]pyridin-3-ylsulfanyl)acetamide chemical structure, C14H11FN4OS, CAS 307513-00-4
N-(2-Fluorophenyl)-2-([1,2,4]triazolo[4,3-a]pyridin-3-ylsulfanyl)acetamide
CAS 307513-00-4C14H11FN4OS
N-(3-Methylphenyl)-2-{[1,2,4]triazolo[4,3-a]pyridin-3-ylsulfanyl}acetamide chemical structure, C15H14N4OS, CAS 671199-03-4
N-(3-Methylphenyl)-2-{[1,2,4]triazolo[4,3-a]pyridin-3-ylsulfanyl}acetamide
CAS 671199-03-4C15H14N4OS
N-(4-Methylphenyl)-2-{[1,2,4]triazolo[4,3-A]pyridin-3-ylsulfanyl}acetamide chemical structure, C15H14N4OS, CAS 671198-93-9
N-(4-Methylphenyl)-2-{[1,2,4]triazolo[4,3-A]pyridin-3-ylsulfanyl}acetamide
CAS 671198-93-9C15H14N4OS
N-(3,5-Ditert-butylphenyl)-2-([1,2,4]triazolo[4,3-a]pyridin-3-ylsulfanyl)acetamide chemical structure, C22H28N4OS, CAS 671198-94-0
N-(3,5-Ditert-butylphenyl)-2-([1,2,4]triazolo[4,3-a]pyridin-3-ylsulfanyl)acetamide
CAS 671198-94-0C22H28N4OS
Dimethyl 5-{[([1,2,4]triazolo[4,3-a]pyridin-3-ylsulfanyl)acetyl]amino}benzene-1,3-dicarboxylate chemical structure, C18H16N4O5S, CAS 307513-52-6
Dimethyl 5-{[([1,2,4]triazolo[4,3-a]pyridin-3-ylsulfanyl)acetyl]amino}benzene-1,3-dicarboxylate
CAS 307513-52-6C18H16N4O5S
2-([1,2,4]Triazolo[4,3-a]pyridin-3-ylthio)-N-(4-bromophenyl)acetamide chemical structure, C14H11BrN4OS, CAS 304862-70-2
2-([1,2,4]Triazolo[4,3-a]pyridin-3-ylthio)-N-(4-bromophenyl)acetamide
CAS 304862-70-2C14H11BrN4OS
2-([1,2,4]Triazolo[4,3-a]pyridin-3-ylthio)-N-(2,4,6-trichlorophenyl)acetamide chemical structure, C14H9Cl3N4OS, CAS 496027-93-1
2-([1,2,4]Triazolo[4,3-a]pyridin-3-ylthio)-N-(2,4,6-trichlorophenyl)acetamide
CAS 496027-93-1C14H9Cl3N4OS
Dimethyl 2-(2-([1,2,4]triazolo[4,3-a]pyridin-3-ylthio)acetamido)terephthalate chemical structure, C18H16N4O5S, CAS 442865-32-9
Dimethyl 2-(2-([1,2,4]triazolo[4,3-a]pyridin-3-ylthio)acetamido)terephthalate
CAS 442865-32-9C18H16N4O5S
2-([1,2,4]Triazolo[4,3-a]pyridin-3-ylthio)-N-(2,6-dichlorophenyl)acetamide chemical structure, C14H10Cl2N4OS, CAS 780805-94-9
2-([1,2,4]Triazolo[4,3-a]pyridin-3-ylthio)-N-(2,6-dichlorophenyl)acetamide
CAS 780805-94-9C14H10Cl2N4OS
2-{[1,2,4]Triazolo[4,3-a]pyridin-3-ylsulfanyl}-N-[2-(trifluoromethyl)phenyl]acetamide chemical structure, C15H11F3N4OS, CAS 442865-44-3
2-{[1,2,4]Triazolo[4,3-a]pyridin-3-ylsulfanyl}-N-[2-(trifluoromethyl)phenyl]acetamide
CAS 442865-44-3C15H11F3N4OS
2-([1,2,4]Triazolo[4,3-a]pyridin-3-ylthio)-N-(4-sulfamoylphenyl)acetamide chemical structure, C14H13N5O3S2, CAS 446843-29-4
2-([1,2,4]Triazolo[4,3-a]pyridin-3-ylthio)-N-(4-sulfamoylphenyl)acetamide
CAS 446843-29-4C14H13N5O3S2
N-(2-Methoxyphenyl)-2-([1,2,4]triazolo[4,3-a]pyridin-3-ylsulfanyl)acetamide chemical structure, C15H14N4O2S, CAS 446851-51-0
N-(2-Methoxyphenyl)-2-([1,2,4]triazolo[4,3-a]pyridin-3-ylsulfanyl)acetamide
CAS 446851-51-0C15H14N4O2S
N-(2-Chlorophenyl)-2-([1,2,4]triazolo[4,3-a]pyridin-3-ylsulfanyl)acetamide chemical structure, C14H11ClN4OS, CAS 761421-54-9
N-(2-Chlorophenyl)-2-([1,2,4]triazolo[4,3-a]pyridin-3-ylsulfanyl)acetamide
CAS 761421-54-9C14H11ClN4OS