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Murcko scaffold

Ring system with 3 rings and 14 atoms

19 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
14
Chemicals
19
With full pages
5
Scaffold SMILES

c1csc(-c2ccc3cn[nH]c3n2)c1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1csc(-c2ccc3cn[nH]c3n2)c1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 19 of 19 chemicals

1,3-Dimethyl-6-(2-thienyl)-4-(trifluoromethyl)-1H-pyrazolo(3,4-B)pyridine chemical structure, C13H10F3N3S, CAS 633315-39-6
1,3-Dimethyl-6-(2-thienyl)-4-(trifluoromethyl)-1H-pyrazolo(3,4-B)pyridine
CAS 633315-39-6C13H10F3N3S
1-(Propan-2-yl)-6-(thiophen-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid chemical structure, C14H13N3O2S, CAS 879576-89-3
1-(Propan-2-yl)-6-(thiophen-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid
CAS 879576-89-3C14H13N3O2S
1-Ethyl-6-(thiophen-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid chemical structure, C13H11N3O2S, CAS 923919-56-6
1-Ethyl-6-(thiophen-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid
CAS 923919-56-6C13H11N3O2S
6-(5-Methylthiophen-2-yl)-1-(propan-2-yl)-1H-pyrazolo(3,4-b)pyridine-4-carboxylic acid chemical structure, C15H15N3O2S, CAS 924232-60-0
6-(5-Methylthiophen-2-yl)-1-(propan-2-yl)-1H-pyrazolo(3,4-b)pyridine-4-carboxylic acid
CAS 924232-60-0C15H15N3O2S
1,3-Dimethyl-6-(thiophen-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid chemical structure, C13H11N3O2S, CAS 893645-77-7
1,3-Dimethyl-6-(thiophen-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid
CAS 893645-77-7C13H11N3O2S
Methyl 1-(2-cyanoethyl)-3-methyl-6-(thiophen-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate chemical structure, C16H14N4O2S, CAS 924424-39-5
Methyl 1-(2-cyanoethyl)-3-methyl-6-(thiophen-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate
CAS 924424-39-5C16H14N4O2S
1-Ethyl-3-methyl-6-(5-methyl-2-thienyl)-4-(trifluoromethyl)-1H-pyrazolo[3,4-B]pyridine chemical structure, C15H14F3N3S, CAS 832741-73-8
1-Ethyl-3-methyl-6-(5-methyl-2-thienyl)-4-(trifluoromethyl)-1H-pyrazolo[3,4-B]pyridine
CAS 832741-73-8C15H14F3N3S
6-(5-Chloro-2-thienyl)-1,3-dimethyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-B]pyridine chemical structure, C13H9ClF3N3S, CAS 834896-59-2
6-(5-Chloro-2-thienyl)-1,3-dimethyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-B]pyridine
CAS 834896-59-2C13H9ClF3N3S
1-Butyl-3-methyl-6-(5-methylthiophen-2-yl)-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine chemical structure, C17H18F3N3S, CAS 866814-50-8
1-Butyl-3-methyl-6-(5-methylthiophen-2-yl)-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine
CAS 866814-50-8C17H18F3N3S
1-Butyl-3-methyl-6-(thiophen-2-yl)-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine chemical structure, C16H16F3N3S, CAS 866818-32-8
1-Butyl-3-methyl-6-(thiophen-2-yl)-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine
CAS 866818-32-8C16H16F3N3S
1-Butyl-4-(difluoromethyl)-3-methyl-6-(thiophen-2-yl)-1H-pyrazolo[3,4-b]pyridine chemical structure, C16H17F2N3S, CAS 866818-86-2
1-Butyl-4-(difluoromethyl)-3-methyl-6-(thiophen-2-yl)-1H-pyrazolo[3,4-b]pyridine
CAS 866818-86-2C16H17F2N3S
Methyl 1-ethyl-6-(thiophen-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate chemical structure, C14H13N3O2S, CAS 932139-18-9
Methyl 1-ethyl-6-(thiophen-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate
CAS 932139-18-9C14H13N3O2S
Ethyl [6-(5-ethylthiophen-2-yl)-3-methyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl]acetate chemical structure, C18H18F3N3O2S, CAS 1011356-48-1
Ethyl [6-(5-ethylthiophen-2-yl)-3-methyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl]acetate
CAS 1011356-48-1C18H18F3N3O2S
Methyl 1,3-dimethyl-6-(thiophen-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate chemical structure, C14H13N3O2S, CAS 1011359-89-9
Methyl 1,3-dimethyl-6-(thiophen-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate
CAS 1011359-89-9C14H13N3O2S
2-(3-Methyl-6-(thiophen-2-yl)-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acid chemical structure, C14H10F3N3O2S, CAS 937605-82-8
2-(3-Methyl-6-(thiophen-2-yl)-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acid
CAS 937605-82-8C14H10F3N3O2S
[4-(Difluoromethyl)-3-methyl-6-(thiophen-2-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid chemical structure, C14H11F2N3O2S, CAS 937607-12-0
[4-(Difluoromethyl)-3-methyl-6-(thiophen-2-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid
CAS 937607-12-0C14H11F2N3O2S
6-(5-Chloro-2-thienyl)-1-ethyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid chemical structure, C13H10ClN3O2S, CAS 1041522-21-7
6-(5-Chloro-2-thienyl)-1-ethyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid
CAS 1041522-21-7C13H10ClN3O2S
N-(1-Cyanopropyl)-1-propan-2-yl-6-thiophen-2-ylpyrazolo[3,4-b]pyridine-4-carboxamide chemical structure, C18H19N5OS, CAS 1333648-08-0
N-(1-Cyanopropyl)-1-propan-2-yl-6-thiophen-2-ylpyrazolo[3,4-b]pyridine-4-carboxamide
CAS 1333648-08-0C18H19N5OS
N-(1-Cyanoethyl)-1-(propan-2-yl)-6-(thiophen-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxamide chemical structure, C17H17N5OS, CAS 1427920-48-6
N-(1-Cyanoethyl)-1-(propan-2-yl)-6-(thiophen-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxamide
CAS 1427920-48-6C17H17N5OS