Murcko scaffold
Ring system with 5 rings and 31 atoms
23 chemicals on CompoundList share this ring system.
- Rings
- 5
- Scaffold atoms
- 31
- Chemicals
- 23
- With full pages
- 9
Scaffold SMILES
O=C1C(=Cc2cn(-c3ccccc3)nc2-c2ccccc2)SC(=S)N1C1CCCCC1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 23 of 23 chemicals
![(5Z)-3-Cyclohexyl-5-{[3-(4-methoxy-2-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-thioxo-1,3-thiazolidin-4-one chemical structure, C27H27N3O2S2, CAS 955876-25-2](/s/APJPGTOAVCLLQT-JLPGSUDCSA-N.svg)
(5Z)-3-Cyclohexyl-5-{[3-(4-methoxy-2-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-thioxo-1,3-thiazolidin-4-one
CAS 955876-25-2C27H27N3O2S2
![(5Z)-3-Cyclohexyl-5-{[3-(4-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-thioxo-1,3-thiazolidin-4-one chemical structure, C26H25N3OS2, CAS 313272-71-8](/s/JWJOKPAWLZTGFL-KQWNVCNZSA-N.svg)
(5Z)-3-Cyclohexyl-5-{[3-(4-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-thioxo-1,3-thiazolidin-4-one
CAS 313272-71-8C26H25N3OS2
![(5Z)-3-Cyclohexyl-5-({1-phenyl-3-[4-(propylsulfanyl)phenyl]-1H-pyrazol-4-yl}methylidene)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C28H29N3OS3, CAS 1008878-26-9](/s/KMDBOZWICGJUEX-BWAHOGKJSA-N.svg)
(5Z)-3-Cyclohexyl-5-({1-phenyl-3-[4-(propylsulfanyl)phenyl]-1H-pyrazol-4-yl}methylidene)-2-thioxo-1,3-thiazolidin-4-one
CAS 1008878-26-9C28H29N3OS3
![(5Z)-3-Cyclohexyl-5-({3-[4-(ethylsulfanyl)phenyl]-1-phenyl-1H-pyrazol-4-yl}methylidene)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C27H27N3OS3, CAS 1009186-40-6](/s/HKHUBHRTAMGAJJ-ULJHMMPZSA-N.svg)
(5Z)-3-Cyclohexyl-5-({3-[4-(ethylsulfanyl)phenyl]-1-phenyl-1H-pyrazol-4-yl}methylidene)-2-thioxo-1,3-thiazolidin-4-one
CAS 1009186-40-6C27H27N3OS3
![(5Z)-3-Cyclohexyl-5-{[3-(4-ethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-thioxo-1,3-thiazolidin-4-one chemical structure, C27H27N3O2S2, CAS 312314-33-3](/s/WVDUTPGJPKWRNQ-ULJHMMPZSA-N.svg)
(5Z)-3-Cyclohexyl-5-{[3-(4-ethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-thioxo-1,3-thiazolidin-4-one
CAS 312314-33-3C27H27N3O2S2
![(5Z)-3-Cyclohexyl-5-{[3-(4-isopropoxy-3-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-2-thioxo-1,3-thiazolidin-4-one chemical structure, C29H31N3O2S2, CAS 383371-64-0](/s/JLLBMXKSVASNPJ-ONUIUJJFSA-N.svg)
(5Z)-3-Cyclohexyl-5-{[3-(4-isopropoxy-3-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-2-thioxo-1,3-thiazolidin-4-one
CAS 383371-64-0C29H31N3O2S2
![(5Z)-3-Cyclohexyl-5-({3-[2-methyl-4-(2-methylpropoxy)phenyl]-1-phenyl-1H-pyrazol-4-yl}methylidene)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C30H33N3O2S2, CAS 956043-26-8](/s/DAOXBAAGPHNNHR-PKAZHMFMSA-N.svg)
