Murcko scaffold
Ring system with 5 rings and 30 atoms
26 chemicals on CompoundList share this ring system.
- Rings
- 5
- Scaffold atoms
- 30
- Chemicals
- 26
- With full pages
- 2
Scaffold SMILES
O=C1N=C(N2CCOCC2)SC1=Cc1cn(-c2ccccc2)nc1-c1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 26 of 26 chemicals
![(5Z)-5-{[3-(4-Methoxy-3-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-2-(4-morpholinyl)-1,3-thiazol-4(5H)-one chemical structure, C25H24N4O3S, CAS 623935-37-5](/s/MRHIRDGTGIVFTR-JCMHNJIXSA-N.svg)
(5Z)-5-{[3-(4-Methoxy-3-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-2-(4-morpholinyl)-1,3-thiazol-4(5H)-one
CAS 623935-37-5C25H24N4O3S
![(5E)-5-[[3-(3-Methyl-4-propoxyphenyl)-1-phenylpyrazol-4-yl]methylidene]-2-morpholin-4-yl-1,3-thiazol-4-one chemical structure, C27H28N4O3S, CAS 380156-53-6](/s/SHRSYRMPVYGEIF-JJIBRWJFSA-N.svg)
(5E)-5-[[3-(3-Methyl-4-propoxyphenyl)-1-phenylpyrazol-4-yl]methylidene]-2-morpholin-4-yl-1,3-thiazol-4-one
CAS 380156-53-6C27H28N4O3S
![(5Z)-5-({3-[4-(Butylsulfanyl)phenyl]-1-phenyl-1H-pyrazol-4-yl}methylidene)-2-(morpholin-4-yl)-1,3-thiazol-4(5H)-one chemical structure, C27H28N4O2S2, CAS 1008877-66-4](/s/JPPSFTOHCKZYAV-MOHJPFBDSA-N.svg)
(5Z)-5-({3-[4-(Butylsulfanyl)phenyl]-1-phenyl-1H-pyrazol-4-yl}methylidene)-2-(morpholin-4-yl)-1,3-thiazol-4(5H)-one
CAS 1008877-66-4C27H28N4O2S2
![5-((Z)-1-{3-[4-(Ethylsulfanyl)phenyl]-1-phenyl-1H-pyrazol-4-yl}methylidene)-2-morpholino-1,3-thiazol-4-one chemical structure, C25H24N4O2S2, CAS 1008880-17-8](/s/NIHBRKGFBMKJCS-JWGURIENSA-N.svg)
5-((Z)-1-{3-[4-(Ethylsulfanyl)phenyl]-1-phenyl-1H-pyrazol-4-yl}methylidene)-2-morpholino-1,3-thiazol-4-one
CAS 1008880-17-8C25H24N4O2S2
![2-Morpholino-5-((Z)-1-{1-phenyl-3-[4-(propylsulfanyl)phenyl]-1H-pyrazol-4-yl}methylidene)-1,3-thiazol-4-one chemical structure, C26H26N4O2S2, CAS 1009186-89-3](/s/BBSYVSWBOPKSQH-QJOMJCCJSA-N.svg)
2-Morpholino-5-((Z)-1-{1-phenyl-3-[4-(propylsulfanyl)phenyl]-1H-pyrazol-4-yl}methylidene)-1,3-thiazol-4-one
CAS 1009186-89-3C26H26N4O2S2
![(5Z)-5-{[3-(3-Chloro-4-propoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-(morpholin-4-yl)-1,3-thiazol-4(5H)-one chemical structure, C26H25ClN4O3S, CAS 1008881-10-4](/s/GRRFEIIVLKMBJC-KQWNVCNZSA-N.svg)
(5Z)-5-{[3-(3-Chloro-4-propoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-(morpholin-4-yl)-1,3-thiazol-4(5H)-one
CAS 1008881-10-4C26H25ClN4O3S
![(5E)-5-[[3-(3-Methyl-4-prop-2-enoxyphenyl)-1-phenylpyrazol-4-yl]methylidene]-2-morpholin-4-yl-1,3-thiazol-4-one chemical structure, C27H26N4O3S, CAS 380595-16-4](/s/DCDINLHUEBPIIO-JJIBRWJFSA-N.svg)
(5E)-5-[[3-(3-Methyl-4-prop-2-enoxyphenyl)-1-phenylpyrazol-4-yl]methylidene]-2-morpholin-4-yl-1,3-thiazol-4-one
CAS 380595-16-4C27H26N4O3S
![(5Z)-5-{[3-(4-Butoxy-3-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-(morpholin-4-yl)-1,3-thiazol-4(5H)-one chemical structure, C27H27ClN4O3S, CAS 1008881-59-1](/s/DOWVFGOETCWSPV-ULJHMMPZSA-N.svg)
