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Murcko scaffold

Ring system with 3 rings and 22 atoms

83 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
83
With full pages
22
Scaffold SMILES

O=C(CS(=O)(=O)c1c[nH]c2ccccc12)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CS(=O)(=O)c1c[nH]c2ccccc12)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 83 chemicals

2-((1H-Indol-3-yl)sulfonyl)-N-(4-fluorophenyl)acetamide chemical structure, C16H13FN2O3S, CAS 850932-30-8
2-((1H-Indol-3-yl)sulfonyl)-N-(4-fluorophenyl)acetamide
CAS 850932-30-8C16H13FN2O3S
2-(1-Methylindol-3-yl)sulfonyl-N-(4-methylphenyl)acetamide chemical structure, C18H18N2O3S, CAS 686743-46-4
2-(1-Methylindol-3-yl)sulfonyl-N-(4-methylphenyl)acetamide
CAS 686743-46-4C18H18N2O3S
N-[2-Chloro-5-(trifluoromethyl)phenyl]-2-(1H-indol-3-ylsulfonyl)acetamide chemical structure, C17H12ClF3N2O3S, CAS 850932-27-3
N-[2-Chloro-5-(trifluoromethyl)phenyl]-2-(1H-indol-3-ylsulfonyl)acetamide
CAS 850932-27-3C17H12ClF3N2O3S
N-(4-Bromophenyl)-2-((1-methyl-1H-indol-3-yl)sulfonyl)acetamide chemical structure, C17H15BrN2O3S, CAS 686743-45-3
N-(4-Bromophenyl)-2-((1-methyl-1H-indol-3-yl)sulfonyl)acetamide
CAS 686743-45-3C17H15BrN2O3S
N-(4-Bromophenyl)-2-((1-ethyl-1H-indol-3-yl)sulfonyl)acetamide chemical structure, C18H17BrN2O3S, CAS 686743-67-9
N-(4-Bromophenyl)-2-((1-ethyl-1H-indol-3-yl)sulfonyl)acetamide
CAS 686743-67-9C18H17BrN2O3S
2-((1H-Indol-3-yl)sulfonyl)-N-(4-bromophenyl)acetamide chemical structure, C16H13BrN2O3S, CAS 686743-31-7
2-((1H-Indol-3-yl)sulfonyl)-N-(4-bromophenyl)acetamide
CAS 686743-31-7C16H13BrN2O3S
N-[2-Chloro-5-(trifluoromethyl)phenyl]-2-(1-methylindol-3-yl)sulfonylacetamide chemical structure, C18H14ClF3N2O3S, CAS 686743-40-8
N-[2-Chloro-5-(trifluoromethyl)phenyl]-2-(1-methylindol-3-yl)sulfonylacetamide
CAS 686743-40-8C18H14ClF3N2O3S
N-(2,3-Dimethylphenyl)-2-[(1-methyl-1H-indol-3-yl)sulfonyl]acetamide chemical structure, C19H20N2O3S, CAS 686743-49-7
N-(2,3-Dimethylphenyl)-2-[(1-methyl-1H-indol-3-yl)sulfonyl]acetamide
CAS 686743-49-7C19H20N2O3S
N-(2,5-Dimethylphenyl)-2-((1-methyl-1H-indol-3-yl)sulfonyl)acetamide chemical structure, C19H20N2O3S, CAS 686743-50-0
N-(2,5-Dimethylphenyl)-2-((1-methyl-1H-indol-3-yl)sulfonyl)acetamide
CAS 686743-50-0C19H20N2O3S
N-(2,4-Dimethylphenyl)-2-((1-methyl-1H-indol-3-yl)sulfonyl)acetamide chemical structure, C19H20N2O3S, CAS 686743-51-1
N-(2,4-Dimethylphenyl)-2-((1-methyl-1H-indol-3-yl)sulfonyl)acetamide
CAS 686743-51-1C19H20N2O3S
N-[2-Chloro-5-(trifluoromethyl)phenyl]-2-(1-ethylindol-3-yl)sulfonylacetamide chemical structure, C19H16ClF3N2O3S, CAS 686743-62-4
N-[2-Chloro-5-(trifluoromethyl)phenyl]-2-(1-ethylindol-3-yl)sulfonylacetamide