(5Z)-3-Cyclohexyl-5-({3-[2-methyl-4-(2-methylpropoxy)phenyl]-1-phenyl-1H-pyrazol-4-yl}methylidene)-2-thioxo-1,3-thiazolidin-4-one
CAS 956043-26-8C30H33N3O2S2
![(5Z)-3-Cyclohexyl-5-{[3-(2-methyl-4-propoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-2-thioxo-1,3-thiazolidin-4-one chemical structure, C29H31N3O2S2, CAS 955863-30-6](/s/XUWQSISAQFGVLJ-ITYLOYPMSA-N.svg)
(5Z)-3-Cyclohexyl-5-{[3-(2-methyl-4-propoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-2-thioxo-1,3-thiazolidin-4-one
CAS 955863-30-6C29H31N3O2S2
![(5Z)-3-Cyclohexyl-5-{[3-(4-isobutoxy-3-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-2-thioxo-1,3-thiazolidin-4-one chemical structure, C30H33N3O2S2, CAS 623934-92-9](/s/DDPPCIFXZOQSLL-PKAZHMFMSA-N.svg)
(5Z)-3-Cyclohexyl-5-{[3-(4-isobutoxy-3-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-2-thioxo-1,3-thiazolidin-4-one
CAS 623934-92-9C30H33N3O2S2
![3-Cyclohexyl-5-({3-[4-(2-methylpropoxy)phenyl]-1-phenylpyrazol-4-yl}methylene)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C29H31N3O2S2, CAS 955873-02-6](/s/GKLZLEJUWXAYIC-ONUIUJJFSA-N.svg)
3-Cyclohexyl-5-({3-[4-(2-methylpropoxy)phenyl]-1-phenylpyrazol-4-yl}methylene)-2-thioxo-1,3-thiazolidin-4-one
CAS 955873-02-6C29H31N3O2S2
![(5Z)-3-Cyclohexyl-5-({3-[2-methyl-4-(propan-2-yloxy)phenyl]-1-phenyl-1H-pyrazol-4-yl}methylidene)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C29H31N3O2S2, CAS 956783-10-1](/s/JBNHUKUMQRGFHI-ONUIUJJFSA-N.svg)
(5Z)-3-Cyclohexyl-5-({3-[2-methyl-4-(propan-2-yloxy)phenyl]-1-phenyl-1H-pyrazol-4-yl}methylidene)-2-thioxo-1,3-thiazolidin-4-one
CAS 956783-10-1C29H31N3O2S2
![(5Z)-5-{[3-(4-Butoxy-2-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-3-cyclohexyl-2-thioxo-1,3-thiazolidin-4-one chemical structure, C30H33N3O2S2, CAS 955888-90-1](/s/QEZPRAOSXQIWLQ-DIBXZPPDSA-N.svg)
(5Z)-5-{[3-(4-Butoxy-2-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-3-cyclohexyl-2-thioxo-1,3-thiazolidin-4-one
CAS 955888-90-1C30H33N3O2S2
![(5Z)-3-Cyclohexyl-5-{[3-(3,4-dimethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-2-thioxo-1,3-thiazolidin-4-one chemical structure, C27H27N3O3S2, CAS 623935-66-0](/s/QNHHUFWSJALLJJ-JLPGSUDCSA-N.svg)
(5Z)-3-Cyclohexyl-5-{[3-(3,4-dimethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-2-thioxo-1,3-thiazolidin-4-one
CAS 623935-66-0C27H27N3O3S2
![(5Z)-3-Cyclohexyl-5-({3-[4-(hexyloxy)phenyl]-1-phenyl-1H-pyrazol-4-yl}methylidene)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C31H35N3O2S2, CAS 955875-02-2](/s/UYFLZQZHJANCQP-HFTWOUSFSA-N.svg)
