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Murcko scaffold

Ring system with 3 rings and 14 atoms

28 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
14
Chemicals
28
With full pages
7
Scaffold SMILES

c1coc(-c2ccn3nccc3n2)c1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1coc(-c2ccn3nccc3n2)c1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 28 of 28 chemicals

Ethyl 5-(furan-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate chemical structure, C14H10F3N3O3, CAS 333762-39-3
Ethyl 5-(furan-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate
CAS 333762-39-3C14H10F3N3O3
Isopropyl 3-bromo-5-(5-bromo-2-furyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylate chemical structure, C15H10Br2F3N3O3, CAS 313396-94-0
Isopropyl 3-bromo-5-(5-bromo-2-furyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS 313396-94-0C15H10Br2F3N3O3
Methyl 3-bromo-5-(5-bromofuran-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylate chemical structure, C13H6Br2F3N3O3, CAS 313396-90-6
Methyl 3-bromo-5-(5-bromofuran-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS 313396-90-6C13H6Br2F3N3O3
5-(Furan-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid chemical structure, C12H6F3N3O3, CAS 313968-60-4
5-(Furan-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid
CAS 313968-60-4C12H6F3N3O3
7-[Chloro(difluoro)methyl]-5-(furan-2-yl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid chemical structure, C12H6ClF2N3O3, CAS 445473-38-1
7-[Chloro(difluoro)methyl]-5-(furan-2-yl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid
CAS 445473-38-1C12H6ClF2N3O3
Methyl 5-(2-furyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate chemical structure, C13H8F3N3O3, CAS 5848-40-8
Methyl 5-(2-furyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate
CAS 5848-40-8C13H8F3N3O3
5-(2-Furyl)-2-methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine chemical structure, C12H8F3N3O, CAS 439111-88-3
5-(2-Furyl)-2-methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine
CAS 439111-88-3C12H8F3N3O
Ethyl 3-chloro-5-(furan-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylate chemical structure, C14H9ClF3N3O3, CAS 312934-97-7
Ethyl 3-chloro-5-(furan-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS 312934-97-7C14H9ClF3N3O3
3-Chloro-5-(2-furanyl)-N-propan-2-yl-7-(trifluoromethyl)-2-pyrazolo[1,5-a]pyrimidinecarboxamide chemical structure, C15H12ClF3N4O2, CAS 334499-24-0
3-Chloro-5-(2-furanyl)-N-propan-2-yl-7-(trifluoromethyl)-2-pyrazolo[1,5-a]pyrimidinecarboxamide
CAS 334499-24-0C15H12ClF3N4O2
5-(Furan-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide chemical structure, C12H7F3N4O2, CAS 5845-72-7
5-(Furan-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
CAS 5845-72-7C12H7F3N4O2
3-Bromo-5-(furan-2-yl)-2-methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine chemical structure, C12H7BrF3N3O, CAS 675188-61-1
3-Bromo-5-(furan-2-yl)-2-methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine
CAS 675188-61-1C12H7BrF3N3O
3-Chloro-5-(5-chloro-2-furyl)-2-methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine chemical structure, C12H6Cl2F3N3O, CAS 439120-59-9
3-Chloro-5-(5-chloro-2-furyl)-2-methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine
CAS 439120-59-9C12H6Cl2F3N3O
3-Chloro-5-(furan-2-yl)-2-methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine chemical structure, C12H7ClF3N3O, CAS 478249-06-8
3-Chloro-5-(furan-2-yl)-2-methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine
CAS 478249-06-8C12H7ClF3N3O
3-Chloro-5-(furan-2-yl)-N-(2-methoxyethyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide chemical structure, C15H12ClF3N4O3, CAS 313390-52-2
3-Chloro-5-(furan-2-yl)-N-(2-methoxyethyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide
CAS 313390-52-2C15H12ClF3N4O3
5-(Furan-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide chemical structure, C12H7F3N4O2, CAS 312634-62-1
5-(Furan-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide
CAS 312634-62-1C12H7F3N4O2
3-Chloro-5-(furan-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carbonyl chloride chemical structure, C12H4Cl2F3N3O2, CAS 524036-10-0
3-Chloro-5-(furan-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carbonyl chloride
CAS 524036-10-0C12H4Cl2F3N3O2
Ethyl 5-(furan-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylate chemical structure, C14H10F3N3O3, CAS 352213-03-7
Ethyl 5-(furan-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS 352213-03-7C14H10F3N3O3
3-Chloro-N-[3-(diethylamino)propyl]-5-(furan-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide chemical structure, C19H21ClF3N5O2, CAS 5821-11-4
3-Chloro-N-[3-(diethylamino)propyl]-5-(furan-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide
CAS 5821-11-4C19H21ClF3N5O2
5-(2-Furanyl)-N-2-propen-1-yl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide chemical structure, C15H11F3N4O2, CAS 348163-76-8
5-(2-Furanyl)-N-2-propen-1-yl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide
CAS 348163-76-8C15H11F3N4O2
5-(2-Furanyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile chemical structure, C12H5F3N4O, CAS 827588-26-1
5-(2-Furanyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile
CAS 827588-26-1C12H5F3N4O
Methyl 7-(difluoromethyl)-5-(furan-2-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylate chemical structure, C13H9F2N3O3, CAS 676249-26-6
Methyl 7-(difluoromethyl)-5-(furan-2-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylate
CAS 676249-26-6C13H9F2N3O3
5-(Furan-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carbonyl chloride chemical structure, C12H5ClF3N3O2, CAS 848422-53-7
5-(Furan-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carbonyl chloride
CAS 848422-53-7C12H5ClF3N3O2
7-Chloro-5-(2-furyl)pyrazolo[1,5-a]pyrimidine chemical structure, C10H6ClN3O, CAS 183958-54-5
7-Chloro-5-(2-furyl)pyrazolo[1,5-a]pyrimidine
CAS 183958-54-5C10H6ClN3O
3-Bromo-7-chloro-5-(furan-2-yl)pyrazolo[1,5-a]pyrimidine chemical structure, C10H5BrClN3O, CAS 674297-92-8
3-Bromo-7-chloro-5-(furan-2-yl)pyrazolo[1,5-a]pyrimidine
CAS 674297-92-8C10H5BrClN3O