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Murcko scaffold

Ring system with 3 rings and 26 atoms

11 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 26
Chemicals: 11
With full pages: 9

Scaffold SMILES

O=C(CSc1nnc(-c2ccccc2)[nH]1)NN=CC=Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(CSc1nnc(-c2ccccc2)[nH]1)NN=CC=Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 11 of 11 chemicals

2-[[4-Ethyl-5-(4-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(E)-[(E)-3-phenylprop-2-enylidene]amino]acetamide chemical structure, C22H23N5OS, CAS 497824-52-9

2-[[4-Ethyl-5-(4-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(E)-[(E)-3-phenylprop-2-enylidene]amino]acetamide

CAS 497824-52-9C₂₂H₂₃N₅OS

2-[[4-Ethyl-5-(4-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(E)-[(E)-2-methyl-3-phenylprop-2-enylidene]amino]acetamide chemical structure, C23H25N5OS, CAS 497824-53-0

2-[[4-Ethyl-5-(4-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(E)-[(E)-2-methyl-3-phenylprop-2-enylidene]amino]acetamide

CAS 497824-53-0C₂₃H₂₅N₅OS

2-((4-ET-5-PH-4H-1,2,4-Triazol-3-yl)thio)N'-(3-PH-2-propenylidene)acetohydrazide chemical structure, C21H21N5OS, CAS 361165-42-6

2-((4-ET-5-PH-4H-1,2,4-Triazol-3-yl)thio)N'-(3-PH-2-propenylidene)acetohydrazide

CAS 361165-42-6C₂₁H₂₁N₅OS

2-((4-Ethyl-5-(4-methoxyphenyl)-4H-1,2,4-triazol-3-yl)sulfanyl)-N'-((E,2E)-3-(2-nitrophenyl)-2-propenylidene)acetohydrazide chemical structure, C22H22N6O4S, CAS 308096-11-9

2-((4-Ethyl-5-(4-methoxyphenyl)-4H-1,2,4-triazol-3-yl)sulfanyl)-N'-((E,2E)-3-(2-nitrophenyl)-2-propenylidene)acetohydrazide

CAS 308096-11-9C₂₂H₂₂N₆O₄S

2-{[4-Ethyl-5-(4-methoxyphenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N'-[(E,2E)-3-(2-methoxyphenyl)-2-propenylidene]acetohydrazide chemical structure, C23H25N5O3S, CAS 308096-16-4

2-{[4-Ethyl-5-(4-methoxyphenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N'-[(E,2E)-3-(2-methoxyphenyl)-2-propenylidene]acetohydrazide

CAS 308096-16-4C₂₃H₂₅N₅O₃S

2-{[4-Ethyl-5-(4-methoxyphenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N'-[(E,2E)-3-phenyl-2-propenylidene]acetohydrazide chemical structure, C22H23N5O2S, CAS 308096-14-2

2-{[4-Ethyl-5-(4-methoxyphenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N'-[(E,2E)-3-phenyl-2-propenylidene]acetohydrazide

CAS 308096-14-2C₂₂H₂₃N₅O₂S

2-{[4-Ethyl-5-(4-methoxyphenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N'-[(E,2E)-2-methyl-3-phenyl-2-propenylidene]acetohydrazide chemical structure, C23H25N5O2S, CAS 303203-25-0

2-{[4-Ethyl-5-(4-methoxyphenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N'-[(E,2E)-2-methyl-3-phenyl-2-propenylidene]acetohydrazide

CAS 303203-25-0C₂₃H₂₅N₅O₂S

N'-[(E,2Z)-2-Bromo-3-phenyl-2-propenylidene]-2-{[4-ethyl-5-(4-methoxyphenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetohydrazide chemical structure, C22H22BrN5O2S, CAS 307975-59-3

N'-[(E,2Z)-2-Bromo-3-phenyl-2-propenylidene]-2-{[4-ethyl-5-(4-methoxyphenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetohydrazide

CAS 307975-59-3C₂₂H₂₂BrN₅O₂S

2-{[5-(4-Bromophenyl)-4-(2-methyl-2-propenyl)-4H-1,2,4-triazol-3-yl]sulf anyl}-N'-[(E,2E)-2-methyl-3-phenyl-2-propenylidene]acetohydrazide chemical structure, C24H24BrN5OS, CAS 330838-41-0

2-{[5-(4-Bromophenyl)-4-(2-methyl-2-propenyl)-4H-1,2,4-triazol-3-yl]sulf anyl}-N'-[(E,2E)-2-methyl-3-phenyl-2-propenylidene]acetohydrazide

CAS 330838-41-0C₂₄H₂₄BrN₅OS

2-{[5-(4-Bromophenyl)-4-(2-methyl-2-propenyl)-4H-1,2,4-triazol-3-yl]sulf anyl}-N'-[(E,2Z)-2-bromo-3-phenyl-2-propenylidene]acetohydrazide chemical structure, C23H21Br2N5OS, CAS 330838-54-5

2-{[5-(4-Bromophenyl)-4-(2-methyl-2-propenyl)-4H-1,2,4-triazol-3-yl]sulf anyl}-N'-[(E,2Z)-2-bromo-3-phenyl-2-propenylidene]acetohydrazide

CAS 330838-54-5C₂₃H₂₁Br₂N₅OS

2-{[5-(4-Bromophenyl)-4-(2-methyl-2-propenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N'-[(E,2E)-3-phenyl-2-propenylidene]acetohydrazide chemical structure, C23H22BrN5OS, CAS 330838-49-8

2-{[5-(4-Bromophenyl)-4-(2-methyl-2-propenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N'-[(E,2E)-3-phenyl-2-propenylidene]acetohydrazide

CAS 330838-49-8C₂₃H₂₂BrN₅OS