(5Z)-3-Cyclohexyl-5-({3-[4-(hexyloxy)phenyl]-1-phenyl-1H-pyrazol-4-yl}methylidene)-2-thioxo-1,3-thiazolidin-4-one
CAS 955875-02-2C31H35N3O2S2
![(5Z)-3-Cyclohexyl-5-({3-[2-methyl-4-(prop-2-en-1-yloxy)phenyl]-1-phenyl-1H-pyrazol-4-yl}methylidene)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C29H29N3O2S2, CAS 955889-59-5](/s/UASUAGWQQFUDJH-ITYLOYPMSA-N.svg)
(5Z)-3-Cyclohexyl-5-({3-[2-methyl-4-(prop-2-en-1-yloxy)phenyl]-1-phenyl-1H-pyrazol-4-yl}methylidene)-2-thioxo-1,3-thiazolidin-4-one
CAS 955889-59-5C29H29N3O2S2
(5Z)-3-Cyclohexyl-5-((1,3-diphenyl-1H-pyrazol-4-yl)methylene)-2-thioxo-1,3-thiazolidin-4-one
CAS 623940-37-4C25H23N3OS2
(5Z)-3-Cyclohexyl-5-((3-(3-fluoro-4-methylphenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)-2-thioxo-1,3-thiazolidin-4-one
CAS 623940-32-9C26H24FN3OS2
![(5Z)-5-{[3-(4-Chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-3-cyclohexyl-2-thioxo-1,3-thiazolidin-4-one chemical structure, C25H22ClN3OS2, CAS 623935-48-8](/s/QCGCGCBAGLLHKM-JCMHNJIXSA-N.svg)
(5Z)-5-{[3-(4-Chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-3-cyclohexyl-2-thioxo-1,3-thiazolidin-4-one
CAS 623935-48-8C25H22ClN3OS2
![(5Z)-3-Cyclohexyl-5-{[3-(4-ethoxy-3-nitrophenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-2-thioxo-1,3-thiazolidin-4-one chemical structure, C27H26N4O4S2, CAS 623940-43-2](/s/BAJAHCVUEJJPDM-JLPGSUDCSA-N.svg)
(5Z)-3-Cyclohexyl-5-{[3-(4-ethoxy-3-nitrophenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-2-thioxo-1,3-thiazolidin-4-one
CAS 623940-43-2C27H26N4O4S2
(5Z)-3-Cyclohexyl-5-((3-(3-isobutoxy-2-methylphenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)-2-thioxo-1,3-thiazolidin-4-one
CAS 623936-35-6C30H33N3O2S2
![(5Z)-5-({3-[4-(Butylsulfanyl)phenyl]-1-phenyl-1H-pyrazol-4-yl}methylidene)-3-cyclohexyl-2-thioxo-1,3-thiazolidin-4-one chemical structure, C29H31N3OS3, CAS 1009434-43-8](/s/SGMFGMXDUAUFIN-XHPQRKPJSA-N.svg)
(5Z)-5-({3-[4-(Butylsulfanyl)phenyl]-1-phenyl-1H-pyrazol-4-yl}methylidene)-3-cyclohexyl-2-thioxo-1,3-thiazolidin-4-one
CAS 1009434-43-8C29H31N3OS3
(5Z)-5-((3-(3-Chloro-4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)-3-cyclohexyl-2-thioxo-1,3-thiazolidin-4-one
CAS 624723-97-3C26H24ClN3O2S2
![(5Z)-3-Cyclohexyl-5-{[3-(3-fluoro-4-propoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-2-thioxo-1,3-thiazolidin-4-one chemical structure, C28H28FN3O2S2, CAS 623940-38-5](/s/UVIJLWQTKZFRAH-UQQQWYQISA-N.svg)
(5Z)-3-Cyclohexyl-5-{[3-(3-fluoro-4-propoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-2-thioxo-1,3-thiazolidin-4-one
CAS 623940-38-5C28H28FN3O2S2
Related scaffolds
Same ring framework with different atoms or bond orders