(5Z)-5-{[3-(4-Butoxy-3-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-(morpholin-4-yl)-1,3-thiazol-4(5H)-one
CAS 1008881-59-1C27H27ClN4O3S
![(5E)-2-Morpholin-4-yl-5-[[1-phenyl-3-(4-propan-2-yloxyphenyl)pyrazol-4-yl]methylidene]-1,3-thiazol-4-one chemical structure, C26H26N4O3S, CAS 381685-33-2](/s/ZKMSSENWKAKVKA-XQNSMLJCSA-N.svg)
(5E)-2-Morpholin-4-yl-5-[[1-phenyl-3-(4-propan-2-yloxyphenyl)pyrazol-4-yl]methylidene]-1,3-thiazol-4-one
CAS 381685-33-2C26H26N4O3S
![5-{(Z)-1-[3-(3-Methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-morpholino-1,3-thiazol-4-one chemical structure, C24H22N4O3S, CAS 1009437-91-5](/s/AXKWWXNPPVDZTF-QNGOZBTKSA-N.svg)
5-{(Z)-1-[3-(3-Methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-morpholino-1,3-thiazol-4-one
CAS 1009437-91-5C24H22N4O3S
![5-{(Z)-1-[3-(3-Ethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-morpholino-1,3-thiazol-4-one chemical structure, C25H24N4O3S, CAS 1008884-44-3](/s/ZRFAFULLKAYIEL-JWGURIENSA-N.svg)
5-{(Z)-1-[3-(3-Ethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-morpholino-1,3-thiazol-4-one
CAS 1008884-44-3C25H24N4O3S
![2-Morpholino-5-{(Z)-1-[1-phenyl-3-(3-propoxyphenyl)-1H-pyrazol-4-yl]methylidene}-1,3-thiazol-4-one chemical structure, C26H26N4O3S, CAS 1008885-00-4](/s/PFLKGJPNYJEFMY-QJOMJCCJSA-N.svg)
2-Morpholino-5-{(Z)-1-[1-phenyl-3-(3-propoxyphenyl)-1H-pyrazol-4-yl]methylidene}-1,3-thiazol-4-one
CAS 1008885-00-4C26H26N4O3S
(Z)-5-((3-(4-(Allyloxy)-2-methylphenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)-2-morpholinothiazol-4(5H)-one
CAS 956201-95-9C27H26N4O3S
![(5Z)-2-(2,6-Dimethyl-4-morpholinyl)-5-{[3-(3-fluoro-4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-1,3-thiazol-4(5H)-one chemical structure, C26H25FN4O3S, CAS 624724-65-8](/s/SEYKVBKYECIZQZ-FMCGGJTJSA-N.svg)
(5Z)-2-(2,6-Dimethyl-4-morpholinyl)-5-{[3-(3-fluoro-4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-1,3-thiazol-4(5H)-one
CAS 624724-65-8C26H25FN4O3S
![(5Z)-5-({3-[4-(Butylsulfanyl)phenyl]-1-phenyl-1H-pyrazol-4-yl}methylidene)-2-(2,6-dimethylmorpholin-4-yl)-1,3-thiazol-4(5H)-one chemical structure, C29H32N4O2S2, CAS 955900-33-1](/s/UAKUXDBXZAFKIO-QQXSKIMKSA-N.svg)
(5Z)-5-({3-[4-(Butylsulfanyl)phenyl]-1-phenyl-1H-pyrazol-4-yl}methylidene)-2-(2,6-dimethylmorpholin-4-yl)-1,3-thiazol-4(5H)-one
CAS 955900-33-1C29H32N4O2S2
![2-(2,6-Dimethylmorpholino)-5-{(Z)-1-[3-(3-ethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-1,3-thiazol-4-one chemical structure, C27H28N4O3S, CAS 1009190-17-3](/s/ZOAZBAWXSKTUFY-OYKKKHCWSA-N.svg)
2-(2,6-Dimethylmorpholino)-5-{(Z)-1-[3-(3-ethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-1,3-thiazol-4-one
CAS 1009190-17-3C27H28N4O3S
![(5Z)-2-(2,6-Dimethylmorpholin-4-yl)-5-{[1-phenyl-3-(3-propoxyphenyl)-1H-pyrazol-4-yl]methylidene}-1,3-thiazol-4(5H)-one chemical structure, C28H30N4O3S, CAS 1009436-78-5](/s/USMZDASEEITNLV-MYYYXRDXSA-N.svg)
