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Murcko scaffold

Ring system with 4 rings and 31 atoms

15 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 31
Chemicals: 15
With full pages: 15

Scaffold SMILES

O=C(NN=Cc1cn(-c2ccccc2)nc1-c1ccccc1)C(=O)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(NN=Cc1cn(-c2ccccc2)nc1-c1ccccc1)C(=O)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 15 of 15 chemicals

N-(2,3-Dichlorophenyl)-2-oxo-2-((2E)-2-((1-phenyl-3-(4-propoxyphenyl)-1H-pyrazol-4-yl)methylene)hydrazino)acetamide chemical structure, C27H23Cl2N5O3, CAS 477732-60-8

N-(2,3-Dichlorophenyl)-2-oxo-2-((2E)-2-((1-phenyl-3-(4-propoxyphenyl)-1H-pyrazol-4-yl)methylene)hydrazino)acetamide

CAS 477732-60-8C₂₇H₂₃Cl₂N₅O₃

N-(2-Methoxyphenyl)-2-((2E)-2-{[3-(4-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}hydrazino)-2-oxoacetamide chemical structure, C26H23N5O3, CAS 477732-52-8

N-(2-Methoxyphenyl)-2-((2E)-2-{[3-(4-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}hydrazino)-2-oxoacetamide

CAS 477732-52-8C₂₆H₂₃N₅O₃

N-(2,3-Dichlorophenyl)-2-((2E)-2-{[3-(4-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}hydrazino)-2-oxoacetamide chemical structure, C25H19Cl2N5O2, CAS 477732-15-3

N-(2,3-Dichlorophenyl)-2-((2E)-2-{[3-(4-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}hydrazino)-2-oxoacetamide

CAS 477732-15-3C₂₅H₁₉Cl₂N₅O₂

N-(3,4-Dichlorophenyl)-2-((2E)-2-((3-(4-methylphenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)hydrazino)-2-oxoacetamide chemical structure, C25H19Cl2N5O2, CAS 477732-62-0

N-(3,4-Dichlorophenyl)-2-((2E)-2-((3-(4-methylphenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)hydrazino)-2-oxoacetamide

CAS 477732-62-0C₂₅H₁₉Cl₂N₅O₂

2-(2-((3-(4-Methylphenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)hydrazino)-2-oxo-N-phenylacetamide chemical structure, C25H21N5O2, CAS 881843-49-8

2-(2-((3-(4-Methylphenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)hydrazino)-2-oxo-N-phenylacetamide

CAS 881843-49-8C₂₅H₂₁N₅O₂

N-(3,4-Dichlorophenyl)-2-((2E)-2-{[3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}hydrazino)-2-oxoacetamide chemical structure, C24H16Cl2FN5O2, CAS 477732-67-5

N-(3,4-Dichlorophenyl)-2-((2E)-2-{[3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}hydrazino)-2-oxoacetamide

CAS 477732-67-5C₂₄H₁₆Cl₂FN₅O₂

N-(3,4-Dichlorophenyl)-2-oxo-2-((2E)-2-((1-phenyl-3-(4-propoxyphenyl)-1H-pyrazol-4-yl)methylene)hydrazino)acetamide chemical structure, C27H23Cl2N5O3, CAS 477731-72-9

N-(3,4-Dichlorophenyl)-2-oxo-2-((2E)-2-((1-phenyl-3-(4-propoxyphenyl)-1H-pyrazol-4-yl)methylene)hydrazino)acetamide

CAS 477731-72-9C₂₇H₂₃Cl₂N₅O₃

2-Oxo-N-phenyl-2-(2-((1-phenyl-3-(4-propoxyphenyl)-1H-pyrazol-4-yl)methylene)hydrazino)acetamide chemical structure, C27H25N5O3, CAS 882037-62-9

2-Oxo-N-phenyl-2-(2-((1-phenyl-3-(4-propoxyphenyl)-1H-pyrazol-4-yl)methylene)hydrazino)acetamide

CAS 882037-62-9C₂₇H₂₅N₅O₃

N-(4-Ethylphenyl)-2-(2-((3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)hydrazino)-2-oxoacetamide chemical structure, C26H22FN5O2, CAS 881683-63-2

N-(4-Ethylphenyl)-2-(2-((3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)hydrazino)-2-oxoacetamide

CAS 881683-63-2C₂₆H₂₂FN₅O₂

2-(2-((3-(4-Fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)hydrazino)-2-oxo-N-phenylacetamide chemical structure, C24H18FN5O2, CAS 881683-69-8

2-(2-((3-(4-Fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)hydrazino)-2-oxo-N-phenylacetamide

CAS 881683-69-8C₂₄H₁₈FN₅O₂

N-(4-Methoxyphenyl)-2-(2-((3-(4-methylphenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)hydrazino)-2-oxoacetamide chemical structure, C26H23N5O3, CAS 881840-00-2

N-(4-Methoxyphenyl)-2-(2-((3-(4-methylphenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)hydrazino)-2-oxoacetamide

CAS 881840-00-2C₂₆H₂₃N₅O₃

2-(2-((3-(4-Fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)hydrazino)-N-(4-methylphenyl)-2-oxoacetamide chemical structure, C25H20FN5O2, CAS 881840-08-0

2-(2-((3-(4-Fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)hydrazino)-N-(4-methylphenyl)-2-oxoacetamide

CAS 881840-08-0C₂₅H₂₀FN₅O₂

2-(2-((3-(4-Fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)hydrazino)-N-(4-methoxyphenyl)-2-oxoacetamide chemical structure, C25H20FN5O3, CAS 881840-12-6

2-(2-((3-(4-Fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)hydrazino)-N-(4-methoxyphenyl)-2-oxoacetamide

CAS 881840-12-6C₂₅H₂₀FN₅O₃

N-(3-Methoxyphenyl)-2-oxo-2-(2-((1-phenyl-3-(4-propoxyphenyl)-1H-pyrazol-4-yl)methylene)hydrazino)acetamide chemical structure, C28H27N5O4, CAS 881843-47-6

N-(3-Methoxyphenyl)-2-oxo-2-(2-((1-phenyl-3-(4-propoxyphenyl)-1H-pyrazol-4-yl)methylene)hydrazino)acetamide

CAS 881843-47-6C₂₈H₂₇N₅O₄

N-(4-Methoxyphenyl)-2-oxo-2-(2-((1-phenyl-3-(4-propoxyphenyl)-1H-pyrazol-4-yl)methylene)hydrazino)acetamide chemical structure, C28H27N5O4, CAS 881843-48-7

N-(4-Methoxyphenyl)-2-oxo-2-(2-((1-phenyl-3-(4-propoxyphenyl)-1H-pyrazol-4-yl)methylene)hydrazino)acetamide

CAS 881843-48-7C₂₈H₂₇N₅O₄