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Murcko scaffold

Ring system with 3 rings and 25 atoms

8 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
25
Chemicals
8
With full pages
1
Scaffold SMILES

O=C(CCCN1C(=O)C(=Cc2ccccc2)SC1=S)Nc1nccs1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CCCN1C(=O)C(=Cc2ccccc2)SC1=S)Nc1nccs1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 8 of 8 chemicals

(Z)-4-(5-Benzylidene-4-oxo-2-thioxothiazolidin-3-yl)-N-(thiazol-2-yl)butanamide chemical structure, C17H15N3O2S3, CAS 300378-88-5
(Z)-4-(5-Benzylidene-4-oxo-2-thioxothiazolidin-3-yl)-N-(thiazol-2-yl)butanamide
CAS 300378-88-5C17H15N3O2S3
4-[5-(4-Bromobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-N-(1,3-thiazol-2-yl)butanamide chemical structure, C17H14BrN3O2S3, CAS 304894-11-9
4-[5-(4-Bromobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-N-(1,3-thiazol-2-yl)butanamide
CAS 304894-11-9C17H14BrN3O2S3
4-[5-(4-Ethylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-N-1,3-thiazol-2-ylbutanamide chemical structure, C19H19N3O2S3, CAS 1164554-17-9
4-[5-(4-Ethylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-N-1,3-thiazol-2-ylbutanamide
CAS 1164554-17-9C19H19N3O2S3
4-[(5Z)-5-[(4-Chlorophenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-N-(1,3-thiazol-2-yl)butanamide chemical structure, C17H14ClN3O2S3, CAS 304894-09-5
4-[(5Z)-5-[(4-Chlorophenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-N-(1,3-thiazol-2-yl)butanamide
CAS 304894-09-5C17H14ClN3O2S3
Methyl 4-[(Z)-[4-oxo-2-sulfanylidene-3-[3-(1,3-thiazol-2-ylcarbamoyl)propyl]thiazolidin-5-ylidene]methyl]benzoate chemical structure, C19H17N3O4S3, CAS 6069-89-2
Methyl 4-[(Z)-[4-oxo-2-sulfanylidene-3-[3-(1,3-thiazol-2-ylcarbamoyl)propyl]thiazolidin-5-ylidene]methyl]benzoate
CAS 6069-89-2C19H17N3O4S3
4-[(5Z)-5-(4-Ethylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-N-(4-methyl-1,3-thiazol-2-yl)butanamide chemical structure, C20H21N3O2S3, CAS 315243-59-5
4-[(5Z)-5-(4-Ethylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-N-(4-methyl-1,3-thiazol-2-yl)butanamide
CAS 315243-59-5C20H21N3O2S3
4-[(5Z)-5-[(3-Methoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-N-(1,3-thiazol-2-yl)butanamide chemical structure, C18H17N3O3S3, CAS 476667-58-0
4-[(5Z)-5-[(3-Methoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-N-(1,3-thiazol-2-yl)butanamide
CAS 476667-58-0C18H17N3O3S3
(Z)-4-(5-(3-Methoxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-N-(4-methylthiazol-2-yl)butanamide chemical structure, C19H19N3O3S3, CAS 476667-60-4
(Z)-4-(5-(3-Methoxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-N-(4-methylthiazol-2-yl)butanamide
CAS 476667-60-4C19H19N3O3S3