CAS 686743-62-4C19H16ClF3N2O3S
2-(1-Ethylindol-3-yl)sulfonyl-N-(4-methoxyphenyl)acetamide chemical structure, C19H20N2O4S, CAS 850932-46-6
2-(1-Ethylindol-3-yl)sulfonyl-N-(4-methoxyphenyl)acetamide
CAS 850932-46-6C19H20N2O4S
2-[(1-Ethyl-1H-indol-3-yl)sulfonyl]-N-(4-methylphenyl)acetamide chemical structure, C19H20N2O3S, CAS 686743-68-0
2-[(1-Ethyl-1H-indol-3-yl)sulfonyl]-N-(4-methylphenyl)acetamide
CAS 686743-68-0C19H20N2O3S
2-((1-Ethyl-1H-indol-3-yl)sulfonyl)-N-(m-tolyl)acetamide chemical structure, C19H20N2O3S, CAS 686743-69-1
2-((1-Ethyl-1H-indol-3-yl)sulfonyl)-N-(m-tolyl)acetamide
CAS 686743-69-1C19H20N2O3S
N-(2,3-Dimethylphenyl)-2-((1-ethyl-1H-indol-3-yl)sulfonyl)acetamide chemical structure, C20H22N2O3S, CAS 686743-71-5
N-(2,3-Dimethylphenyl)-2-((1-ethyl-1H-indol-3-yl)sulfonyl)acetamide
CAS 686743-71-5C20H22N2O3S
N-(2,5-Dimethylphenyl)-2-((1-ethyl-1H-indol-3-yl)sulfonyl)acetamide chemical structure, C20H22N2O3S, CAS 686743-72-6
N-(2,5-Dimethylphenyl)-2-((1-ethyl-1H-indol-3-yl)sulfonyl)acetamide
CAS 686743-72-6C20H22N2O3S
N-(2,4-Dimethylphenyl)-2-((1-ethyl-1H-indol-3-yl)sulfonyl)acetamide chemical structure, C20H22N2O3S, CAS 686743-73-7
N-(2,4-Dimethylphenyl)-2-((1-ethyl-1H-indol-3-yl)sulfonyl)acetamide
CAS 686743-73-7C20H22N2O3S
N-[2-Chloro-5-(trifluoromethyl)phenyl]-2-[(1-propyl-1H-indol-3-yl)sulfonyl]acetamide chemical structure, C20H18ClF3N2O3S, CAS 850932-49-9
N-[2-Chloro-5-(trifluoromethyl)phenyl]-2-[(1-propyl-1H-indol-3-yl)sulfonyl]acetamide
CAS 850932-49-9C20H18ClF3N2O3S
N-Phenyl-2-[(1-propyl-1H-indol-3-yl)sulfonyl]acetamide chemical structure, C19H20N2O3S, CAS 850932-51-3
N-Phenyl-2-[(1-propyl-1H-indol-3-yl)sulfonyl]acetamide
CAS 850932-51-3C19H20N2O3S
Ethyl 4-[[2-(1-propylindol-3-yl)sulfonylacetyl]amino]benzoate chemical structure, C22H24N2O5S, CAS 850932-52-4
Ethyl 4-[[2-(1-propylindol-3-yl)sulfonylacetyl]amino]benzoate
CAS 850932-52-4C22H24N2O5S
N-(4-Fluorophenyl)-2-((1-propyl-1H-indol-3-yl)sulfonyl)acetamide chemical structure, C19H19FN2O3S, CAS 850932-53-5
N-(4-Fluorophenyl)-2-((1-propyl-1H-indol-3-yl)sulfonyl)acetamide
CAS 850932-53-5C19H19FN2O3S
N-(4-Bromophenyl)-2-((1-propyl-1H-indol-3-yl)sulfonyl)acetamide chemical structure, C19H19BrN2O3S, CAS 850932-54-6
N-(4-Bromophenyl)-2-((1-propyl-1H-indol-3-yl)sulfonyl)acetamide
CAS 850932-54-6C19H19BrN2O3S
2-((1-Propyl-1H-indol-3-yl)sulfonyl)-N-(m-tolyl)acetamide chemical structure, C20H22N2O3S, CAS 850932-56-8
2-((1-Propyl-1H-indol-3-yl)sulfonyl)-N-(m-tolyl)acetamide
CAS 850932-56-8C20H22N2O3S
N-(4-Ethoxyphenyl)-2-[(1-propyl-1H-indol-3-yl)sulfonyl]acetamide chemical structure, C21H24N2O4S, CAS 850932-57-9
N-(4-Ethoxyphenyl)-2-[(1-propyl-1H-indol-3-yl)sulfonyl]acetamide
CAS 850932-57-9C21H24N2O4S