(5Z)-2-(2,6-Dimethylmorpholin-4-yl)-5-{[1-phenyl-3-(3-propoxyphenyl)-1H-pyrazol-4-yl]methylidene}-1,3-thiazol-4(5H)-one
CAS 1009436-78-5C28H30N4O3S
![(5Z)-5-{[3-(3-Chloro-4-propoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-(2,6-dimethylmorpholin-4-yl)-1,3-thiazol-4(5H)-one chemical structure, C28H29ClN4O3S, CAS 1009187-02-3](/s/PCQZQCJXNPZBAD-QFEZKATASA-N.svg)
(5Z)-5-{[3-(3-Chloro-4-propoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-(2,6-dimethylmorpholin-4-yl)-1,3-thiazol-4(5H)-one
CAS 1009187-02-3C28H29ClN4O3S
![5-{(Z)-1-[3-(3-Butoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-morpholino-1,3-thiazol-4-one chemical structure, C27H28N4O3S, CAS 1009189-92-7](/s/AYNHTGSKFOUNFT-MOHJPFBDSA-N.svg)
5-{(Z)-1-[3-(3-Butoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-morpholino-1,3-thiazol-4-one
CAS 1009189-92-7C27H28N4O3S
![5-{(Z)-1-[3-(3-Chloro-4-ethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-morpholino-1,3-thiazol-4-one chemical structure, C25H23ClN4O3S, CAS 1008881-27-3](/s/XIJUNEBEUKISNY-JCMHNJIXSA-N.svg)
5-{(Z)-1-[3-(3-Chloro-4-ethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-morpholino-1,3-thiazol-4-one
CAS 1008881-27-3C25H23ClN4O3S
![(5Z)-5-{[3-(3-Butoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-(2,6-dimethylmorpholin-4-yl)-1,3-thiazol-4(5H)-one chemical structure, C29H32N4O3S, CAS 1009438-82-7](/s/HXIUMCUWPDZGOG-QQXSKIMKSA-N.svg)
(5Z)-5-{[3-(3-Butoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-(2,6-dimethylmorpholin-4-yl)-1,3-thiazol-4(5H)-one
CAS 1009438-82-7C29H32N4O3S
![(5Z)-5-{[3-(3-Chloro-4-ethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-(2,6-dimethylmorpholin-4-yl)-1,3-thiazol-4(5H)-one chemical structure, C27H27ClN4O3S, CAS 1009436-13-8](/s/LGCRZBKDXOYAFN-CFRMEGHHSA-N.svg)
(5Z)-5-{[3-(3-Chloro-4-ethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-(2,6-dimethylmorpholin-4-yl)-1,3-thiazol-4(5H)-one
CAS 1009436-13-8C27H27ClN4O3S
![N,N-Dimethyl-3-(4-{(Z)-[2-(morpholin-4-yl)-4-oxo-1,3-thiazol-5(4H)-ylidene]methyl}-1-phenyl-1H-pyrazol-3-yl)benzenesulfonamide chemical structure, C25H25N5O4S2, CAS 958951-17-2](/s/WDVXATXUCPBGMK-JWGURIENSA-N.svg)
N,N-Dimethyl-3-(4-{(Z)-[2-(morpholin-4-yl)-4-oxo-1,3-thiazol-5(4H)-ylidene]methyl}-1-phenyl-1H-pyrazol-3-yl)benzenesulfonamide
CAS 958951-17-2C25H25N5O4S2
![(5Z)-2-(2,6-Dimethylmorpholin-4-yl)-5-({1-phenyl-3-[4-(propylsulfanyl)phenyl]-1H-pyrazol-4-yl}methylidene)-1,3-thiazol-4(5H)-one chemical structure, C28H30N4O2S2, CAS 955867-01-3](/s/WDLZXWNVRIDMOO-MYYYXRDXSA-N.svg)
(5Z)-2-(2,6-Dimethylmorpholin-4-yl)-5-({1-phenyl-3-[4-(propylsulfanyl)phenyl]-1H-pyrazol-4-yl}methylidene)-1,3-thiazol-4(5H)-one
CAS 955867-01-3C28H30N4O2S2
Related scaffolds
Same ring framework with different atoms or bond orders
